SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXW_B_RITB301_1
(HIV-1 PROTEASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 9 GLY A 219
GLY A 327
ILE A 189
VAL A 150
ILE A 217
 None
 1.05A 1hxwA-4lryA:
undetectable		 1hxwA-4lryA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 7 PHE A 204
PHE A  78
HIS A 218
VAL A 215
 None
None
GOL  A 401 (-3.2A)
None
 1.01A 1lh6A-4lryA:
undetectable		 1lh6A-4lryA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PK7_C_ADNC1247_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 10 ARG A 225
GLY A 219
VAL A 215
GLU A 212
SER A 203
 None
 1.43A 1pk7C-4lryA:
3.0		 1pk7C-4lryA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA C 232
LEU C 252
PHE C 275
LEU C 258
ILE C 286
 None
 1.14A 1re7B-4lryC:
undetectable		 1re7B-4lryC:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 LEU A 323
HIS A 218
ILE A 217
 None
GOL  A 401 (-3.2A)
None
 0.62A 1s9pB-4lryA:
undetectable		 1s9pB-4lryA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		6 / 12 LEU A  48
GLY A  67
SER A  50
ILE A 102
VAL A 154
GLY A 161
 None
 1.16A 1uakA-4lryA:
undetectable		 1uakA-4lryA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 ILE A 316
ARG A 313
LEU A 315
ASN A 314
 None
 1.20A 1y0xX-4lryA:
undetectable		 1y0xX-4lryA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 PHE A 204
PHE A  78
HIS A 218
VAL A 215
 None
None
GOL  A 401 (-3.2A)
None
 1.01A 2lh6A-4lryA:
undetectable		 2lh6A-4lryA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_C_MTXC613_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA C 273
LEU C 258
LEU C 301
THR C 253
LEU C 238
 None
 1.18A 2oipC-4lryC:
undetectable		 2oipC-4lryC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 LEU C 268
LEU C 301
LEU C 303
ALA C 284
PHE C 275
 None
 1.30A 2vcvE-4lryC:
undetectable		 2vcvE-4lryC:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 9 VAL A 130
ILE A 102
LEU A 342
GLY A 161
ALA A 163
 None
 1.45A 2xf3B-4lryA:
undetectable		 2xf3B-4lryA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B500_1
(ORF12)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 9 VAL A 130
ILE A 102
LEU A 342
GLY A 161
ALA A 163
 None
 1.45A 2xfsB-4lryA:
undetectable		 2xfsB-4lryA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 9 VAL A 130
ILE A 102
LEU A 342
GLY A 161
ALA A 163
 None
 1.45A 2xh9B-4lryA:
undetectable		 2xh9B-4lryA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.33A 2zj0A-4lryA:
2.9		 2zj0A-4lryA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 12 ILE A 217
SER A 141
GLY A 214
GLY A 222
ASN A 283
 None
 1.19A 2zw9A-4lryA:
undetectable		 2zw9A-4lryA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 LYS A 269
ILE A 110
PHE A 113
 None
 0.95A 3j7zS-4lryA:
1.7
3j7za-4lryA:
undetectable		 3j7zS-4lryA:
15.98
3j7za-4lryA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 ASN C 229
ALA C 233
LEU C 238
ALA C 240
SER C 243
 None
 1.25A 3kp6B-4lryC:
2.2		 3kp6B-4lryC:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 12 LEU C  54
CYH C  83
THR C  81
LEU A 119
HIS C  36
 None
 1.30A 3sp9B-4lryC:
undetectable		 3sp9B-4lryC:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 ASP A 109
GLY A  53
TYR A 106
 GOL  A 401 (-2.9A)
GOL  A 401 (-3.0A)
GOL  A 401 ( 4.3A)
 0.80A 3w9tC-4lryA:
undetectable		 3w9tC-4lryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 ASP A 109
GLY A  53
TYR A 106
 GOL  A 401 (-2.9A)
GOL  A 401 (-3.0A)
GOL  A 401 ( 4.3A)
 0.79A 3w9tG-4lryA:
undetectable		 3w9tG-4lryA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQE_B_DXCB1079_0
(PROTEIN PRGI, CELL
INVASION PROTEIN
SIPD)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 11 PRO A 350
GLN A  92
THR A  27
LEU A  26
TYR A  34
 None
 1.26A 3zqeA-4lryA:
undetectable
3zqeB-4lryA:
undetectable		 3zqeA-4lryA:
21.52
3zqeB-4lryA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 GLN A 183
ASP A 276
GLN A 273
 None
 0.93A 4aztA-4lryA:
undetectable		 4aztA-4lryA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 11 ARG A 225
GLY A 219
VAL A 215
GLU A 212
SER A 203
 None
 1.29A 4d9hA-4lryA:
2.8		 4d9hA-4lryA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DA7_A_AC2A301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 10 ARG A 225
GLY A 219
VAL A 215
GLU A 212
SER A 203
 None
 1.24A 4da7A-4lryA:
