SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lw8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_C_115C4_2
(HMG-COA REDUCTASE)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 8 HIS A  83
LEU A 109
ALA A 112
LEU A 113
 None
 0.67A 1hwiD-4lw8A:
undetectable		 1hwiD-4lw8A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A 290
GLU A 237
PRO A 234
ALA A 232
 None
EPE  A 400 (-2.9A)
None
None
 1.37A 2ejfB-4lw8A:
undetectable		 2ejfB-4lw8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 7 ARG A 290
GLU A 237
PRO A 234
ALA A 232
 None
EPE  A 400 (-2.9A)
None
None
 1.28A 2ejgA-4lw8A:
undetectable		 2ejgA-4lw8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A 124
LEU A 125
LEU A  84
LEU A 227
MET A  26
 None
 1.31A 3d90B-4lw8A:
undetectable		 3d90B-4lw8A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A  77
ARG A   8
ASP A  36
ARG A  12
 None
 1.23A 4kcnA-4lw8A:
undetectable		 4kcnA-4lw8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 6 ARG A  77
ARG A   8
ASP A  36
ARG A  12
 None
 1.23A 4kcnB-4lw8A:
undetectable		 4kcnB-4lw8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 4 ASN A 150
SER A 128
ALA A 153
VAL A 154
 None
 1.24A 4x1kC-4lw8A:
6.2		 4x1kC-4lw8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		4 / 8 GLY A  39
ARG A   8
ASP A  36
ASP A  75
 None
 0.66A 5vlmB-4lw8A:
undetectable		 5vlmB-4lw8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		5 / 12 LEU A  84
GLY A  17
VAL A 219
TYR A 180
ALA A  52
 None
 0.98A 5xv7A-4lw8A:
undetectable		 5xv7A-4lw8A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4lw8 PUTATIVE EPIMERASE
(Burkholderia
cenocepacia) 		5 / 12 VAL A 263
ILE A 205
LEU A 249
PHE A 272
LEU A 194
 None
 1.19A 6ajiA-4lw8A:
undetectable		 6ajiA-4lw8A:
17.33