SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lt6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 7 TRP A 229
GLU A 339
ILE A 235
LEU A 360
 None
 1.41A 1q0yH-4lt6A:
undetectable
1q0yL-4lt6A:
undetectable		 1q0yH-4lt6A:
19.38
1q0yL-4lt6A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_A_ACTA1117_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		3 / 3 ASP A 193
ARG A 171
ARG A 125
 None
 1.01A 2j9dA-4lt6A:
5.0
2j9dC-4lt6A:
4.4		 2j9dA-4lt6A:
14.00
2j9dC-4lt6A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 7 PHE A 132
GLY A  93
PHE A 160
PHE A 158
 None
 1.11A 3ko0K-4lt6A:
undetectable
3ko0S-4lt6A:
undetectable		 3ko0K-4lt6A:
12.50
3ko0S-4lt6A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		5 / 10 ALA A 170
PHE A 128
ILE A 156
ALA A 147
ALA A 151
 None
 1.04A 4j14A-4lt6A:
undetectable		 4j14A-4lt6A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA303_1
(CHITOSANASE)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 6 ASP A 207
ARG A 103
GLY A 100
VAL A 106
 None
None
3AT  A 601 (-3.5A)
None
 1.08A 4oltA-4lt6A:
0.6		 4oltA-4lt6A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		3 / 3 PRO A 497
VAL A 433
HIS A 386
 None
 0.82A 4pevC-4lt6A:
undetectable		 4pevC-4lt6A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0P_A_TE4A201_1
(BETA-LACTOGLOBULIN)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		5 / 12 LEU A  61
LEU A 167
ILE A 165
ILE A 113
VAL A  71
 None
 1.16A 4y0pA-4lt6A:
undetectable		 4y0pA-4lt6A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		5 / 12 THR A  98
LEU A 116
ALA A 115
GLY A  65
LEU A  64
 None
 0.95A 5gs4A-4lt6A:
undetectable		 5gs4A-4lt6A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1805_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 7 VAL A 335
ILE A 440
SER A 329
THR A 332
 None
 0.96A 5vkqA-4lt6A:
undetectable
5vkqD-4lt6A:
undetectable		 5vkqA-4lt6A:
15.23
5vkqD-4lt6A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 5 MET A 312
TYR A 236
GLY A 244
GLY A 245
 None
None
3AT  A 601 ( 4.7A)
3AT  A 601 ( 3.8A)
 0.92A 5x7pA-4lt6A:
undetectable		 5x7pA-4lt6A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4lt6 POLY(A) POLYMERASE
GAMMA
(Homo
sapiens) 		4 / 6 MET A 312
TYR A 236
GLY A 244
GLY A 245
 None
None
3AT  A 601 ( 4.7A)
3AT  A 601 ( 3.8A)
 0.93A 5x7pB-4lt6A:
undetectable		 5x7pB-4lt6A:
17.43