SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_2
(ADENOSINE DEAMINASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 LEU A 385
LEU A 346
SER A 405
LEU A 406
 GOL  A 704 (-4.4A)
GOL  A 704 ( 4.6A)
None
None
 1.02A 1a4lC-4lxfA:
6.8		 1a4lC-4lxfA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 126
ILE A  86
PHE A 119
PRO A  89
ILE A 232
 None
 1.06A 1dg5A-4lxfA:
undetectable		 1dg5A-4lxfA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 211
LEU A 209
VAL A 223
ILE A 224
PHE A 260
 None
 1.39A 1q6iA-4lxfA:
undetectable		 1q6iA-4lxfA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ASP A 238
ILE A 224
GLY A 234
ILE A 134
ALA A 279
 None
 1.07A 1sh9B-4lxfA:
undetectable		 1sh9B-4lxfA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T85_A_CAMA422_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.00A 1t85A-4lxfA:
undetectable		 1t85A-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 0.97A 1t87A-4lxfA:
undetectable		 1t87A-4lxfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PHE A 106
TYR A 164
TYR A 163
 None
 0.97A 1x70B-4lxfA:
undetectable		 1x70B-4lxfA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 487
GLU A 555
HIS A 495
 None
None
GOL  A 702 (-4.3A)
 0.90A 1xwfA-4lxfA:
undetectable		 1xwfA-4lxfA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 487
GLU A 555
HIS A 495
 None
None
GOL  A 702 (-4.3A)
 0.91A 1xwfB-4lxfA:
undetectable		 1xwfB-4lxfA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_C_ADNC433_2
(ADENOSYLHOMOCYSTEINA
SE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 THR A 487
GLU A 555
HIS A 495
 None
None
GOL  A 702 (-4.3A)
 0.87A 1xwfC-4lxfA:
undetectable		 1xwfC-4lxfA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRC_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.00A 1yrcA-4lxfA:
undetectable		 1yrcA-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YRD_A_CAMA420_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.01A 1yrdA-4lxfA:
undetectable		 1yrdA-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A  83
ILE A 418
MET A 420
LEU A  88
 None
 0.81A 1zgyA-4lxfA:
undetectable		 1zgyA-4lxfA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A 471
ILE A 418
LEU A 482
LEU A  78
LEU A  81
 None
 1.24A 2a15A-4lxfA:
undetectable		 2a15A-4lxfA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_A_CAMA1420_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.04A 2feuA-4lxfA:
undetectable		 2feuA-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FEU_B_CAMB1421_0
(CYTOCHROME P450-CAM)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 0.99A 2feuB-4lxfA:
undetectable		 2feuB-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 PRO A 214
ALA A 215
ASP A 212
ASP A 162
 None
 1.16A 2nyuB-4lxfA:
undetectable		 2nyuB-4lxfA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA702_0
(FERROCHELATASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 406
PRO A 407
ARG A 313
 None
 0.63A 2qd5A-4lxfA:
undetectable		 2qd5A-4lxfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 PHE A  31
PHE A  91
PHE A 226
ILE A  86
 None
 1.15A 2v0mD-4lxfA:
undetectable		 2v0mD-4lxfA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 346
MET A 311
MET A 304
 GOL  A 704 ( 4.6A)
None
None
 0.67A 2vavF-4lxfA:
undetectable		 2vavF-4lxfA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 497
GLY A 408
LYS A  45
HIS A  46
 None
None
GOL  A 703 (-3.7A)
GOL  A 703 (-4.5A)
 1.27A 2yldA-4lxfA:
undetectable		 2yldA-4lxfA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUI_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.01A 2zuiA-4lxfA:
undetectable		 2zuiA-4lxfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWT_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.02A 2zwtA-4lxfA:
undetectable		 2zwtA-4lxfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWU_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.01A 2zwuA-4lxfA:
undetectable		 2zwuA-4lxfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.04A 3fwfA-4lxfA:
undetectable		 3fwfA-4lxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWF_B_CAMB420_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.04A 3fwfB-4lxfA:
undetectable		 3fwfB-4lxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWI_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.03A 3fwiA-4lxfA:
undetectable		 3fwiA-4lxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWJ_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.02A 3fwjA-4lxfA:
undetectable		 3fwjA-4lxfA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 225
ASP A  27
ASP A 222
 None
 0.91A 3jb2A-4lxfA:
undetectable		 3jb2A-4lxfA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 301
VAL A 264
VAL A 240
ALA A 279
 None
 1.00A 3kp6B-4lxfA:
undetectable		 3kp6B-4lxfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L63_A_CAMA440_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.03A 3l63A-4lxfA:
