SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lu6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 6 HIS A 406
LEU A 356
PHE A  84
VAL A 474
 None
 1.14A 1ibgH-4lu6A:
undetectable		 1ibgH-4lu6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 7 SER A 358
HIS A 170
SER A  77
LEU A 524
 None
 1.17A 1ibgL-4lu6A:
undetectable		 1ibgL-4lu6A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 12 LEU A 371
SER A 350
SER A 349
CYH A 227
HIS A 374
 None
 1.39A 1ie9A-4lu6A:
undetectable		 1ie9A-4lu6A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_B_BEZB1503_0
(RAS-RELATED PROTEIN
RAB-9A)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 6 VAL A 269
GLU A 522
LEU A 524
ARG A 525
 None
 1.10A 1s8fB-4lu6A:
1.6		 1s8fB-4lu6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
207L_A_SC2A200_1
(LYSOZYME)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 4 TRP A 126
HIS A 124
LEU A 122
CYH A 143
 None
 1.30A 207lA-4lu6A:
0.0		 207lA-4lu6A:
12.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		10 / 11 ILE A  52
PRO A  53
ILE A  82
HIS A 109
GLU A 357
TYR A 454
TYR A 455
PHE A 465
TRP A 466
ASN A 470
 None
 0.58A 2aqjA-4lu6A:
54.7		 2aqjA-4lu6A:
53.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 11 ILE A  52
PRO A  53
TYR A 455
PHE A 465
ASN A 467
 None
 1.36A 2aqjA-4lu6A:
54.7		 2aqjA-4lu6A:
53.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AQJ_A_TRPA650_0
(TRYPTOPHAN
HALOGENASE, PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		7 / 11 ILE A  82
HIS A 109
GLU A 357
TYR A 454
PHE A 465
TRP A 466
ASN A 470
 None
 1.28A 2aqjA-4lu6A:
54.7		 2aqjA-4lu6A:
53.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		9 / 10 ILE A  52
PRO A  53
ILE A  82
HIS A 109
TYR A 454
TYR A 455
PHE A 465
TRP A 466
ASN A 470
 None
 0.61A 2jkcA-4lu6A:
53.9		 2jkcA-4lu6A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 10 ILE A  52
PRO A  53
TYR A 455
PHE A 465
ASN A 467
 None
 1.38A 2jkcA-4lu6A:
53.9		 2jkcA-4lu6A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JKC_A_TRPA1520_0
(FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 10 ILE A  82
HIS A 109
TYR A 454
PHE A 465
TRP A 466
 None
 1.38A 2jkcA-4lu6A:
53.9		 2jkcA-4lu6A:
53.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		6 / 12 HIS A 109
GLU A 357
TYR A 455
PHE A 465
TRP A 466
ASN A 470
 None
 1.40A 2oa1A-4lu6A:
61.6		 2oa1A-4lu6A:
98.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2002_0
(TRYPTOPHAN
HALOGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		11 / 12 ILE A  52
PRO A  53
LYS A  79
ILE A  82
HIS A 109
PHE A 111
GLU A 357
TYR A 454
PHE A 465
TRP A 466
ASN A 470
 None
 0.37A 2oa1A-4lu6A:
61.6		 2oa1A-4lu6A:
98.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_A_TRPA2003_0
(TRYPTOPHAN
HALOGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		11 / 12 ILE A  52
PRO A  53
ILE A  82
HIS A 109
PHE A 111
GLU A 357
TYR A 454
TYR A 455
PHE A 465
TRP A 466
ASN A 470
 None
 0.43A 2oa1B-4lu6A:
62.2		 2oa1B-4lu6A:
98.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 7 GLY A  12
GLY A  13
ASP A  41
SER A 228
ARG A 231
 None
 0.80A 2oa1B-4lu6A:
62.2		 2oa1B-4lu6A:
98.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		6 / 7 GLY A  12
GLY A  13
ASP A  41
VAL A 197
SER A 228
LEU A 233
 None
 0.52A 2oa1B-4lu6A:
62.2		 2oa1B-4lu6A:
98.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 7 GLY A  17
PHE A  59
ILE A 361
PHE A  60
 None
 0.97A 2qmzA-4lu6A:
undetectable
2qmzB-4lu6A:
2.1		 2qmzA-4lu6A:
17.72
2qmzB-4lu6A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_1
(PROGESTERONE
RECEPTOR)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 12 LEU A 180
GLY A  25
GLN A  29
PHE A 179
VAL A 372
 None
 1.30A 2w8yA-4lu6A:
undetectable		 2w8yA-4lu6A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_B_ADNB438_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		3 / 3 THR A 348
GLU A  49
HIS A 174
 PO4  A 601 (-3.4A)
None
None
 0.70A 3g1uB-4lu6A:
2.6		 3g1uB-4lu6A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_B_478B200_2
(HIV-1 PROTEASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 10 ALA A  32
ASP A   6
VAL A 372
VAL A 225
ILE A   8
 None
 1.00A 3oxvB-4lu6A:
undetectable		 3oxvB-4lu6A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 11 ALA A  32
ASP A   6
VAL A 372
VAL A 225
ILE A   8
 None
 1.02A 3oxvD-4lu6A:
undetectable		 3oxvD-4lu6A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 5 ARG A 400
LEU A 250
VAL A 353
ASP A 401
 None
 1.14A 3ufnA-4lu6A:
undetectable
3ufnB-4lu6A:
undetectable		 3ufnA-4lu6A:
12.32
3ufnB-4lu6A:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		3 / 3 ASP A 195
ARG A 231
THR A 215
 None
 0.83A 4i13A-4lu6A:
undetectable		 4i13A-4lu6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 4 ASP A 195
LEU A  37
ARG A 231
THR A 215
 None
 1.22A 4kjjA-4lu6A:
undetectable		 4kjjA-4lu6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 4 ASP A 195
LEU A  37
ARG A 231
THR A 215
 None
 1.19A 4kjkA-4lu6A:
undetectable		 4kjkA-4lu6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		3 / 3 ASP A 195
ARG A 231
THR A 215
 None
 0.85A 4p3rA-4lu6A:
undetectable		 4p3rA-4lu6A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		5 / 12 PHE A 224
LEU A 223
GLY A  12
LEU A  37
VAL A 197
 None
 1.09A 4wnwA-4lu6A:
undetectable		 4wnwA-4lu6A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 6 GLY A 461
GLU A 460
PHE A 458
TYR A 455
 None
 0.93A 5kmfA-4lu6A:
undetectable
5kmfC-4lu6A:
undetectable		 5kmfA-4lu6A:
20.18
5kmfC-4lu6A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 7 ILE A 346
PHE A 462
THR A 394
ARG A 387
 None
 1.01A 5vc0A-4lu6A:
undetectable		 5vc0A-4lu6A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 5 PHE A 292
GLU A 270
ASP A 264
HIS A 262
 None
 1.41A 6b58C-4lu6A:
9.7		 6b58C-4lu6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_1
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 4lu6 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE REBH
(Lechevalieria
aerocolonigenes) 		4 / 6 SER A 166
GLN A 452
GLU A  67
THR A  51
 None
 1.18A 6djzA-4lu6A:
undetectable		 6djzA-4lu6A:
18.03