SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lut'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 7 HIS A  45
GLY A  44
ALA A  42
TYR A  43
 None
None
None
DCS  A 401 (-4.6A)
 0.90A 1dmaA-4lutA:
undetectable		 1dmaA-4lutA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 12 ALA A  42
ARG A  18
SER A 208
ILE A 227
LEU A 244
 None
None
DCS  A 401 (-2.3A)
None
None
 0.98A 1drfA-4lutA:
undetectable		 1drfA-4lutA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 6 ALA A 344
GLU A 345
TYR A 356
ILE A 354
LEU A 359
 None
None
DCS  A 401 (-4.0A)
None
None
 1.29A 1xvaA-4lutA:
undetectable
1xvaB-4lutA:
undetectable		 1xvaA-4lutA:
20.49
1xvaB-4lutA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 12 ARG A 223
ILE A  24
LEU A 228
GLY A 230
ALA A 224
 DCS  A 401 (-4.1A)
None
None
None
None
 0.96A 2oc8A-4lutA:
undetectable		 2oc8A-4lutA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		3 / 3 SER A 252
ASP A 367
ASP A 289
 None
 0.73A 2plwA-4lutA:
undetectable		 2plwA-4lutA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 7 TYR A 229
TYR A 370
LEU A  17
ASN A  20
 None
 1.47A 2w98A-4lutA:
2.2
2w98B-4lutA:
2.1		 2w98A-4lutA:
22.71
2w98B-4lutA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 6 TYR A 356
MET A 212
ILE A  24
LEU A 244
 DCS  A 401 (-4.0A)
None
None
None
 1.31A 2wekB-4lutA:
undetectable		 2wekB-4lutA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_B_IMNB3_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 12 ALA A 111
ILE A 159
LEU A 161
VAL A 198
ILE A 151
 None
 1.32A 3adsB-4lutA:
undetectable		 3adsB-4lutA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 12 GLY A 225
LEU A  17
VAL A  50
ILE A  38
LEU A 242
 DCS  A 401 (-3.3A)
None
None
None
None
 1.29A 3g9eA-4lutA:
undetectable		 3g9eA-4lutA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 9 TYR A 356
ASN A 355
ILE A 354
ASP A 236
GLU A 345
 DCS  A 401 (-4.0A)
None
None
None
None
 0.94A 3rukC-4lutA:
undetectable		 3rukC-4lutA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3O_B_T1CB405_1
(TETX2 PROTEIN)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 12 ASN A  13
GLY A 230
ALA A  47
GLY A  46
GLU A  72
 None
 1.30A 3v3oB-4lutA:
undetectable		 3v3oB-4lutA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V5W_A_8PRA701_2
(G-PROTEIN COUPLED
RECEPTOR KINASE 2)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		3 / 3 LEU A 359
MET A 361
ASP A 289
 None
 0.90A 3v5wA-4lutA:
undetectable		 3v5wA-4lutA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WCX_C_SAMC503_1
(BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 6 CYH A 360
LEU A  73
GLU A  69
TYR A  43
 None
None
None
DCS  A 401 (-4.6A)
 1.48A 4wcxC-4lutA:
8.7		 4wcxC-4lutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 8 ILE A 211
LEU A  27
ILE A 227
LEU A 242
 None
 0.83A 4zvcA-4lutA:
undetectable
4zvcB-4lutA:
undetectable		 4zvcA-4lutA:
17.20
4zvcB-4lutA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 8 ILE A 227
LEU A 242
ILE A 211
LEU A  27
 None
 0.83A 4zvcA-4lutA:
undetectable
4zvcB-4lutA:
undetectable		 4zvcA-4lutA:
17.20
4zvcB-4lutA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 4 LEU A 228
ILE A 227
GLY A  36
ILE A 211
 None
 0.87A 5dzk3-4lutA:
undetectable
5dzkm-4lutA:
undetectable		 5dzk3-4lutA:
7.14
5dzkm-4lutA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		4 / 5 ILE A 227
GLY A  36
ILE A 211
LEU A 228
 None
 0.90A 5dzkd-4lutA:
undetectable
5dzkk-4lutA:
undetectable
5dzky-4lutA:
undetectable		 5dzkd-4lutA:
22.36
5dzkk-4lutA:
22.22
5dzky-4lutA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 10 GLY A 163
LEU A 161
GLN A 141
PHE A 140
LEU A 193
 None
 1.14A 5fhzC-4lutA:
undetectable		 5fhzC-4lutA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		3 / 3 THR A 343
HIS A 231
ASN A 355
 None
 1.01A 5n4tA-4lutA:
2.1		 5n4tA-4lutA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA503_1
(-)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 9 LEU A  21
VAL A  50
LEU A  54
LEU A 244
ALA A  42
 None
 1.22A 5og9A-4lutA:
undetectable		 5og9A-4lutA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		5 / 10 SER A  96
ARG A  66
GLY A  70
ILE A 211
LEU A  28
 None
 1.27A 5oy01-4lutA:
undetectable
5oy07-4lutA:
undetectable		 5oy01-4lutA:
12.80
5oy07-4lutA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 4lut ALANINE RACEMASE
(Clostridioides
difficile) 		3 / 3 LYS A 299
VAL A 306
ASP A 308
 None
 0.63A 6fgdA-4lutA:
undetectable		 6fgdA-4lutA:
22.27