2.8		 4da7A-4lryA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_A_2FAA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 11 ARG A 225
GLY A 219
VAL A 215
GLU A 212
SER A 203
 None
 1.20A 4danA-4lryA:
undetectable		 4danA-4lryA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 12 ARG A 225
GLY A 219
VAL A 215
GLU A 212
SER A 203
 None
 1.16A 4danA-4lryA:
undetectable
4danB-4lryA:
3.1		 4danA-4lryA:
22.56
4danB-4lryA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 6 ALA C  52
GLY C 186
LEU C  56
VAL C 185
 None
 0.98A 4dubA-4lryC:
undetectable		 4dubA-4lryC:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 6 THR A 288
GLY A 286
ASN A 284
GLY A 188
 None
 0.82A 4fjpA-4lryA:
undetectable		 4fjpA-4lryA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ILE C  16
LYS C 129
THR C 170
VAL C 167
ASP C 133
 None
 1.01A 4i41A-4lryC:
undetectable		 4i41A-4lryC:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 THR C 130
ALA C 117
LEU C  78
THR C 178
LEU C 175
 None
 1.44A 4ltwA-4lryC:
undetectable		 4ltwA-4lryC:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.23A 4lvcA-4lryA:
2.9		 4lvcA-4lryA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.23A 4lvcC-4lryA:
3.4		 4lvcC-4lryA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 CYH A 304
LEU A 272
LEU A 333
LEU A 242
 None
 1.10A 4n09D-4lryA:
2.8		 4n09D-4lryA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA C 232
LEU C 252
PHE C 275
LEU C 258
ILE C 286
 None
 1.10A 4nx7A-4lryC:
undetectable		 4nx7A-4lryC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_B_ADNB501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 12 VAL A 282
GLY A 295
PHE A 228
PHE A 328
GLY A 327
 None
 1.21A 4pevB-4lryA:
2.8		 4pevB-4lryA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 12 ALA C 232
LEU C 252
PHE C 275
LEU C 258
ILE C 286
 None
 1.07A 4pstA-4lryC:
undetectable		 4pstA-4lryC:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 ALA C 284
PHE C 275
ASN C 229
ILE C 228
GLY C 215
 None
 1.01A 4r20B-4lryC:
undetectable		 4r20B-4lryC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 11 ALA A 351
LEU A 352
GLU A 157
ASN A 283
LEU A 281
 None
 0.95A 4wg0C-4lryA:
undetectable
4wg0D-4lryA:
undetectable
4wg0E-4lryA:
undetectable		 4wg0C-4lryA:
7.80
4wg0D-4lryA:
7.80
4wg0E-4lryA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 11 ALA A 351
LEU A 352
GLU A 157
ASN A 283
LEU A 281
 None
 0.97A 4wg0E-4lryA:
undetectable
4wg0F-4lryA:
undetectable
4wg0G-4lryA:
undetectable		 4wg0E-4lryA:
7.80
4wg0F-4lryA:
7.80
4wg0G-4lryA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z69_A_DIFA1008_1
(SERUM ALBUMIN)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 9 SER C 119
ALA C 147
PHE C 145
SER C 124
LEU C 120
 None
 1.33A 4z69A-4lryC:
undetectable		 4z69A-4lryC:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 4 VAL A 215
ILE A 187
ASN A 283
VAL A 150
 None
 1.22A 5ajqA-4lryA:
undetectable		 5ajqA-4lryA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		4 / 8 PHE C 102
ILE C  84
PRO C 149
THR C 160
 None
 1.06A 5x23A-4lryC:
undetectable		 5x23A-4lryC:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YK2_A_ERYA501_0
(PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE OPERON
REGULATORY PROTEIN
(Escherichia
coli) 		5 / 11 GLU C  66
GLY C  57
ALA C  59
ILE C 181
VAL C 185
 None
 1.12A 5yk2A-4lryC:
undetectable		 5yk2A-4lryC:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		3 / 3 LYS A 179
LEU A 342
ASP A 336
 None
 0.89A 5zv2A-4lryA:
undetectable		 5zv2A-4lryA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		6 / 12 LEU A  79
GLY A  52
GLY A  75
ILE A  86
SER A  50
ILE A 103
 None
GOL  A 401 (-2.9A)
None
None
None
None
 1.23A 6ectA-4lryA:
undetectable		 6ectA-4lryA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.27A 6gbnA-4lryA:
2.9		 6gbnA-4lryA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		4 / 5 THR A 129
THR A 153
HIS A  60
LEU A  69
 None
 1.26A 6gbnD-4lryA:
undetectable		 6gbnD-4lryA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NQA_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 4lry PTS-DEPENDENT
DIHYDROXYACETONE
KINASE,
DIHYDROXYACETONE-BIN
DING SUBUNIT DHAK
(Escherichia
coli) 		5 / 10 ASP A  94
GLY A  95
GLY A  98
VAL A 125
GLU A  97
 None
 1.42A 6nqaK-4lryA:
undetectable		 6nqaK-4lryA:
21.18