SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KB9_A_PCFA514_0
(CYTOCHROME B
CYTOCHROME C1, HEME
PROTEIN
UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN I
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		4 / 8 PHE A 167
VAL A 109
MET A 112
SER A 116
 None
 1.15A 1kb9A-4lswA:
undetectable
1kb9C-4lswA:
undetectable
1kb9D-4lswA:
undetectable
1kb9E-4lswA:
undetectable		 1kb9A-4lswA:
22.35
1kb9C-4lswA:
23.27
1kb9D-4lswA:
23.19
1kb9E-4lswA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 10 GLY A 285
ILE A 232
ILE A 156
GLY A 102
ALA A 110
 None
 1.03A 1sh9B-4lswA:
undetectable		 1sh9B-4lswA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXM_A_IMNA2002_1
(SERUM ALBUMIN)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 11 ARG A 290
LEU A 100
ILE A 156
PHE A 202
GLY A 108
 None
 1.27A 2bxmA-4lswA:
undetectable		 2bxmA-4lswA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2003_1
(SERUM ALBUMIN)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 10 ARG A 290
LEU A 100
ILE A 156
PHE A 202
GLY A 108
 None
 1.17A 2bxqA-4lswA:
undetectable		 2bxqA-4lswA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		3 / 3 VAL A 259
ASP A 258
GLU A 263
 None
 0.62A 2qeuA-4lswA:
undetectable		 2qeuA-4lswA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		3 / 3 VAL A 259
ASP A 258
GLU A 263
 None
 0.62A 2qeuC-4lswA:
undetectable		 2qeuC-4lswA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_0
(REPRESSOR PROTEIN
MPHR(A))		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 LEU A 100
SER A 284
SER A 236
VAL A  76
ILE A 156
 None
 1.19A 3frqA-4lswA:
undetectable		 3frqA-4lswA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 PRO A 280
GLY A 108
ARG A 163
VAL A 160
ILE A 156
 None
 1.39A 3jb2A-4lswA:
4.9		 3jb2A-4lswA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 VAL A 109
LEU A 164
SER A 233
ILE A 156
GLY A 102
 None
 1.10A 3kk6A-4lswA:
undetectable		 3kk6A-4lswA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 VAL A 109
LEU A 164
SER A 233
ILE A 156
GLY A 102
 None
 1.08A 3kk6B-4lswA:
undetectable		 3kk6B-4lswA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_A_T1CA404_1
(TETX2 PROTEIN)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 PHE A 202
ASN A 231
GLY A 108
GLY A 227
MET A 169
 None
 1.17A 3v3oA-4lswA:
3.4		 3v3oA-4lswA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1004_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 11 ALA A 148
LEU A 205
VAL A 109
LEU A 164
GLY A 157
 None
 1.15A 3zosA-4lswA:
undetectable
3zosB-4lswA:
undetectable		 3zosA-4lswA:
24.07
3zosB-4lswA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FR0_A_SAMA401_0
(ARSENIC
METHYLTRANSFERASE)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 GLY A 108
MET A 112
LEU A 113
PHE A 200
VAL A 160
 None
 1.09A 4fr0A-4lswA:
5.4		 4fr0A-4lswA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		4 / 6 LEU A 243
GLU A 221
VAL A 192
ALA A 191
 None
 1.15A 4nkvC-4lswA:
undetectable		 4nkvC-4lswA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		4 / 4 LEU A 301
ARG A  47
ILE A   6
PHE A  24
 None
 1.35A 5kirB-4lswA:
0.0		 5kirB-4lswA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 THR A 193
VAL A 219
VAL A 150
LEU A 151
HIS A 213
 None
 0.99A 5kocB-4lswA:
5.4		 5kocB-4lswA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 10 ARG A 251
ALA A 246
LEU A 252
GLY A 224
LEU A 107
 None
 1.25A 5oy01-4lswA:
undetectable
5oy07-4lswA:
undetectable		 5oy01-4lswA:
16.26
5oy07-4lswA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 GLY A 149
GLY A 152
VAL A 188
ILE A 156
ALA A 206
 None
 1.24A 5x7fA-4lswA:
6.4		 5x7fA-4lswA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4lsw D-2-HYDROXYACID
DEHYDROGENSASE
PROTEIN
(Ketogulonicigeni
um
vulgare) 		5 / 12 VAL A 259
LEU A 257
VAL A 203
VAL A 276
LEU A 229
 None
 1.07A 6ajiA-4lswA:
undetectable		 6ajiA-4lswA:
17.32