SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lwo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.82A 1iepA-4lwoB:
undetectable		 1iepA-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 SER B 141
LEU B 131
HIS B 127
VAL B  59
ILE B 115
 None
 1.43A 1uobA-4lwoB:
undetectable		 1uobA-4lwoB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY B  62
GLY B  64
ALA B  85
THR B 111
GLU B 113
 None
 0.71A 2gluA-4lwoB:
9.0		 2gluA-4lwoB:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 LEU B 345
LEU B 245
MET B 349
THR B 192
 None
 1.31A 2oaxD-4lwoB:
undetectable		 2oaxD-4lwoB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1161_1
(ALLERGEN ARG R 1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 VAL B 112
VAL B  59
ASP B  60
SER B 141
 None
 1.10A 2x45A-4lwoB:
undetectable		 2x45A-4lwoB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.78A 3ms9A-4lwoB:
undetectable		 3ms9A-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.79A 3mssA-4lwoB:
undetectable		 3mssA-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.77A 3mssB-4lwoB:
undetectable		 3mssB-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.78A 3mssC-4lwoB:
undetectable		 3mssC-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 VAL B  57
VAL B  61
ILE B 177
MET B 153
 None
 0.76A 3mssD-4lwoB:
undetectable		 3mssD-4lwoB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 LEU B 271
SER B 274
LEU B 241
PRO B 190
 None
 1.26A 3onnA-4lwoB:
undetectable		 3onnA-4lwoB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY B  64
THR B  65
GLU B  84
ASP B  60
 None
 0.94A 3ps9A-4lwoB:
5.6		 3ps9A-4lwoB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 VAL B 232
PHE B 146
PHE B 149
VAL B 186
 None
 1.36A 3rv5C-4lwoB:
undetectable
3rv5D-4lwoB:
undetectable		 3rv5C-4lwoB:
14.69
3rv5D-4lwoB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 6 GLY B  64
GLU B  84
ASP B  60
GLU B 113
 None
 0.98A 3vywC-4lwoB:
5.5		 3vywC-4lwoB:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ILE B  83
MET B 153
ARG B 359
 None
 0.78A 4lnwA-4lwoB:
undetectable		 4lnwA-4lwoB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		3 / 3 ILE B  83
MET B 153
ARG B 359
 None
 0.81A 4lnxA-4lwoB:
undetectable		 4lnxA-4lwoB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN B 321
THR B 296
HIS B 280
LEU B 238
 None
 1.40A 4lvcA-4lwoB:
3.1		 4lvcA-4lwoB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN B 321
THR B 323
HIS B 280
LEU B 238
 None
 1.34A 4lvcA-4lwoB:
3.1		 4lvcA-4lwoB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN B 321
THR B 323
HIS B 280
LEU B 238
 None
 1.34A 4lvcC-4lwoB:
2.9		 4lvcC-4lwoB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 7 ASN B 162
ARG B 161
GLN B 256
VAL B 255
 None
 1.06A 4mv7A-4lwoB:
3.4		 4mv7A-4lwoB:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X61_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY B  62
GLY B  64
LEU B  68
ARG B 359
GLU B 142
 None
 1.01A 4x61A-4lwoB:
17.3		 4x61A-4lwoB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_G_SAMG301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 12 GLY B  62
GLY B  64
LEU B  68
ALA B  85
GLU B 113
 None
 0.86A 5c0oG-4lwoB:
8.4		 5c0oG-4lwoB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 8 PRO B 312
LYS B 320
THR B 323
THR B 296
 None
 1.15A 5x2sI-4lwoB:
undetectable
5x2sJ-4lwoB:
undetectable
5x2sK-4lwoB:
undetectable		 5x2sI-4lwoB:
17.22
5x2sJ-4lwoB:
18.21
5x2sK-4lwoB:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		5 / 9 LEU B 247
VAL B 186
VAL B 188
ILE B 324
ILE B 363
 None
 0.97A 5yf9X-4lwoB:
undetectable		 5yf9X-4lwoB:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_B_ADNB505_2
(-)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 4 GLN B 321
THR B 296
HIS B 280
LEU B 238
 None
 1.43A 6f3nB-4lwoB:
3.6		 6f3nB-4lwoB:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN B 321
THR B 323
HIS B 280
LEU B 238
 None
 1.30A 6gbnA-4lwoB:
3.3		 6gbnA-4lwoB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE
(Trypanosoma
brucei) 		4 / 5 GLN B 321
THR B 323
HIS B 280
LEU B 238
 None
 1.33A 6gbnD-4lwoB:
3.2		 6gbnD-4lwoB:
21.18