SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4lsz DARPIN D7.18
(synthetic
construct) 		4 / 8 LYS E 147
ASP E 143
SER E 153
ASN E 156
 None
 0.93A 3lm8A-4lszE:
undetectable
3lm8C-4lszE:
undetectable		 3lm8A-4lszE:
21.58
3lm8C-4lszE:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 4lsz DARPIN D7.18
(synthetic
construct) 		5 / 11 ILE E  62
LEU E  51
HIS E  69
LEU E  67
ALA E  71
 None
 1.11A 4p65E-4lszE:
undetectable
4p65F-4lszE:
undetectable
4p65J-4lszE:
undetectable
4p65L-4lszE:
undetectable		 4p65E-4lszE:
7.78
4p65F-4lszE:
15.45
4p65J-4lszE:
15.45
4p65L-4lszE:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4lsz DARPIN D7.18
(synthetic
construct) 		5 / 12 VAL E  30
LEU E  18
LEU E  51
ILE E  62
ALA E  71
 None
 0.99A 4p65B-4lszE:
undetectable
4p65D-4lszE:
undetectable
4p65I-4lszE:
undetectable
4p65J-4lszE:
undetectable		 4p65B-4lszE:
15.45
4p65D-4lszE:
15.45
4p65I-4lszE:
7.78
4p65J-4lszE:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 4lsz DARPIN D7.18
(synthetic
construct) 		5 / 12 VAL E  96
LEU E  84
LEU E 117
ILE E 128
ALA E 137
 None
 1.02A 4p65B-4lszE:
undetectable
4p65D-4lszE:
undetectable
4p65I-4lszE:
undetectable
4p65J-4lszE:
undetectable		 4p65B-4lszE:
15.45
4p65D-4lszE:
15.45
4p65I-4lszE:
7.78
4p65J-4lszE:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 4lsz DARPIN D7.18
(synthetic
construct) 		3 / 3 ASP E 123
ASN E 118
PHE E 145
 None
 0.66A 5dsgB-4lszE:
undetectable		 5dsgB-4lszE:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4lsz DARPIN D7.18
(synthetic
construct) 		4 / 4 ILE E  62
LEU E  51
HIS E  69
ALA E  71
 None
 1.05A 6ck2C-4lszE:
undetectable
6ck2D-4lszE:
undetectable		 6ck2C-4lszE:
7.78
6ck2D-4lszE:
14.75