SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 10 GLY A 440
VAL A 451
GLY A 448
ASN A 441
HIS A 334
 CA  A 701 ( 4.4A)
None
None
None
None
 1.26A 1v3qE-4lvoA:
undetectable		 1v3qE-4lvoA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 4 HIS A 428
ASP A 425
ASN A 421
ASP A 372
 None
 1.46A 1wg8A-4lvoA:
2.3		 1wg8A-4lvoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WG8_A_SAMA3142_1
(PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 4 HIS A 428
ASP A 462
ASN A 417
ASP A 372
 None
 1.39A 1wg8A-4lvoA:
2.3		 1wg8A-4lvoA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTF_A_2TNA201_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 LEU A 618
SER A 437
GLY A 448
HIS A 611
 None
 0.95A 2otfA-4lvoA:
undetectable		 2otfA-4lvoA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 ILE A 545
LEU A 546
PRO A 610
THR A 605
VAL A 553
 None
 1.07A 3dcjA-4lvoA:
2.9
3dcjB-4lvoA:
2.9		 3dcjA-4lvoA:
18.36
3dcjB-4lvoA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA279_0
(UNIVERSAL STRESS
PROTEIN)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 4 SER A 492
SER A 606
THR A 605
SER A 517
 None
 1.45A 3loqA-4lvoA:
undetectable		 3loqA-4lvoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 ASN A 488
ALA A 609
PRO A 610
ALA A 614
 None
 1.28A 3twpD-4lvoA:
3.0		 3twpD-4lvoA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		3 / 3 ASN A 404
ASP A 409
ASN A 389
 CA  A 703 (-2.8A)
CA  A 703 (-2.8A)
None
 0.80A 4agaA-4lvoA:
undetectable		 4agaA-4lvoA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 8 VAL A 449
ILE A 657
SER A 617
ALA A 664
 None
 0.88A 4eyzA-4lvoA:
undetectable		 4eyzA-4lvoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 8 VAL A 449
ILE A 657
SER A 617
ALA A 664
 None
 0.88A 4eyzB-4lvoA:
undetectable		 4eyzB-4lvoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 VAL A 504
ALA A 413
PHE A 415
LEU A 469
VAL P 214
 None
 1.26A 4ib4A-4lvoA:
undetectable		 4ib4A-4lvoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 TYR A 542
PRO A 543
ASN A 501
ILE P 178
PHE A 514
 None
 1.38A 4kovA-4lvoA:
undetectable		 4kovA-4lvoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O4D_A_ACTA406_0
(INOSITOL
HEXAKISPHOSPHATE
KINASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 7 ASP A 376
THR A 430
SER A 598
HIS A 379
 None
 1.36A 4o4dA-4lvoA:
undetectable		 4o4dA-4lvoA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		3 / 3 SER A 621
ASP A 450
GLN A 355
 None
 0.95A 4oltA-4lvoA:
undetectable
4oltB-4lvoA:
undetectable		 4oltA-4lvoA:
20.55
4oltB-4lvoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		3 / 3 GLN A 355
SER A 621
ASP A 450
 None
 0.88A 4qwpA-4lvoA:
undetectable
4qwpB-4lvoA:
0.8		 4qwpA-4lvoA:
20.55
4qwpB-4lvoA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		3 / 3 MET A 486
GLN A 508
TYR A 550
 None
 1.07A 4udcA-4lvoA:
undetectable		 4udcA-4lvoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 GLY A 434
GLY A 448
ILE A 375
LYS A 383
LEU A 382
 None
 1.25A 5bw4B-4lvoA:
2.1		 5bw4B-4lvoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 THR A 593
ALA A 594
THR A 430
HIS A 379
 None
 1.18A 5ecmA-4lvoA:
undetectable		 5ecmA-4lvoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 LEU A 570
GLY A 345
ASP A 347
LEU A 645
ALA A 584
 None
 1.07A 5h5fA-4lvoA:
undetectable		 5h5fA-4lvoA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 HIS A 611
VAL A 446
GLY A 434
ALA A 438
 None
 1.06A 5hwaA-4lvoA:
undetectable		 5hwaA-4lvoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_A_FUAA1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 ILE A 435
LYS A 454
ILE A 368
VAL A 370
 None
 1.01A 5jmnA-4lvoA:
undetectable		 5jmnA-4lvoA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		5 / 12 GLU P 209
ASP P 211
GLY A 470
MET A 472
LEU A 476
 None
 1.42A 5kbwA-4lvoP:
undetectable		 5kbwA-4lvoP:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		3 / 3 THR A 605
SER A 517
ASP A 372
 None
 0.74A 5kvaA-4lvoA:
undetectable		 5kvaA-4lvoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		5 / 9 PRO A 586
MET A 607
LEU A 570
SER A 574
ASP P 217
 None
 1.24A 6dm2A-4lvoA:
7.1
6dm2D-4lvoA:
6.5		 6dm2A-4lvoA:
20.64
6dm2D-4lvoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		5 / 9 PRO A 586
MET A 607
LEU A 570
SER A 574
ASP P 217
 None
 1.24A 6dm2B-4lvoA:
7.0
6dm2C-4lvoA:
6.9		 6dm2B-4lvoA:
20.64
6dm2C-4lvoA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 6 TYR A 580
VAL A 553
VAL A 549
THR A 548
 None
 1.33A 6f32B-4lvoA:
undetectable		 6f32B-4lvoA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum) 		4 / 5 GLY A 604
THR A 605
HIS A 428
SER A 490
 None
 1.15A 6jmjA-4lvoA:
undetectable		 6jmjA-4lvoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 5 GLY A 604
THR A 605
HIS A 428
SER P 215
 None
 0.98A 6jmjA-4lvoA:
undetectable		 6jmjA-4lvoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lvo SUBTILISIN-LIKE
SERINE PROTEASE
SUBTILISIN-LIKE
SERINE PROTEASE
(Plasmodium
falciparum;
Plasmodium
falciparum) 		4 / 6 GLY A 604
THR A 605
HIS A 428
SER P 215
 None
 1.00A 6jogA-4lvoA:
undetectable		 6jogA-4lvoA:
20.71