SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ls5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 188
THR A 165
ALA A  77
ALA A 142
ILE A 146
 None
 0.82A 1bx4A-4ls5A:
undetectable		 1bx4A-4ls5A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.97A 1dhiA-4ls5A:
undetectable		 1dhiA-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 11 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.98A 1dhiB-4ls5A:
undetectable		 1dhiB-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.96A 1dhjA-4ls5A:
undetectable		 1dhjA-4ls5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.99A 1dhjB-4ls5A:
undetectable		 1dhjB-4ls5A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.00A 1draB-4ls5A:
undetectable		 1draB-4ls5A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.98A 1drbA-4ls5A:
undetectable		 1drbA-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.99A 1drbB-4ls5A:
undetectable		 1drbB-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 THR A 195
SER A 198
PHE A 202
VAL A 160
ALA A 162
 None
 1.27A 1q23D-4ls5A:
undetectable
1q23E-4ls5A:
undetectable		 1q23D-4ls5A:
17.29
1q23E-4ls5A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.99A 1ra3A-4ls5A:
undetectable		 1ra3A-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 10 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.99A 1rb3A-4ls5A:
undetectable		 1rb3A-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.97A 1rb3B-4ls5A:
undetectable		 1rb3B-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 11 ALA A 234
GLY A 345
GLY A 166
VAL A 186
ILE A 236
 None
 0.88A 1sduA-4ls5A:
undetectable		 1sduA-4ls5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 11 GLY A 346
ALA A 349
VAL A   7
ILE A 256
GLY A 171
ILE A 237
 None
 1.41A 1sdvB-4ls5A:
undetectable		 1sdvB-4ls5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 GLY A 346
ALA A 349
VAL A   7
ILE A 256
GLY A 171
ILE A 237
 None
 1.38A 2avvB-4ls5A:
undetectable		 2avvB-4ls5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.99A 2drcB-4ls5A:
undetectable		 2drcB-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 VAL A 379
ASN A 300
ALA A 355
GLN A 386
 None
K  A 501 (-3.8A)
None
None
 0.94A 2ij7C-4ls5A:
undetectable		 2ij7C-4ls5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 VAL A 379
VAL A 330
ALA A 355
GLN A 386
 None
 0.98A 2ij7C-4ls5A:
undetectable		 2ij7C-4ls5A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 GLY A 342
GLY A 107
GLY A 109
THR A 165
HIS A 401
HIS A 302
 None
 1.34A 2oxtD-4ls5A:
undetectable		 2oxtD-4ls5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKM_A_ADNA501_1
(ADENOSINE KINASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ALA A 349
GLY A 346
GLY A 345
ALA A 403
GLY A 105
 None
 0.89A 2pkmA-4ls5A:
undetectable		 2pkmA-4ls5A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 9 LEU A 340
ILE A 347
GLY A 346
GLY A 188
LEU A  13
 None
 0.98A 2qmmA-4ls5A:
undetectable		 2qmmA-4ls5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 11 LEU A 340
ILE A 347
GLY A 346
GLY A 188
LEU A  13
 None
 0.95A 2qmmA-4ls5A:
undetectable
2qmmB-4ls5A:
undetectable		 2qmmA-4ls5A:
19.71
2qmmB-4ls5A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 GLY A 346
ALA A 349
VAL A   7
ILE A 256
GLY A 171
ILE A 237
 None
 1.40A 2r5pB-4ls5A:
undetectable		 2r5pB-4ls5A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 ILE A 256
LEU A  10
ILE A 170
PHE A 407
 None
GOL  A 503 ( 4.7A)
None
None
 0.84A 2w9sE-4ls5A:
undetectable		 2w9sE-4ls5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ALA A 234
GLY A 345
GLY A 166
VAL A 186
ILE A 236
 None
 0.84A 3cyxB-4ls5A:
undetectable		 3cyxB-4ls5A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.97A 3drcB-4ls5A:
undetectable		 3drcB-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 10 GLY A 346
ALA A 349
VAL A   7
ILE A 256
GLY A 171
ILE A 237
 None
 1.43A 3ekpD-4ls5A:
undetectable		 3ekpD-4ls5A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 GLY A 346
ALA A 349
VAL A   7
ILE A 256
GLY A 171
ILE A 237
 None
 1.42A 3el1B-4ls5A:
undetectable		 3el1B-4ls5A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELW_A_SAMA4633_0
(METHYLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 GLY A 107
GLY A 346
GLY A 166
GLY A 105
PHE A 351
ILE A 347
 None
 1.31A 3elwA-4ls5A:
undetectable		 3elwA-4ls5A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL3_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.04A 3ql3A-4ls5A:
undetectable		 3ql3A-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ALA A 207
PHE A 228
ILE A 108
LEU A 341
GLY A 201
 None
 1.06A 3rukB-4ls5A:
undetectable		 3rukB-4ls5A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.00A 4dfrB-4ls5A:
undetectable		 4dfrB-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 TYR A 298
GLY A 345
SER A 395
GLY A 397
LEU A 396
 None
None
K  A 501 ( 4.8A)
None
None
 1.05A 4e1gB-4ls5A:
undetectable		 4e1gB-4ls5A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 346
GLY A 345
VAL A 186
ILE A 170
PHE A 407
 None
 1.12A 4fglA-4ls5A:
undetectable
4fglB-4ls5A:
undetectable		 4fglA-4ls5A:
