SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens;
Homo
sapiens) 		3 / 4 VAL L  48
TRP H 103
TRP L  35
 None
 1.44A 1gmkC-4lsuL:
undetectable
1gmkD-4lsuL:
undetectable		 1gmkC-4lsuL:
5.03
1gmkD-4lsuL:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens;
Homo
sapiens) 		5 / 12 PHE H 100
ALA L  26
SER L  27
ALA L  71
GLY L  25
 None
 1.16A 2igtC-4lsuH:
undetectable		 2igtC-4lsuH:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_A_DIFA1_1
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.06A 3cfqA-4lsuL:
3.0		 3cfqA-4lsuL:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBR_A_ASDA129_1
(STEROID
DELTA-ISOMERASE)		 4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		5 / 12 PHE H 166
VAL L 195
VAL L 144
PRO L 113
PHE L 139
 None
 1.47A 3nbrA-4lsuH:
undetectable		 3nbrA-4lsuH:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		3 / 3 ARG H  94
HIS H 102
TYR H  32
 None
EDO  H 301 ( 4.5A)
None
 1.12A 4fu8A-4lsuH:
undetectable		 4fu8A-4lsuH:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4lsu HEAVY CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		3 / 3 ARG H  94
HIS H 102
TYR H  32
 None
EDO  H 301 ( 4.5A)
None
 1.14A 4fu9A-4lsuH:
undetectable		 4fu9A-4lsuH:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.04A 4i89A-4lsuL:
3.1		 4i89A-4lsuL:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.06A 4ikiB-4lsuL:
undetectable		 4ikiB-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 7 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.04A 4iklA-4lsuL:
undetectable
4iklB-4lsuL:
undetectable		 4iklA-4lsuL:
24.51
4iklB-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.02A 5bojA-4lsuL:
undetectable		 5bojA-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 0.98A 5l4iA-4lsuL:
undetectable		 5l4iA-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		4 / 6 LEU L 132
ALA L 130
LEU L 178
THR L 181
 None
 1.00A 5l4iB-4lsuL:
undetectable		 5l4iB-4lsuL:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 4lsu LIGHT CHAIN OF
ANTIBODY VRC-PG20
(Homo
sapiens) 		3 / 3 ARG L  54
ILE L  58
SER L  59
 None
 0.89A 5zw2A-4lsuL:
undetectable		 5zw2A-4lsuL:
19.19