SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ls3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 208
LEU A 170
MET A 173
THR A 157
PHE A 143
 None
 1.34A 1a28A-4ls3A:
undetectable		 1a28A-4ls3A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 6 ALA A  65
TYR A  56
ILE A 155
PRO A 287
 None
 1.27A 1oniB-4ls3A:
undetectable
1oniC-4ls3A:
undetectable		 1oniB-4ls3A:
19.69
1oniC-4ls3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 119
ILE A  54
ALA A 161
ILE A 155
 None
 0.63A 1oniB-4ls3A:
undetectable
1oniC-4ls3A:
undetectable		 1oniB-4ls3A:
19.69
1oniC-4ls3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_H_BEZH515_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 6 ALA A  65
TYR A  56
ILE A 155
PRO A 287
 None
 1.19A 1oniH-4ls3A:
undetectable
1oniI-4ls3A:
undetectable		 1oniH-4ls3A:
19.69
1oniI-4ls3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 162
ILE A 155
SER A  83
SER A  59
ILE A  54
 None
None
None
HIS  A 601 ( 4.8A)
None
 1.21A 1xotA-4ls3A:
undetectable		 1xotA-4ls3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		3 / 3 SER A  59
GLU A 150
ASP A 211
 HIS  A 601 ( 4.8A)
None
None
 0.81A 2avdB-4ls3A:
undetectable		 2avdB-4ls3A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 5 SER A  59
GLY A 285
ASP A 165
ASP A 154
 HIS  A 601 ( 4.8A)
None
None
None
 1.02A 2oxtB-4ls3A:
undetectable		 2oxtB-4ls3A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		3 / 3 VAL A 226
LYS A 227
HIS A 103
 None
None
NI  A 603 (-3.3A)
 0.89A 3elzA-4ls3A:
undetectable		 3elzA-4ls3A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 7 LEU A 324
TYR A 318
MET A  66
ARG A 183
 None
 1.30A 3ik3B-4ls3A:
undetectable		 3ik3B-4ls3A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 119
GLY A  43
GLN A  45
PHE A  42
SER A 142
 None
 1.32A 3tbgA-4ls3A:
undetectable		 3tbgA-4ls3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 LEU A 119
GLY A  43
GLN A  45
PHE A  42
SER A 142
 None
 1.32A 3tbgC-4ls3A:
undetectable		 3tbgC-4ls3A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		6 / 12 LEU A 279
ILE A 292
LEU A 208
GLY A 285
ILE A 148
ALA A 149
 None
 1.39A 3uwlB-4ls3A:
undetectable		 3uwlB-4ls3A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_2
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		3 / 3 LYS A 172
THR A 176
ILE A 310
 None
 0.79A 4e0fB-4ls3A:
undetectable		 4e0fB-4ls3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		4 / 8 GLU A 241
GLU A 194
GLY A 204
SER A 203
 None
 0.95A 4f93B-4ls3A:
undetectable		 4f93B-4ls3A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN
(Helicobacter
pylori) 		5 / 12 GLU A 150
VAL A 151
ASP A 154
ASP A 209
ALA A 289
 None
 1.22A 5syeB-4ls3A:
undetectable		 5syeB-4ls3A:
20.40