SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lun'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 PHE U  40
LEU U  57
ILE U  97
VAL U  76
ILE U  72
 None
 1.40A 1gebA-4lunU:
undetectable		 1gebA-4lunU:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OAF_A_ASCA1253_0
(ASCORBATE PEROXIDASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 6 LYS U 293
PRO U 287
LEU U 286
HIS U 315
 None
 1.42A 1oafA-4lunU:
undetectable		 1oafA-4lunU:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.28A 1odiA-4lunU:
undetectable		 1odiA-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.30A 1odiB-4lunU:
undetectable		 1odiB-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.36A 1odiC-4lunU:
undetectable		 1odiC-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_D_ADND1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.24A 1odiD-4lunU:
undetectable		 1odiD-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.33A 1odiE-4lunU:
undetectable		 1odiE-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 11 ARG U 136
GLY U 198
GLU U 130
GLU U 133
ILE U 288
 None
 1.24A 1odiF-4lunU:
undetectable		 1odiF-4lunU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 9 PHE U  40
LEU U  57
GLY U  99
VAL U  76
ILE U  72
 None
 1.32A 2a1oB-4lunU:
undetectable		 2a1oB-4lunU:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 5 ARG U 139
PHE U 147
PHE U 116
LEU U  81
 None
 1.39A 3abmC-4lunU:
2.5
3abmJ-4lunU:
undetectable		 3abmC-4lunU:
20.43
3abmJ-4lunU:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 SER U 185
LEU U 231
PHE U 147
LEU U 113
LEU U 172
 None
CL  U 401 ( 3.9A)
None
None
None
 1.35A 4o8fB-4lunU:
undetectable		 4o8fB-4lunU:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA503_1
(PENTALENIC ACID
SYNTHASE)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 LEU U 112
ALA U  93
LEU U 150
ILE U  96
 None
 0.86A 4ubsA-4lunU:
undetectable		 4ubsA-4lunU:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		4 / 7 ILE U 290
HIS U 254
LEU U 253
ALA U 250
 None
 1.00A 5hrqE-4lunU:
undetectable
5hrqF-4lunU:
undetectable
5hrqJ-4lunU:
undetectable		 5hrqE-4lunU:
7.83
5hrqF-4lunU:
7.69
5hrqJ-4lunU:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		3 / 3 ARG U 139
PHE U 147
LEU U  81
 None
 0.68A 5x1bC-4lunU:
2.4		 5x1bC-4lunU:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 4lun NONSENSE-MEDIATED
MRNA DECAY PROTEIN 2
(Saccharomyces
cerevisiae) 		5 / 12 PHE U 104
ILE U  72
ARG U 103
LEU U 100
ALA U  63
 None
 1.37A 5zwrB-4lunU:
undetectable		 5zwrB-4lunU:
22.65