SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 11 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.94A 1dhiB-4lubA:
undetectable		 1dhiB-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 1.00A 1dhjB-4lubA:
undetectable		 1dhjB-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 1.00A 1draA-4lubA:
undetectable		 1draA-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.91A 1draB-4lubA:
undetectable		 1draB-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.98A 1drbA-4lubA:
undetectable		 1drbA-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.91A 1drbB-4lubA:
undetectable		 1drbB-4lubA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
ALA A 200
LEU A 261
ARG A 221
ILE A 197
 None
 1.03A 2drcA-4lubA:
undetectable		 2drcA-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 1.02A 2drcA-4lubA:
undetectable		 2drcA-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.95A 2drcB-4lubA:
undetectable		 2drcB-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 5 LEU A  71
ALA A 200
ILE A 243
SER A 198
 None
 0.87A 2othA-4lubA:
undetectable		 2othA-4lubA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 1.01A 3drcA-4lubA:
undetectable		 3drcA-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.93A 3drcB-4lubA:
undetectable		 3drcB-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 270
LEU A 261
ILE A 223
ARG A 221
ILE A 197
 None
 0.95A 4dfrB-4lubA:
undetectable		 4dfrB-4lubA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 12 ILE A 223
LEU A 201
PHE A 246
ILE A 270
VAL A 254
 None
 1.01A 4kfjB-4lubA:
undetectable		 4kfjB-4lubA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 8 GLY A  12
LEU A  32
TYR A  10
PHE A  34
 None
 1.19A 4m5mA-4lubA:
4.2		 4m5mA-4lubA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		4 / 5 TYR A 277
LEU A  85
GLU A  82
VAL A  64
 None
 1.33A 4nkvA-4lubA:
undetectable		 4nkvA-4lubA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		3 / 3 PHE A  68
ARG A 177
ALA A  79
 None
 0.99A 6ecfB-4lubA:
undetectable		 6ecfB-4lubA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FTP_B_DM2B501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 4lub PUTATIVE PREPHENATE
DEHYDRATASE
(Streptococcus
mutans) 		5 / 9 LEU A 199
SER A 198
PHE A 246
LEU A 225
VAL A 254
 None
 1.12A 6ftpA-4lubA:
undetectable
6ftpB-4lubA:
undetectable		 6ftpA-4lubA:
16.67
6ftpB-4lubA:
10.61