SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ls9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_B_MTXB171_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 132
ALA A 145
LEU A  59
ILE A 133
THR A 144
 None
 1.01A 1d1gB-4ls9A:
undetectable		 1d1gB-4ls9A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 0.96A 1dhiA-4ls9A:
undetectable		 1dhiA-4ls9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 0.97A 1dhiB-4ls9A:
undetectable		 1dhiB-4ls9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 0.98A 1dhjA-4ls9A:
undetectable		 1dhjA-4ls9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 0.97A 1dhjB-4ls9A:
undetectable		 1dhjB-4ls9A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.00A 1draB-4ls9A:
undetectable		 1draB-4ls9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.02A 1drbB-4ls9A:
undetectable		 1drbB-4ls9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		3 / 4 VAL A 295
TRP A 258
TRP A 293
 None
 1.22A 1gmkA-4ls9A:
undetectable
1gmkB-4ls9A:
undetectable		 1gmkA-4ls9A:
5.06
1gmkB-4ls9A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 4 GLY A 247
LEU A 243
GLY A 245
ARG A 246
 None
 1.36A 1j7kA-4ls9A:
undetectable		 1j7kA-4ls9A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.01A 1rb2A-4ls9A:
undetectable		 1rb2A-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.08A 1rb2B-4ls9A:
undetectable		 1rb2B-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.00A 1rd7A-4ls9A:
undetectable		 1rd7A-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.00A 1rx2A-4ls9A:
undetectable		 1rx2A-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_B_STRB402_1
(MINERALOCORTICOID
RECEPTOR)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  63
ALA A  60
LEU A 162
LEU A 178
CYH A 177
 None
 1.49A 2aa6B-4ls9A:
undetectable		 2aa6B-4ls9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 0.96A 2d0kA-4ls9A:
undetectable		 2d0kA-4ls9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.02A 2drcB-4ls9A:
undetectable		 2drcB-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_A_ZMRA1776_2
(NEURAMINIDASE A)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 190
ASP A 271
ILE A 272
LEU A 229
 None
 0.92A 2ya7A-4ls9A:
undetectable		 2ya7A-4ls9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_B_ZMRB1776_2
(NEURAMINIDASE A)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 190
ASP A 271
ILE A 272
LEU A 229
 None
 0.91A 2ya7B-4ls9A:
undetectable		 2ya7B-4ls9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_D_ZMRD1776_2
(NEURAMINIDASE A)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ARG A 190
ASP A 271
ILE A 272
LEU A 229
 None
 0.92A 2ya7D-4ls9A:
undetectable		 2ya7D-4ls9A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 VAL A 273
VAL A 270
THR A 235
THR A 275
 None
 1.28A 3bjwD-4ls9A:
undetectable		 3bjwD-4ls9A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 132
ALA A 145
LEU A  59
ILE A 133
THR A 144
 None
 1.03A 3clbA-4ls9A:
2.3		 3clbA-4ls9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 VAL A 132
ALA A 145
LEU A  59
ILE A 133
THR A 144
 None
 1.05A 3clbC-4ls9A:
2.7		 3clbC-4ls9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.02A 3drcB-4ls9A:
undetectable		 3drcB-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 VAL A 132
ALA A 145
LEU A  59
ILE A 133
THR A 144
 None
 1.04A 3hbbC-4ls9A:
2.2		 3hbbC-4ls9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 GLN A 278
GLY A 247
ARG A 274
ALA A 282
ALA A 283
 None
 1.10A 3keeD-4ls9A:
undetectable		 3keeD-4ls9A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 108
ASN A 139
GLY A 143
ALA A 145
ALA A  30
 None
 1.03A 3p5nB-4ls9A:
undetectable		 3p5nB-4ls9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 THR A 108
ASN A 139
GLY A 143
ALA A 145
LEU A  33
 None
 1.07A 3p5nB-4ls9A:
undetectable		 3p5nB-4ls9A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.03A 3tq9A-4ls9A:
undetectable		 3tq9A-4ls9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 11 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.12A 3tqbA-4ls9A:
undetectable		 3tqbA-4ls9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.02A 4dfrB-4ls9A:
undetectable		 4dfrB-4ls9A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.00A 4pstA-4ls9A:
undetectable		 4pstA-4ls9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ALA A 145
LEU A 105
LEU A  59
ILE A 133
THR A 144
 None
 1.00A 4x5gB-4ls9A:
undetectable		 4x5gB-4ls9A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XOY_A_DX4A401_0
(MITOGEN-ACTIVATED
PROTEIN KINASE 1)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 6 ALA A  60
GLN A  61
LEU A  63
LEU A 163
 None
 1.11A 4xoyA-4ls9A:
undetectable		 4xoyA-4ls9A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 7 PHE A 248
LEU A 239
ALA A 336
GLN A 278
 None
 1.24A 6b89A-4ls9A:
undetectable		 6b89A-4ls9A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_A_ACTA204_0
(N-ACETYLTRANSFERASE)		 4ls9 DHH FAMILY PROTEIN
(Mycolicibacteriu
m
smegmatis) 		4 / 5 LEU A 178
THR A 156
THR A 183
GLY A 181
 None
 1.12A 6gtqA-4ls9A:
undetectable		 6gtqA-4ls9A:
17.89