SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4luj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_A_FLPA1650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.03A 1cqeA-4lujA:
undetectable		 1cqeA-4lujA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQE_B_FLPB2650_1
(PROTEIN
(PROSTAGLANDIN H2
SYNTHASE-1))		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.03A 1cqeB-4lujA:
undetectable		 1cqeB-4lujA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 10 GLY A 107
LEU A 157
VAL A 159
ALA A  83
ASN A  89
 None
 1.27A 1fpqA-4lujA:
undetectable		 1fpqA-4lujA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ALA A 213
TYR A 215
ILE A 214
ASP A  29
 None
None
None
BMP  A 301 (-2.9A)
 1.25A 1upfA-4lujA:
undetectable		 1upfA-4lujA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		6 / 12 THR A  62
ILE A  77
GLY A 102
ILE A  65
VAL A 128
ALA A  93
 None
 1.44A 1vq1B-4lujA:
undetectable		 1vq1B-4lujA:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_B_FLPB2701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.07A 2aylB-4lujA:
undetectable		 2aylB-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  24
TYR A 227
ILE A 214
GLY A 187
 None
 0.88A 2du8A-4lujA:
undetectable		 2du8A-4lujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  24
TYR A 227
ILE A 214
GLY A 187
 None
 0.91A 2du8B-4lujA:
undetectable		 2du8B-4lujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 VAL A  47
VAL A 208
TYR A 227
VAL A  43
 None
 0.82A 3fhxB-4lujA:
undetectable		 3fhxB-4lujA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.00A 3kk6A-4lujA:
undetectable		 3kk6A-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.05A 3n8zB-4lujA:
undetectable		 3n8zB-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 209
LYS A  69
LYS A 126
GLY A 102
 BMP  A 301 ( 4.4A)
None
None
None
 1.16A 3sj0X-4lujA:
undetectable		 3sj0X-4lujA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		4 / 5 ARG A 171
THR A 132
PRO A 165
VAL A 183
 None
 1.19A 4mjqA-4lujA:
undetectable		 4mjqA-4lujA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  96
ALA A  78
LYS A  51
 None
None
BMP  A 301 (-2.8A)
 0.57A 6fgcA-4lujA:
undetectable		 6fgcA-4lujA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A  96
ALA A  78
LYS A  51
 None
None
BMP  A 301 (-2.8A)
 0.54A 6fgdA-4lujA:
undetectable		 6fgdA-4lujA:
19.71