SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lu0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 268
LEU A 271
LEU A 274
LEU A 242
THR A  51
 None
 1.41A 1a28B-4lu0A:
undetectable		 1a28B-4lu0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEH_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 203
ASN A 142
ILE A 117
GLU A 243
GLY A  30
 None
 1.25A 1mehA-4lu0A:
7.3		 1mehA-4lu0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MEI_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 203
ASN A 142
ILE A 117
GLY A  30
 None
 0.94A 1meiA-4lu0A:
12.1		 1meiA-4lu0A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_B_8MOB501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A 241
PHE A 201
ASN A 142
ILE A  99
ILE A  17
 None
 1.06A 1z11B-4lu0A:
undetectable		 1z11B-4lu0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 8 THR A  51
VAL A  50
ASN A 262
ALA A 244
 None
 1.09A 2ij7C-4lu0A:
undetectable		 2ij7C-4lu0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 174
ASP A 203
LYS A 144
LYS A  61
 None
 1.48A 3jqzA-4lu0A:
undetectable		 3jqzA-4lu0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 264
PRO A 246
GLN A  42
TYR A  47
 None
 1.27A 3vkxA-4lu0A:
undetectable		 3vkxA-4lu0A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A  87
GLY A  30
GLY A  29
TYR A  58
GLU A 243
 None
 1.34A 4fglA-4lu0A:
undetectable
4fglB-4lu0A:
undetectable		 4fglA-4lu0A:
24.43
4fglB-4lu0A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_B_CLQB303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lu0 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE
(Pseudomonas
aeruginosa) 		5 / 11 PHE A  87
ILE A  99
GLY A  30
GLY A  29
GLU A 243
 None
 1.20A 4fglA-4lu0A:
undetectable
4fglB-4lu0A:
undetectable		 4fglA-4lu0A:
24.43
4fglB-4lu0A:
24.43