SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lrj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N8X_B_NIMB1701_2 (PROSTAGLANDIN G/H SYNTHASE 1)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	3 / 3	VAL A 288 VAL A 245 SER A 208	None	0.72A	3n8xB-4lrjA: undetectable	3n8xB-4lrjA: 14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WAR_A_NIOA401_1 (CASEIN KINASE II SUBUNIT ALPHA)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	4 / 8	VAL A 147 VAL A 157 LYS A 159 ILE A 257	ANP A 301 (-4.2A) ANP A 301 (-4.9A) ANP A 301 (-3.6A) ANP A 301 (-4.2A)	0.58A	3warA-4lrjA: 9.8	3warA-4lrjA: 19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AN2_A_EUIA1382_1 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	6 / 12	LYS A 159 ILE A 199 MET A 201 ASP A 239 ASN A 244 ASP A 258	ANP A 301 (-3.6A) None ANP A 301 (-3.5A) None MG A 302 ( 4.4A) MG A 302 ( 2.9A)	0.92A	4an2A-4lrjA: 8.4	4an2A-4lrjA: 21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DT8_A_ADNA401_1 (APH(2'')-ID)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	5 / 11	GLY A 140 LYS A 159 ILE A 204 LEU A 246 ILE A 257	ANP A 301 ( 3.9A) ANP A 301 (-3.6A) ANP A 301 (-4.3A) None ANP A 301 (-4.2A)	0.86A	4dt8A-4lrjA: 7.6	4dt8A-4lrjA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DT8_B_ADNB401_1 (APH(2'')-ID)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	5 / 10	GLY A 140 LYS A 159 ILE A 204 LEU A 246 ILE A 257	ANP A 301 ( 3.9A) ANP A 301 (-3.6A) ANP A 301 (-4.3A) None ANP A 301 (-4.2A)	0.87A	4dt8B-4lrjA: 7.8	4dt8B-4lrjA: 20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BW4_B_SAMB301_1 (16S RRNA (ADENINE(1408)-N(1)) -METHYLTRANSFERASE)	4lrj	EFFECTOR NLEH1 (Escherichia coli)	3 / 3	ASP A 239 GLU A 169 SER A 208	None	0.76A	5bw4B-4lrjA: undetectable	5bw4B-4lrjA: 20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Y9M_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4lrj	EFFECTOR NLEH1 (Escherichia coli)	4 / 8	VAL A 147 VAL A 157 LYS A 159 ILE A 257	ANP A 301 (-4.2A) ANP A 301 (-4.9A) ANP A 301 (-3.6A) ANP A 301 (-4.2A)	0.39A	5y9mX-4lrjA: 9.2	5y9mX-4lrjA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_B_NIOB401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4lrj	EFFECTOR NLEH1 (Escherichia coli)	4 / 7	VAL A 147 VAL A 157 LYS A 159 ILE A 257	ANP A 301 (-4.2A) ANP A 301 (-4.9A) ANP A 301 (-3.6A) ANP A 301 (-4.2A)	0.59A	5yf9B-4lrjA: 9.1	5yf9B-4lrjA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YF9_X_NIOX401_1 (CASEIN KINASE II SUBUNIT ALPHA')	4lrj	EFFECTOR NLEH1 (Escherichia coli)	5 / 9	VAL A 147 VAL A 157 LYS A 159 ILE A 257 ASP A 258	ANP A 301 (-4.2A) ANP A 301 (-4.9A) ANP A 301 (-3.6A) ANP A 301 (-4.2A) MG A 302 ( 2.9A)	1.08A	5yf9X-4lrjA: 9.4	5yf9X-4lrjA: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YWM_X_NIOX403_0 (CASEIN KINASE II SUBUNIT ALPHA')	4lrj	EFFECTOR NLEH1 (Escherichia coli)	4 / 7	VAL A 147 VAL A 157 LYS A 159 ILE A 257	ANP A 301 (-4.2A) ANP A 301 (-4.9A) ANP A 301 (-3.6A) ANP A 301 (-4.2A)	0.43A	5ywmX-4lrjA: 8.6	5ywmX-4lrjA: 18.45