undetectable		 3l63A-4lxfA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLN A 474
GLY A 415
GLY A 419
GLN A 437
TYR A  77
 None
 1.30A 3t7sC-4lxfA:
undetectable		 3t7sC-4lxfA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.00A 3wrhA-4lxfA:
undetectable		 3wrhA-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.02A 3wrjA-4lxfA:
undetectable		 3wrjA-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRL_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.01A 3wrlA-4lxfA:
undetectable		 3wrlA-4lxfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRM_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.02A 3wrmA-4lxfA:
undetectable		 3wrmA-4lxfA:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_1
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		6 / 10 MET A 488
GLU A 555
THR A 557
PHE A 579
TYR A 580
TRP A 581
 None
 0.34A 3zoaA-4lxfA:
57.7		 3zoaA-4lxfA:
80.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 536
PHE A 537
PRO A 538
 None
 0.39A 3zoaB-4lxfA:
58.9		 3zoaB-4lxfA:
80.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 497
GLY A 408
LYS A  45
HIS A  46
 None
None
GOL  A 703 (-3.7A)
GOL  A 703 (-4.5A)
 1.30A 3zwiA-4lxfA:
undetectable		 3zwiA-4lxfA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 421
ILE A 434
VAL A 469
SER A 459
 None
 1.06A 4d33A-4lxfA:
undetectable		 4d33A-4lxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLY A 421
ILE A 434
VAL A 469
SER A 459
 None
 1.05A 4d33B-4lxfA:
undetectable		 4d33B-4lxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 GLY A 421
ILE A 434
VAL A 469
SER A 459
 None
 1.07A 4d39B-4lxfA:
undetectable		 4d39B-4lxfA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ALA A 473
ILE A 418
LEU A 482
ASN A 470
 None
 1.18A 4g19A-4lxfA:
undetectable		 4g19A-4lxfA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 1.00A 4l4aA-4lxfA:
undetectable		 4l4aA-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 THR A 142
LEU A 209
VAL A 216
VAL A  23
 None
 1.05A 4l4gA-4lxfA:
undetectable		 4l4gA-4lxfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4G_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 TYR A 164
THR A 142
VAL A 216
VAL A  23
 None
 0.92A 4l4gA-4lxfA:
undetectable		 4l4gA-4lxfA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 136
TYR A 101
TRP A  87
 None
 1.30A 4p7nA-4lxfA:
14.3		 4p7nA-4lxfA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  76
LEU A 122
ILE A  72
GLY A  70
VAL A  52
 None
 1.11A 4y8wA-4lxfA:
undetectable		 4y8wA-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  76
LEU A 122
ILE A  72
GLY A  70
VAL A  52
 None
 1.07A 4y8wB-4lxfA:
undetectable		 4y8wB-4lxfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 343
ILE A 344
PHE A 345
VAL A 288
LEU A 346
 None
None
None
None
GOL  A 704 ( 4.6A)
 1.20A 5nz0A-4lxfA:
undetectable		 5nz0A-4lxfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 TRP A 342
GLY A 343
ILE A 344
PHE A 345
VAL A 288
 None
 1.09A 5nz0A-4lxfA:
undetectable		 5nz0A-4lxfA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WQP_A_NCAA302_0
(PROBABLE
DEHYDROGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 MET A 316
MET A 375
TYR A 369
MET A 356
 None
 1.39A 5wqpA-4lxfA:
undetectable		 5wqpA-4lxfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 PHE A 345
ILE A 344
PRO A 334
THR A 333
 None
 1.12A 5x23A-4lxfA:
undetectable		 5x23A-4lxfA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ASN A 348
HIS A 349
ASP A 422
GLY A 431
 GOL  A 705 (-2.9A)
GOL  A 705 (-4.4A)
None
None
 1.09A 5x7pA-4lxfA:
2.6		 5x7pA-4lxfA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 234
PRO A 273
GLY A 274
ASP A 136
ASP A 233
 None
 1.33A 5yniA-4lxfA:
undetectable		 5yniA-4lxfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 234
PRO A 273
GLY A 274
ASP A 136
ASP A 233
 None
 1.34A 5ynmA-4lxfA:
undetectable		 5ynmA-4lxfA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 356
ASP A 363
ARG A 320
 None
 0.88A 5z6jA-4lxfA:
undetectable		 5z6jA-4lxfA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 356
ASP A 363
ARG A 320
 None
 1.01A 5z6kA-4lxfA:
undetectable		 5z6kA-4lxfA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 284
PRO A 334
ILE A 329
PRO A 309
 None
 1.12A 6a4iA-4lxfA:
undetectable		 6a4iA-4lxfA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  71
LEU A 122
ALA A 125
ALA A 126
 None
None
SO4  A 707 ( 3.9A)
None
 0.82A 6a7jA-4lxfA:
undetectable		 6a7jA-4lxfA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 SER A 459
LEU A 389
GLY A 419
ASP A 416
ILE A 434
 None
None
None
GOL  A 704 (-3.5A)
None
 1.38A 6dwnA-4lxfA:
undetectable		 6dwnA-4lxfA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4lxf TREHALOSE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 8 ARG A 201
HIS A 200
GLU A 245
GLU A 252
 None
None
CA  A 701 (-2.8A)
None
 1.21A 6mn4A-4lxfA:
undetectable		 6mn4A-4lxfA:
19.49