SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_A_MTXA732_1
(THYMIDYLATE SYNTHASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 LEU A   6
GLY A 105
PHE A  25
VAL A 135
ALA A 134
 None
 1.09A 1axwA-4lruA:
undetectable		 1axwA-4lruA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLS_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 LEU A   6
GLY A 105
PHE A  25
VAL A 135
ALA A 134
 None
 0.98A 1tlsA-4lruA:
undetectable		 1tlsA-4lruA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 LEU A   6
GLY A 105
PHE A  25
VAL A 135
ALA A 134
 None
 1.04A 1tsnA-4lruA:
undetectable		 1tsnA-4lruA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 THR A  22
THR A 174
GLY A 105
HIS A 137
PHE A 110
 None
 1.42A 1v8bA-4lruA:
undetectable		 1v8bA-4lruA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 THR A  22
THR A 174
GLY A 105
HIS A 137
PHE A 110
 None
 1.46A 1v8bD-4lruA:
4.1		 1v8bD-4lruA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VM1_A_TAZA504_1
(BETA-LACTAMASE SHV-1)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		3 / 3 ASP A  98
TYR A  97
GLU A  42
 None
 0.77A 1vm1A-4lruA:
undetectable		 1vm1A-4lruA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 LEU A  86
ASN A  85
LEU A  83
ALA A  82
LEU A   5
 None
 1.03A 1ya3C-4lruA:
undetectable		 1ya3C-4lruA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 8 SER A  17
PHE A  15
LEU A 109
ASP A 169
 None
 1.00A 2bxkA-4lruA:
undetectable		 2bxkA-4lruA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_A_TPFA490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 8 PHE A  36
TYR A  41
ALA A 226
THR A 209
 None
 0.95A 3l4dA-4lruA:
undetectable		 3l4dA-4lruA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 8 ASP A 127
ASP A 147
PRO A 153
GLN A 119
 None
 1.00A 3oyaA-4lruA:
undetectable		 3oyaA-4lruA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 ALA A 122
ILE A 141
THR A 215
ILE A 213
THR A 123
 None
 1.18A 3qfxA-4lruA:
undetectable		 3qfxA-4lruA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 ALA A 122
ILE A 141
THR A 215
ILE A 213
THR A 123
 None
 1.18A 3qfxB-4lruA:
undetectable		 3qfxB-4lruA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 6 TYR A 196
GLY A 162
VAL A 208
THR A 215
 None
 0.87A 3tj7A-4lruA:
undetectable
3tj7B-4lruA:
undetectable		 3tj7A-4lruA:
20.08
3tj7B-4lruA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 6 TYR A 196
GLY A 162
VAL A 208
THR A 215
 None
 0.85A 3tj7C-4lruA:
undetectable
3tj7D-4lruA:
undetectable		 3tj7C-4lruA:
20.08
3tj7D-4lruA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 6 VAL A 208
THR A 215
TYR A 196
GLY A 162
 None
 0.88A 3tj7C-4lruA:
undetectable
3tj7D-4lruA:
undetectable		 3tj7C-4lruA:
20.08
3tj7D-4lruA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 LEU A  86
ASN A  85
LEU A  83
ALA A  82
LEU A   5
 None
 0.90A 4ltwA-4lruA:
undetectable		 4ltwA-4lruA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 GLU A  48
ALA A   7
ALA A 140
GLY A 107
LEU A 109
 None
 1.03A 4oaeA-4lruA:
undetectable		 4oaeA-4lruA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 12 ASP A 204
ASN A 218
GLY A 201
PHE A 206
GLY A 216
 None
 0.97A 4pevB-4lruA:
3.4		 4pevB-4lruA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		3 / 3 GLN A 187
THR A 184
ASP A 165
 None
 0.78A 5k9dA-4lruA:
undetectable		 5k9dA-4lruA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 8 GLU A  28
VAL A  27
GLY A  23
THR A   9
 None
 0.96A 5sxqA-4lruA:
undetectable		 5sxqA-4lruA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 7 PHE A 101
VAL A 229
ILE A 160
THR A 225
 None
 0.97A 5vkqA-4lruA:
undetectable
5vkqD-4lruA:
undetectable		 5vkqA-4lruA:
8.30
5vkqD-4lruA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 7 THR A 225
PHE A 101
VAL A 229
ILE A 160
 None
 0.95A 5vkqA-4lruA:
undetectable
5vkqB-4lruA:
undetectable		 5vkqA-4lruA:
8.30
5vkqB-4lruA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 8 THR A 225
PHE A 101
VAL A 229
ILE A 160
 None
 0.94A 5vkqB-4lruA:
undetectable
5vkqC-4lruA:
undetectable		 5vkqB-4lruA:
8.30
5vkqC-4lruA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		4 / 7 THR A 225
PHE A 101
VAL A 229
ILE A 160
 None
 0.93A 5vkqC-4lruA:
undetectable
5vkqD-4lruA:
undetectable		 5vkqC-4lruA:
8.30
5vkqD-4lruA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4lru GLYOXALASE III
(GLUTATHIONE-INDEPEN
DENT)
(Candida
albicans) 		5 / 11 ILE A  43
LEU A   8
GLY A 102
SER A 133
ALA A 226
 None
 1.25A 6ieyA-4lruA:
2.6
6ieyB-4lruA:
3.2		 6ieyA-4lruA:
22.39
6ieyB-4lruA:
22.39