SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 7 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 0.91A 1dssG-4lsmA:
51.7		 1dssG-4lsmA:
60.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		7 / 7 SER A 155
THR A 157
ASN A 159
CYH A 160
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.18A 1dssG-4lsmA:
51.7		 1dssG-4lsmA:
60.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 8 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 0.90A 1dssR-4lsmA:
51.5		 1dssR-4lsmA:
60.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		8 / 8 SER A 155
THR A 157
ASN A 159
CYH A 160
HIS A 183
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.36A 1dssR-4lsmA:
51.5		 1dssR-4lsmA:
60.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4003_1
(SERUM ALBUMIN)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 9 ILE A 174
VAL A 221
GLY A 222
ALA A 165
LEU A 161
 None
 1.00A 1e7bA-4lsmA:
undetectable		 1e7bA-4lsmA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ALA A  26
LEU A 329
ALA A 333
ILE A  35
ILE A  33
 None
 1.03A 1fk6A-4lsmA:
undetectable		 1fk6A-4lsmA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_1
(HIV-II PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ALA A  27
ILE A  11
VAL A 332
ILE A  38
ILE A  35
 None
 0.87A 1hshA-4lsmA:
undetectable		 1hshA-4lsmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 9 ALA A  27
ILE A  11
VAL A 332
ILE A  38
ILE A  35
 None
 0.80A 1hshB-4lsmA:
undetectable		 1hshB-4lsmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 7 PHE A  16
VAL A  73
VAL A  80
ILE A  38
 None
 0.87A 1p7rA-4lsmA:
undetectable		 1p7rA-4lsmA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9W_A_NFNA6002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 7 ALA A 118
PHE A 106
ARG A  84
ASN A  88
 None
 1.27A 1t9wA-4lsmA:
2.6		 1t9wA-4lsmA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 5 LEU A 253
GLY A 173
HIS A 169
ILE A 168
 None
 0.76A 1xf1A-4lsmA:
undetectable		 1xf1A-4lsmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 6 LEU A 253
GLY A 173
HIS A 169
ILE A 168
 None
 0.71A 1xf1B-4lsmA:
undetectable		 1xf1B-4lsmA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 4 ALA A  48
TYR A  49
ALA A  44
TYR A  46
 None
 1.24A 2wlkA-4lsmA:
1.4
2wlkB-4lsmA:
1.2		 2wlkA-4lsmA:
20.59
2wlkB-4lsmA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 6 SER A 306
GLU A 260
TYR A 259
CYH A 263
 None
 1.47A 2x7hA-4lsmA:
4.4		 2x7hA-4lsmA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 GLY A 304
ALA A 251
ILE A 168
LEU A 164
LEU A 161
 None
 0.98A 3adxB-4lsmA:
undetectable		 3adxB-4lsmA:
21.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 8 ASN A 320
TYR A 324
ASN A 159
TYR A 318
 NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
None
None
 0.92A 3dmtC-4lsmA:
49.3		 3dmtC-4lsmA:
49.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		8 / 8 SER A 155
THR A 157
ASN A 159
CYH A 160
HIS A 183
TYR A 318
ASN A 320
TYR A 324
 None
None
None
None
None
None
NAD  A 401 (-3.7A)
NAD  A 401 (-3.6A)
 0.30A 3dmtC-4lsmA:
49.3		 3dmtC-4lsmA:
49.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 11 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
 None
None
NAD  A 401 (-4.0A)
None
None
 0.91A 3ebzA-4lsmA:
undetectable		 3ebzA-4lsmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 9 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
 None
None
NAD  A 401 (-4.0A)
None
None
 0.95A 3s43A-4lsmA:
undetectable		 3s43A-4lsmA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_1
(PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 9 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
 None
None
NAD  A 401 (-4.0A)
None
None
 0.88A 3s45A-4lsmA:
undetectable		 3s45A-4lsmA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_2
(PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 11 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
 None
None
NAD  A 401 (-4.0A)
None
None
 0.90A 3s53B-4lsmA:
undetectable		 3s53B-4lsmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		3 / 3 ASN A 243
ASP A 319
ASN A 320
 None
None
NAD  A 401 (-3.7A)
 0.74A 4agaA-4lsmA:
undetectable		 4agaA-4lsmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ASP A  54
THR A 241
THR A 185
ALA A 184
ASN A 320
 None
None
None
None
NAD  A 401 (-3.7A)
 1.48A 4u15B-4lsmA:
undetectable		 4u15B-4lsmA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ASN A  92
GLY A  12
ILE A  13
ILE A  78
GLN A  28
 None
 1.09A 4xucA-4lsmA:
3.9		 4xucA-4lsmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 11 GLY A 304
ALA A 251
ILE A 168
LEU A 164
LEU A 161
 None
 0.96A 4xumB-4lsmA:
undetectable		 4xumB-4lsmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_1
(PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ALA A  27
ILE A  11
VAL A 332
ILE A  38
ILE A  35
 None
 0.78A 5e5jA-4lsmA:
undetectable		 5e5jA-4lsmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5K_B_017B201_2
(HIV-1 PROTEASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 ALA A  27
ILE A  11
ILE A  19
ILE A  38
ILE A  35
 None
None
NAD  A 401 (-4.0A)
None
None
 0.89A 5e5kB-4lsmA:
undetectable		 5e5kB-4lsmA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		3 / 3 THR A 158
ALA A 154
ASN A 159
 None
 0.55A 5ersA-4lsmA:
3.6		 5ersA-4lsmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JHD_E_EDTE301_0
(BETA-2-MICROGLOBULIN
TCRBETA CHAIN)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 8 TYR A 324
SER A 155
THR A 157
PRO A 129
 NAD  A 401 (-3.6A)
None
None
None
 0.96A 5jhdE-4lsmA:
undetectable
5jhdG-4lsmA:
undetectable		 5jhdE-4lsmA:
20.22
5jhdG-4lsmA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 6 PHE A 237
VAL A 182
ALA A 236
THR A 157
 None
 1.03A 5t7bA-4lsmA:
3.7		 5t7bA-4lsmA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA605_0
(ALPHA-AMYLASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 8 GLY A  20
ILE A  19
ASP A  54
HIS A  57
 None
NAD  A 401 (-4.0A)
None
None
 0.94A 6ag0A-4lsmA:
undetectable		 6ag0A-4lsmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		4 / 8 GLY A  20
ILE A  19
ASP A  54
HIS A  57
 None
NAD  A 401 (-4.0A)
None
None
 0.96A 6ag0C-4lsmA:
undetectable		 6ag0C-4lsmA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 GLY A  37
GLY A  12
VAL A 100
GLN A  28
VAL A 332
 None
 1.03A 6gneA-4lsmA:
4.9		 6gneA-4lsmA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4lsm GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC
(Trypanosoma
cruzi) 		5 / 12 GLY A  37
GLY A  12
VAL A 100
GLN A  28
VAL A 332
 None
 1.03A 6gneB-4lsmA:
4.3		 6gneB-4lsmA:
20.35