SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lx3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
NUCLEIC ACID
BINDING, OB-FOLD,
TRNA/HELICASE-TYPE
(Nostoc
punctiforme;
Nostoc
punctiforme) 		4 / 7 ARG A  50
ASN B  36
HIS A  72
ILE A  18
 None
 1.41A 1tdnA-4lx3A:
undetectable		 1tdnA-4lx3A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
NUCLEIC ACID
BINDING, OB-FOLD,
TRNA/HELICASE-TYPE
(Nostoc
punctiforme;
Nostoc
punctiforme) 		5 / 11 GLY B  31
ALA B  27
PHE B  32
ALA B  34
VAL A  33
 None
 1.14A 1ukbA-4lx3B:
undetectable		 1ukbA-4lx3B:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
(Nostoc
punctiforme) 		3 / 3 ILE A  39
MET A  95
ARG A  96
 None
 0.95A 4lnxA-4lx3A:
undetectable		 4lnxA-4lx3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
NUCLEIC ACID
BINDING, OB-FOLD,
TRNA/HELICASE-TYPE
(Nostoc
punctiforme;
Nostoc
punctiforme) 		3 / 3 ARG B   7
GLU A  86
TYR A  58
 None
 1.02A 4r29D-4lx3B:
undetectable		 4r29D-4lx3B:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_B_IMNB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lx3 DNA POLYMERASE III,
ALPHA SUBUNIT
NUCLEIC ACID
BINDING, OB-FOLD,
TRNA/HELICASE-TYPE
(Nostoc
punctiforme) 		5 / 11 GLY A  19
SER A   3
ALA A  68
LEU B  28
ILE B  18
 None
 1.19A 4xumB-4lx3A:
undetectable		 4xumB-4lx3A:
18.45