SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lvq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EII_A_RTLA135_1
(CELLULAR
RETINOL-BINDING
PROTEIN II)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 7 GLN A  59
THR A 314
TYR A 315
GLN A 343
 None
 1.41A 1eiiA-4lvqA:
undetectable		 1eiiA-4lvqA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 122
VAL A 293
VAL A 288
GLY A 287
LEU A 107
 None
 1.06A 1fkpA-4lvqA:
undetectable		 1fkpA-4lvqA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 122
VAL A 293
VAL A 288
GLY A 287
LEU A 107
 None
 1.18A 1lwcA-4lvqA:
undetectable		 1lwcA-4lvqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 315
LEU A 312
ASN A 196
LYS A 215
 None
 1.36A 2w98A-4lvqA:
undetectable
2w98B-4lvqA:
undetectable		 2w98A-4lvqA:
22.77
2w98B-4lvqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9W_A_ACTA170_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		3 / 3 SER A 191
GLY A 192
THR A 193
 PO4  A 401 (-2.6A)
PO4  A 401 (-3.4A)
PO4  A 401 (-4.2A)
 0.13A 3k9wA-4lvqA:
undetectable		 3k9wA-4lvqA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 8 GLY A  87
PHE A 334
GLY A 101
PHE A 100
 None
 0.97A 3ko0O-4lvqA:
undetectable
3ko0Q-4lvqA:
undetectable		 3ko0O-4lvqA:
17.16
3ko0Q-4lvqA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 312
ALA A  58
SER A  56
SER A  86
 None
PO4  A 401 (-3.2A)
PO4  A 401 (-3.8A)
PO4  A 401 (-2.7A)
 1.06A 3rodA-4lvqA:
undetectable		 3rodA-4lvqA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJE_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		5 / 12 ASN A 125
GLY A  89
SER A  86
GLN A  59
ILE A  90
 None
None
PO4  A 401 (-2.7A)
None
None
 1.39A 4djeA-4lvqA:
undetectable		 4djeA-4lvqA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 5 ALA A  58
GLY A 131
ASP A 291
ASP A 104
 PO4  A 401 (-3.2A)
None
None
PO4  A 401 (-3.1A)
 1.00A 4n48A-4lvqA:
undetectable		 4n48A-4lvqA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 6 LEU A  51
PHE A 334
THR A 338
VAL A 128
 None
 0.93A 4udaA-4lvqA:
undetectable		 4udaA-4lvqA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  79
ALA A 333
VAL A 128
ILE A 339
 None
 0.91A 4xe3A-4lvqA:
undetectable		 4xe3A-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  79
THR A 364
VAL A 128
ILE A 339
 None
 0.95A 4xe3A-4lvqA:
undetectable		 4xe3A-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  79
ALA A 333
VAL A 128
ILE A 339
 None
 0.95A 4xe3B-4lvqA:
undetectable		 4xe3B-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 5 LEU A  79
THR A 364
VAL A 128
ILE A 339
 None
 0.82A 4xe3B-4lvqA:
undetectable		 4xe3B-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 122
VAL A 293
VAL A 288
GLY A 287
LEU A 107
 None
 1.21A 5hbmA-4lvqA:
undetectable		 5hbmA-4lvqA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		5 / 12 THR A  57
GLY A 192
THR A 314
SER A 216
GLU A 190
 PO4  A 401 (-2.8A)
PO4  A 401 (-3.4A)
None
None
None
 1.40A 5hfjG-4lvqA:
undetectable		 5hfjG-4lvqA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 7 ALA A  83
GLY A  85
GLY A  89
ASN A  61
 None
PO4  A 401 (-3.4A)
None
None
 0.72A 5ybbB-4lvqA:
undetectable		 5ybbB-4lvqA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3
(Mycobacterium
tuberculosis) 		4 / 7 ARG A 181
GLU A 180
TRP A 163
PRO A 239
 None
 1.44A 6a4iB-4lvqA:
undetectable		 6a4iB-4lvqA:
20.14