SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens;
Homo
sapiens) 		3 / 3 ALA H 100
VAL L  48
TRP L  35
 None
 0.90A 1c4dC-4lsqH:
undetectable
1c4dD-4lsqH:
undetectable		 1c4dC-4lsqH:
5.62
1c4dD-4lsqH:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 4lsq LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens) 		4 / 7 LEU L 135
THR L 172
SER L 162
THR L 164
 None
 0.79A 1ictD-4lsqL:
undetectable		 1ictD-4lsqL:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1867_0
(FPRA)		 4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.75A 1lqtB-4lsqH:
undetectable		 1lqtB-4lsqH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1424_0
(FPRA)		 4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
(Homo
sapiens) 		4 / 4 ALA H  40
ARG H  38
GLN H  43
GLU H  46
 None
 0.77A 1lquB-4lsqH:
undetectable		 1lquB-4lsqH:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 4lsq LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens) 		4 / 5 LEU L 179
GLY L 128
PRO L 120
VAL L 132
 None
 0.86A 2aojA-4lsqL:
undetectable		 2aojA-4lsqL:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
(Homo
sapiens) 		4 / 4 THR H  19
THR H  70
ASP H  72
ASP H  27
 None
 1.50A 2f8lA-4lsqH:
undetectable		 2f8lA-4lsqH:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WFA_B_EDTB802_0
(ALPHA-GLUCOSIDASE)		 4lsq HEAVY CHAIN OF
ANTIBODY VRC-CH31
LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens;
Homo
sapiens) 		4 / 6 TYR L  91
ASP L  50
ASN L  34
TYR H 100
 None
 1.49A 3wfaA-4lsqL:
undetectable
3wfaB-4lsqL:
undetectable		 3wfaA-4lsqL:
15.12
3wfaB-4lsqL:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lsq LIGHT CHAIN OF
ANTIBODY VRC-CH31
WITH N70D MUTATION
(Homo
sapiens) 		4 / 6 LEU L 175
GLU L 143
VAL L 110
ALA L 111
 None
 1.11A 4nkvC-4lsqL:
undetectable		 4nkvC-4lsqL:
18.16