SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lt5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		4 / 7 LEU A 292
TYR A 165
GLY A 163
TYR A 294
 None
 1.02A 1lweA-4lt5A:
undetectable		 1lweA-4lt5A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		5 / 12 HIS A 229
ASP A 231
LEU A 253
HIS A 279
VAL A 293
 MN  A 401 ( 3.4A)
MN  A 401 ( 2.7A)
OGA  A 413 (-3.8A)
MN  A 401 ( 3.4A)
OGA  A 413 (-4.9A)
 0.68A 1uobA-4lt5A:
8.2		 1uobA-4lt5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		5 / 11 HIS A 229
ASP A 231
HIS A 279
VAL A 281
VAL A 293
 MN  A 401 ( 3.4A)
MN  A 401 ( 2.7A)
MN  A 401 ( 3.4A)
OGA  A 413 (-4.8A)
OGA  A 413 (-4.9A)
 0.60A 1uofA-4lt5A:
2.7		 1uofA-4lt5A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		3 / 3 LEU A 314
HIS A 317
LYS A 318
 None
 1.10A 1y7iA-4lt5A:
undetectable		 1y7iA-4lt5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_K_BEZK4387_0
(CES1 PROTEIN)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		3 / 3 TRP A  90
LEU A  85
LYS A  59
 None
 1.35A 1yajK-4lt5A:
undetectable		 1yajK-4lt5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		4 / 6 VAL A 293
ASP A 234
HIS A 297
ASN A 214
 OGA  A 413 (-4.9A)
None
None
OGA  A 413 (-3.3A)
 1.36A 2zs9A-4lt5A:
undetectable		 2zs9A-4lt5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVO_A_PAUA314_0
(PANTOTHENATE KINASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		5 / 11 VAL A 293
ASP A 234
HIS A 297
ILE A 225
ASN A 214
 OGA  A 413 (-4.9A)
None
None
OGA  A 413 (-4.1A)
OGA  A 413 (-3.3A)
 1.49A 3avoA-4lt5A:
undetectable		 3avoA-4lt5A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		5 / 12 LEU A 292
GLY A 291
PHE A 241
PHE A 124
THR A 125
 None
 0.98A 3dh0A-4lt5A:
undetectable		 3dh0A-4lt5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lt5 NAEGLERIA TET-LIKE
DIOXYGENASE
(Naegleria
gruberi) 		4 / 8 THR A 189
LEU A 182
SER A 239
ASN A 275
 EDO  A 406 ( 4.5A)
None
None
None
 1.03A 3kp2A-4lt5A:
undetectable
3kp2B-4lt5A:
undetectable		 3kp2A-4lt5A:
19.38
3kp2B-4lt5A:
19.38