SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lws'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		5 / 12 LEU B  33
LEU B  30
LEU B  27
MET B  66
MET A  29
 None
 1.48A 1sqnA-4lwsB:
undetectable		 1sqnA-4lwsB:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4lws UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata) 		3 / 3 GLY B  10
GLU B  14
ASN B   8
 None
 0.64A 1zq9A-4lwsB:
undetectable		 1zq9A-4lwsB:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4lws UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata) 		3 / 3 GLU A  88
GLN A  93
ARG A  97
 None
 0.94A 2w3bB-4lwsA:
undetectable		 2w3bB-4lwsA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4lws UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata) 		5 / 9 THR A  80
LEU A  77
ALA B  48
LEU B  41
TYR B  55
 None
None
None
None
ACT  B 103 ( 4.9A)
 1.25A 4ltwA-4lwsA:
undetectable		 4ltwA-4lwsA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.25A 4w5qA-4lwsB:
undetectable		 4w5qA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.26A 4w5rA-4lwsB:
undetectable		 4w5rA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.27A 4w5tA-4lwsB:
undetectable		 4w5tA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.27A 4z4cA-4lwsB:
undetectable		 4z4cA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.25A 4z4fA-4lwsB:
undetectable		 4z4fA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 5 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.28A 4z4gA-4lwsB:
undetectable		 4z4gA-4lwsB:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4lws UNCHARACTERIZED
PROTEIN
UNCHARACTERIZED
PROTEIN
(Thermomonospora
curvata;
Thermomonospora
curvata) 		4 / 6 ASP B  45
THR A  80
THR A  83
TYR A  84
 None
 1.30A 4z4iA-4lwsB:
undetectable		 4z4iA-4lwsB:
8.90