SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lr4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS6_A_DXCA75_0
(PPCA)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 8 ILE A 164
LEU A 219
PHE A 197
GLY A 192
 None
 1.07A 1os6A-4lr4A:
undetectable		 1os6A-4lr4A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 PHE A  93
TYR A 244
TYR A 130
 None
None
GOL  A 402 ( 4.5A)
 0.96A 1x70B-4lr4A:
undetectable		 1x70B-4lr4A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 VAL A 387
GLU A  55
GLU A 293
 None
 0.78A 2nv4A-4lr4A:
undetectable		 2nv4A-4lr4A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 7 LEU A 219
PHE A 197
ILE A 176
PHE A 166
 None
 0.96A 2opxA-4lr4A:
undetectable		 2opxA-4lr4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 6 VAL A 365
TRP A 338
TRP A 339
THR A 376
 None
 1.15A 2x2iA-4lr4A:
undetectable		 2x2iA-4lr4A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 TYR A 385
VAL A  57
THR A 254
 None
 0.61A 2ygnA-4lr4A:
2.1		 2ygnA-4lr4A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_1
(ENDOTHIAPEPSIN)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		5 / 12 ILE A 207
GLY A 119
LEU A 249
TYR A 152
ILE A 226
 None
 1.02A 3pwwA-4lr4A:
undetectable		 3pwwA-4lr4A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A 164
LEU A 219
PHE A 197
GLY A 192
 None
 1.04A 4hc3A-4lr4A:
undetectable		 4hc3A-4lr4A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 GLU A 159
TYR A  82
GLU A 293
 None
 0.84A 4ryaA-4lr4A:
undetectable		 4ryaA-4lr4A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 5 PHE A 228
ILE A 164
GLY A 242
ILE A 226
 None
 0.86A 5dzkB-4lr4A:
undetectable
5dzkI-4lr4A:
undetectable
5dzkW-4lr4A:
undetectable		 5dzkB-4lr4A:
20.28
5dzkI-4lr4A:
19.58
5dzkW-4lr4A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		5 / 12 GLY A 336
THR A 377
VAL A 343
ALA A 333
LEU A 342
 None
 0.99A 5kocA-4lr4A:
undetectable		 5kocA-4lr4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 7 TYR A 185
ILE A 176
ILE A 184
ILE A 220
 None
 0.94A 5murB-4lr4A:
undetectable		 5murB-4lr4A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 LYS A 267
TRP A 268
SER A 374
 None
 1.29A 5nwwA-4lr4A:
undetectable		 5nwwA-4lr4A:
5.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 HIS A 240
GLU A 169
TRP A  98
 None
PO4  A 405 (-2.8A)
None
 1.15A 5odqD-4lr4A:
undetectable		 5odqD-4lr4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODR_D_ACTD202_0
(METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
D)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		3 / 3 HIS A 240
GLU A 169
TRP A  98
 None
PO4  A 405 (-2.8A)
None
 1.12A 5odrD-4lr4A:
undetectable		 5odrD-4lr4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B202_1
(ENDO-1,4-BETA-XYLANA
SE A)		 4lr4 HYPOTHETICAL PROTEIN
([Eubacterium]
rectale) 		4 / 8 TRP A  98
THR A  99
TYR A 138
ARG A 135
 None
None
GOL  A 404 (-4.2A)
None
 1.10A 5tzoB-4lr4A:
undetectable		 5tzoB-4lr4A:
25.00