SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lri'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HUO_A_PNNA302_0 (CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	4 / 6	LEU P 206 GLY P 207 ALA P 142 PRO P 143	None	0.46A	3huoA-4lriP: undetectable	3huoA-4lriP: 24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JX1_B_CAMB502_0 (CAMPHOR 5-MONOOXYGENASE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	5 / 10	PHE P 139 GLY P 135 THR P 222 VAL P 215 VAL P 224	None	1.18A	4jx1B-4lriP: undetectable	4jx1B-4lriP: 18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_A_1GNA607_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.75A	5jsdA-4lriP: undetectable	5jsdA-4lriP: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_B_1GNB618_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.75A	5jsdB-4lriP: undetectable	5jsdB-4lriP: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSD_C_1GNC608_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.75A	5jsdC-4lriP: undetectable	5jsdC-4lriP: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_A_1GNA608_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.75A	5jseA-4lriP: undetectable	5jseA-4lriP: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_B_1GNB611_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.77A	5jseB-4lriP: 2.9	5jseB-4lriP: 15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JSE_C_1GNC611_1 (PHIAB6 TAILSPIKE)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	3 / 3	THR P 28 SER P 30 TYR P 32	None	0.77A	5jseC-4lriP: 2.9	5jseC-4lriP: 15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	4lri	MSL-109 HEAVY CHAIN (Homo sapiens)	4 / 5	SER P 129 ALA P 131 PHE P 163 LEU P 187	None	0.32A	5mthA-4lriP: 25.7	5mthA-4lriP: 53.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3HUO_A_PNNA302_0","CTX-M-9 EXTENDED-SPECTRUM BETA-LACTAMASE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",4,"LEU P 206;GLY P 207;ALA P 142;PRO P 143","None","0.46A","3huoA-4lriP:undetectable","3huoA-4lriP:24.22"],["4JX1_B_CAMB502_0","CAMPHOR 5-MONOOXYGENASE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",5,"PHE P 139;GLY P 135;THR P 222;VAL P 215;VAL P 224","None","1.18A","4jx1B-4lriP:undetectable","4jx1B-4lriP:18.16"],["5JSD_A_1GNA607_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.75A","5jsdA-4lriP:undetectable","5jsdA-4lriP:15.86"],["5JSD_B_1GNB618_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.75A","5jsdB-4lriP:undetectable","5jsdB-4lriP:15.86"],["5JSD_C_1GNC608_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.75A","5jsdC-4lriP:undetectable","5jsdC-4lriP:15.86"],["5JSE_A_1GNA608_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.75A","5jseA-4lriP:undetectable","5jseA-4lriP:15.86"],["5JSE_B_1GNB611_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.77A","5jseB-4lriP:2.9","5jseB-4lriP:15.86"],["5JSE_C_1GNC611_1","PHIAB6 TAILSPIKE","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",3,"THR P  28;SER P  30;TYR P  32","None","0.77A","5jseC-4lriP:2.9","5jseC-4lriP:15.86"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","4lri","MSL-109 HEAVY CHAIN","Homo sapiens",4,"SER P 129;ALA P 131;PHE P 163;LEU P 187","None","0.32A","5mthA-4lriP:25.7","5mthA-4lriP:53.45"]]