SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lss'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 8 GLY G 222
THR G 244
ILE G 491
GLN G 246
 None
 1.04A 2a8tB-4lssG:
undetectable		 2a8tB-4lssG:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I00_A_ZMRA509_2
(NEURAMINIDASE)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 5 LEU G 416
TRP G 338
ILE G 452
ASN G 478
 None
 1.48A 4i00A-4lssG:
undetectable		 4i00A-4lssG:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 7 GLU G 466
ASN G 280
ILE G 277
TRP G 353
 None
None
NAG  G 502 ( 4.6A)
None
 1.20A 4ii8A-4lssG:
undetectable		 4ii8A-4lssG:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		5 / 11 ILE G 215
ALA G  55
LEU G  52
LEU G 483
ILE G 251
 None
 1.10A 4p66A-4lssG:
undetectable		 4p66A-4lssG:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		3 / 3 TYR G 486
LYS G 485
LYS G 227
 None
 1.19A 5dbyA-4lssG:
undetectable		 5dbyA-4lssG:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4lss ENVELOPE
GLYCOPROTEIN GP120
(Human
immunodeficiency
virus
1) 		4 / 6 PHE G 468
ARG G 350
THR G 358
ILE G 360
 None
None
NAG  G 512 (-2.8A)
None
 1.43A 5ih0A-4lssG:
undetectable		 5ih0A-4lssG:
20.48