SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lvn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC2_0
(ACTINOMYCIN D)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR C 124
PRO C 154
THR C 123
PRO C 125
 None
 1.28A 1dsdC-4lvnC:
undetectable		 1dsdC-4lvnC:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSD_C_DVAC8_0
(ACTINOMYCIN D)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 4 THR C 124
PRO C 154
THR C 123
PRO C 125
 None
 1.28A 1dsdC-4lvnC:
undetectable		 1dsdC-4lvnC:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 6 SER C  28
GLY C  56
THR C  74
ILE C  52
 None
 0.84A 1gtnD-4lvnC:
undetectable
1gtnE-4lvnC:
undetectable		 1gtnD-4lvnC:
15.28
1gtnE-4lvnC:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		5 / 10 VAL C 170
VAL C 188
SER C 186
ASN C 203
ASN C 162
 None
 1.47A 4ldoA-4lvnC:
undetectable		 4ldoA-4lvnC:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 ARG C  67
VAL C  86
ASP C  89
ASP C  90
 None
 0.97A 4xqgA-4lvnC:
undetectable		 4xqgA-4lvnC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 8 ARG C  67
VAL C  86
ASP C  89
ASP C  90
 None
 0.97A 4xqgB-4lvnC:
undetectable		 4xqgB-4lvnC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 4lvn NIMP.M7 FAB HEAVY
CHAIN
(Mus
musculus) 		4 / 5 GLU C 155
PHE C 153
HIS C 206
THR C 117
 None
 1.20A 6b58A-4lvnC:
undetectable		 6b58A-4lvnC:
16.32