SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_C_TRPC81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A 139
GLY A  91
ALA A 140
THR A 102
ILE A 116
 None
 1.23A 1gtnB-4lsbA:
undetectable
1gtnC-4lsbA:
undetectable		 1gtnB-4lsbA:
15.42
1gtnC-4lsbA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_I_TRPI81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 10 ALA A 139
GLY A  91
ALA A 140
THR A 102
ILE A 116
 None
 1.23A 1gtnH-4lsbA:
undetectable
1gtnI-4lsbA:
undetectable		 1gtnH-4lsbA:
15.42
1gtnI-4lsbA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 10 LEU A 185
ALA A 140
ALA A 182
VAL A 203
ASP A 118
 None
 1.04A 1rlbE-4lsbA:
undetectable		 1rlbE-4lsbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 9 ARG A 239
GLY A  52
SER A  50
THR A 191
VAL A 209
 CL  A 502 (-4.3A)
None
MG  A 501 (-2.5A)
None
None
 1.22A 2nnhB-4lsbA:
undetectable		 2nnhB-4lsbA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 119
ASP A  87
PRO A 188
LEU A 185
ASP A 118
 None
MG  A 501 ( 4.1A)
None
None
None
 1.19A 2nv4A-4lsbA:
undetectable		 2nv4A-4lsbA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 12 ALA A 119
ASP A  87
PRO A 188
LEU A 185
ASP A 118
 None
MG  A 501 ( 4.1A)
None
None
None
 1.24A 2nv4B-4lsbA:
undetectable		 2nv4B-4lsbA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		3 / 3 ASN A  28
ASP A  87
ARG A 165
 None
MG  A 501 ( 4.1A)
None
 0.95A 3k13C-4lsbA:
9.2		 3k13C-4lsbA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 190
TYR A 160
ALA A 198
ALA A 182
TYR A 177
 None
 1.00A 3ozuA-4lsbA:
2.2		 3ozuA-4lsbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 12 ILE A 190
TYR A 160
ALA A 198
VAL A 203
ALA A 182
 None
 1.32A 3ozuA-4lsbA:
2.2		 3ozuA-4lsbA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		4 / 5 PRO A  29
ASN A  28
ILE A  26
VAL A 210
 None
 1.44A 4hytA-4lsbA:
undetectable		 4hytA-4lsbA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		4 / 8 ILE A  26
GLY A 114
THR A 154
LEU A  88
 None
 0.92A 5hwaA-4lsbA:
undetectable		 5hwaA-4lsbA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKW_A_TESA601_1
(AROMATASE)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		5 / 11 ILE A 190
ILE A 171
THR A 200
VAL A 228
VAL A 231
 None
 1.42A 5jkwA-4lsbA:
undetectable		 5jkwA-4lsbA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		4 / 5 ALA A 111
ALA A  86
ILE A  73
LEU A  70
 None
 0.52A 5jncD-4lsbA:
undetectable		 5jncD-4lsbA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		4 / 6 TYR A 177
ILE A 137
ALA A 132
ARG A 130
 None
 1.12A 6hu9m-4lsbA:
undetectable
6hu9q-4lsbA:
undetectable		 6hu9m-4lsbA:
18.63
6hu9q-4lsbA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lsb LYASE/MUTASE
(Burkholderia
cenocepacia) 		4 / 6 TYR A 177
ILE A 137
ALA A 132
ASP A 169
 None
 0.90A 6hu9m-4lsbA:
undetectable
6hu9q-4lsbA:
undetectable		 6hu9m-4lsbA:
18.63
6hu9q-4lsbA:
17.99