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3N8X_B_NIMB1701_2","PROSTAGLANDIN G\/H SYNTHASE 1","4lrj","EFFECTOR NLEH1","Escherichia coli",3,"VAL A 288;VAL A 245;SER A 208","None","0.72A","3n8xB-4lrjA:undetectable","3n8xB-4lrjA:14.65"],["3WAR_A_NIOA401_1","CASEIN KINASE II SUBUNIT ALPHA","4lrj","EFFECTOR NLEH1","Escherichia coli",4,"VAL A 147;VAL A 157;LYS A 159;ILE A 257","ANP A 301 (-4.2A);ANP A 301 (-4.9A);ANP A 301 (-3.6A);ANP A 301 (-4.2A)","0.58A","3warA-4lrjA:9.8","3warA-4lrjA:19.88"],["4AN2_A_EUIA1382_1","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","4lrj","EFFECTOR NLEH1","Escherichia coli",6,"LYS A 159;ILE A 199;MET A 201;ASP A 239;ASN A 244;ASP A 258","ANP A 301 (-3.6A);None;ANP A 301 (-3.5A);None; MG A 302 ( 4.4A); MG A 302 ( 2.9A)","0.92A","4an2A-4lrjA:8.4","4an2A-4lrjA:21.48"],["4DT8_A_ADNA401_1","APH(2'')-ID","4lrj","EFFECTOR NLEH1","Escherichia coli",5,"GLY A 140;LYS A 159;ILE A 204;LEU A 246;ILE A 257","ANP A 301 ( 3.9A);ANP A 301 (-3.6A);ANP A 301 (-4.3A);None;ANP A 301 (-4.2A)","0.86A","4dt8A-4lrjA:7.6","4dt8A-4lrjA:20.59"],["4DT8_B_ADNB401_1","APH(2'')-ID","4lrj","EFFECTOR NLEH1","Escherichia coli",5,"GLY A 140;LYS A 159;ILE A 204;LEU A 246;ILE A 257","ANP A 301 ( 3.9A);ANP A 301 (-3.6A);ANP A 301 (-4.3A);None;ANP A 301 (-4.2A)","0.87A","4dt8B-4lrjA:7.8","4dt8B-4lrjA:20.59"],["5BW4_B_SAMB301_1","16S RRNA (ADENINE(1408)-N(1))-METHYLTRANSFERASE","4lrj","EFFECTOR NLEH1","Escherichia coli",3,"ASP A 239;GLU A 169;SER A 208","None","0.76A","5bw4B-4lrjA:undetectable","5bw4B-4lrjA:20.68"],["5Y9M_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","4lrj","EFFECTOR NLEH1","Escherichia coli",4,"VAL A 147;VAL A 157;LYS A 159;ILE A 257","ANP A 301 (-4.2A);ANP A 301 (-4.9A);ANP A 301 (-3.6A);ANP A 301 (-4.2A)","0.39A","5y9mX-4lrjA:9.2","5y9mX-4lrjA:18.45"],["5YF9_B_NIOB401_1","CASEIN KINASE II SUBUNIT ALPHA'","4lrj","EFFECTOR NLEH1","Escherichia coli",4,"VAL A 147;VAL A 157;LYS A 159;ILE A 257","ANP A 301 (-4.2A);ANP A 301 (-4.9A);ANP A 301 (-3.6A);ANP A 301 (-4.2A)","0.59A","5yf9B-4lrjA:9.1","5yf9B-4lrjA:18.45"],["5YF9_X_NIOX401_1","CASEIN KINASE II SUBUNIT ALPHA'","4lrj","EFFECTOR NLEH1","Escherichia coli",5,"VAL A 147;VAL A 157;LYS A 159;ILE A 257;ASP A 258","ANP A 301 (-4.2A);ANP A 301 (-4.9A);ANP A 301 (-3.6A);ANP A 301 (-4.2A); MG A 302 ( 2.9A)","1.08A","5yf9X-4lrjA:9.4","5yf9X-4lrjA:18.45"],["5YWM_X_NIOX403_0","CASEIN KINASE II SUBUNIT ALPHA'","4lrj","EFFECTOR NLEH1","Escherichia coli",4,"VAL A 147;VAL A 157;LYS A 159;ILE A 257","ANP A 301 (-4.2A);ANP A 301 (-4.9A);ANP A 301 (-3.6A);ANP A 301 (-4.2A)","0.43A","5ywmX-4lrjA:8.6","5ywmX-4lrjA:18.45"]]