SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lw6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		5 / 12 ILE A 186
ILE A 231
ASN A 152
ASN A 154
LEU A 101
 None
 1.11A 1fm4A-4lw6A:
undetectable		 1fm4A-4lw6A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		4 / 6 ILE A 186
MET A  97
THR A  98
LEU A 101
 None
 1.01A 3ag1N-4lw6A:
undetectable
3ag1W-4lw6A:
undetectable		 3ag1N-4lw6A:
18.40
3ag1W-4lw6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		5 / 12 TYR A 177
GLY A 206
GLU A 210
GLY A 208
HIS A 243
 XYP  A 403 ( 3.4A)
None
SEL  A 405 (-3.1A)
SEL  A 405 ( 3.1A)
MN  A 401 ( 3.3A)
 1.01A 3f8wA-4lw6A:
undetectable		 3f8wA-4lw6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		5 / 12 TYR A 177
GLY A 206
GLU A 210
GLY A 208
HIS A 243
 XYP  A 403 ( 3.4A)
None
SEL  A 405 (-3.1A)
SEL  A 405 ( 3.1A)
MN  A 401 ( 3.3A)
 1.00A 3f8wB-4lw6A:
undetectable		 3f8wB-4lw6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		3 / 3 LEU A  79
HIS A 108
MET A  77
 None
 0.96A 3thrD-4lw6A:
undetectable		 3thrD-4lw6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_0
(TUBULIN BETA-2B
CHAIN)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		5 / 11 GLN A 203
VAL A 274
ASP A 272
TYR A 276
LEU A 298
 None
 1.42A 5jh7B-4lw6A:
undetectable		 5jh7B-4lw6A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		4 / 8 SER A 125
THR A 269
SER A 201
THR A 305
 None
 1.03A 5l4eA-4lw6A:
undetectable
5l4eB-4lw6A:
undetectable
5l4eC-4lw6A:
undetectable
5l4eD-4lw6A:
undetectable
5l4eE-4lw6A:
undetectable		 5l4eA-4lw6A:
21.41
5l4eB-4lw6A:
21.41
5l4eC-4lw6A:
21.41
5l4eD-4lw6A:
21.41
5l4eE-4lw6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		4 / 8 THR A 305
SER A 125
THR A 269
SER A 201
 None
 1.01A 5l4eA-4lw6A:
undetectable
5l4eB-4lw6A:
undetectable
5l4eC-4lw6A:
undetectable
5l4eD-4lw6A:
undetectable
5l4eE-4lw6A:
undetectable		 5l4eA-4lw6A:
21.41
5l4eB-4lw6A:
21.41
5l4eC-4lw6A:
21.41
5l4eD-4lw6A:
21.41
5l4eE-4lw6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		4 / 7 ILE A 186
MET A  97
THR A  98
LEU A 101
 None
 0.98A 6nmfA-4lw6A:
undetectable
6nmfJ-4lw6A:
undetectable		 6nmfA-4lw6A:
18.40
6nmfJ-4lw6A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lw6 BETA-4-GALACTOSYLTRA
NSFERASE 7
(Drosophila
melanogaster) 		4 / 7 ILE A 186
MET A  97
THR A  98
LEU A 101
 None
 0.92A 6nmpA-4lw6A:
undetectable
6nmpJ-4lw6A:
undetectable		 6nmpA-4lw6A:
18.40
6nmpJ-4lw6A:
13.36