18.98
4fglB-4ls5A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.02A 4kjlA-4ls5A:
undetectable		 4kjlA-4ls5A:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		11 / 12 GLY A 107
ALA A 162
CYH A 163
GLU A 191
SER A 198
PHE A 202
HIS A 302
THR A 304
HIS A 339
LEU A 341
GLY A 397
 None
 0.52A 4ls7A-4ls5A:
79.0		 4ls7A-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		8 / 12 GLY A 107
ALA A 162
GLU A 191
SER A 198
PHE A 202
LEU A 341
GLY A 397
PHE A 398
 None
 0.85A 4ls7A-4ls5A:
79.0		 4ls7A-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		8 / 12 GLY A 342
ALA A 162
CYH A 163
GLU A 191
SER A 198
PHE A 202
LEU A 341
GLY A 397
 None
 1.45A 4ls7A-4ls5A:
79.0		 4ls7A-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 342
SER A 198
PHE A 202
THR A 306
GLY A 397
 None
 0.78A 4ls7A-4ls5A:
79.0		 4ls7A-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		9 / 12 ALA A 162
CYH A 163
SER A 198
PHE A 202
HIS A 302
THR A 304
HIS A 339
LEU A 341
GLY A 397
 None
 0.56A 4ls7A-4ls5A:
79.0
4ls7B-4ls5A:
77.7		 4ls7A-4ls5A:
100.00
4ls7B-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 ALA A 162
SER A 198
PHE A 202
LEU A 341
GLY A 397
PHE A 398
 None
 0.91A 4ls7A-4ls5A:
79.0
4ls7B-4ls5A:
77.7		 4ls7A-4ls5A:
100.00
4ls7B-4ls5A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 ILE A 108
ALA A 162
CYH A 163
HIS A 302
THR A 304
GLY A 397
 None
 0.83A 4ls7A-4ls5A:
79.0
4ls7B-4ls5A:
77.7		 4ls7A-4ls5A:
100.00
4ls7B-4ls5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 296
ILE A 237
LEU A 239
GLY A 254
ILE A 353
 None
 1.19A 4o1eB-4ls5A:
undetectable		 4o1eB-4ls5A:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.04A 4pthA-4ls5A:
undetectable		 4pthA-4ls5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.07A 4ptjA-4ls5A:
undetectable		 4ptjA-4ls5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 ALA A  77
ILE A 138
GLY A 109
SER A 169
 None
 0.77A 4r20A-4ls5A:
undetectable		 4r20A-4ls5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 6 ALA A 349
GLY A 171
ILE A 353
VAL A   5
 None
 0.76A 4r21A-4ls5A:
undetectable		 4r21A-4ls5A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.01A 4x5gB-4ls5A:
undetectable		 4x5gB-4ls5A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 188
ILE A 317
GLY A 278
THR A 262
PHE A 407
 None
 1.14A 4zdyA-4ls5A:
undetectable		 4zdyA-4ls5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 5 THR A 262
GLY A 277
GLU A 313
HIS A 302
 None
 1.17A 5c0oH-4ls5A:
undetectable		 5c0oH-4ls5A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.95A 5e8qA-4ls5A:
undetectable		 5e8qA-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 188
ILE A 317
GLY A 278
THR A 262
PHE A 407
 None
 1.15A 5eslA-4ls5A:
undetectable		 5eslA-4ls5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 6 GLY A 189
THR A 190
SER A 169
VAL A 104
 None
 0.99A 5ewuB-4ls5A:
undetectable		 5ewuB-4ls5A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		6 / 12 ALA A  12
GLY A 233
GLY A 346
GLY A  17
SER A  23
LEU A 354
 None
None
None
None
None
GOL  A 503 (-4.9A)
 1.23A 5gwxA-4ls5A:
undetectable		 5gwxA-4ls5A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 188
THR A 165
ALA A  77
ALA A 142
ILE A 146
 None
 0.72A 5kb6A-4ls5A:
undetectable		 5kb6A-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_A_ADNA401_1
(ADENOSINE KINASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 231
ALA A 343
GLY A 342
ALA A 344
ILE A 347
 None
 0.85A 5kb6A-4ls5A:
undetectable		 5kb6A-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB6_B_ADNB401_1
(ADENOSINE KINASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 GLY A 231
ALA A 343
GLY A 342
ALA A 344
ILE A 347
 None
 0.84A 5kb6B-4ls5A:
undetectable		 5kb6B-4ls5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ALA A  80
VAL A  79
GLU A 348
ALA A  51
PHE A  56
 None
None
K  A 501 (-3.5A)
None
None
 1.17A 5n5dA-4ls5A:
undetectable		 5n5dA-4ls5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ALA A  80
VAL A  79
GLU A 348
ALA A  51
PHE A  56
 None
None
K  A 501 (-3.5A)
None
None
 1.07A 5n5dB-4ls5A:
undetectable		 5n5dB-4ls5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_B_SAMB501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 9 LEU A 340
ILE A 347
GLY A 346
GLY A 188
LEU A  13
 None
 0.98A 5o96A-4ls5A:
undetectable
5o96B-4ls5A:
undetectable		 5o96A-4ls5A:
21.97
5o96B-4ls5A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 0.98A 5ujxA-4ls5A:
undetectable		 5ujxA-4ls5A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 9 VAL A 104
LEU A  13
ALA A  12
VAL A  20
SER A  23
 None
None
None
GOL  A 503 ( 4.8A)
None
 1.27A 6c2mB-4ls5A:
undetectable		 6c2mB-4ls5A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		4 / 8 TYR A 253
ALA A  88
VAL A  85
ASP A  21
 None
None
None
GOL  A 503 (-2.8A)
 1.03A 6hu9a-4ls5A:
undetectable
6hu9e-4ls5A:
undetectable		 6hu9a-4ls5A:
22.53
6hu9e-4ls5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Bacillus
subtilis) 		5 / 12 ILE A 237
ALA A  88
ILE A 146
ILE A 236
THR A   8
 None
 1.04A 7dfrA-4ls5A:
undetectable		 7dfrA-4ls5A:
16.29