SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GM7_B_PNNB1577_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 PHE A  90
ALA A  59
PHE A  44
ILE A  20
 None
 1.09A 1gm7A-4lxiA:
undetectable
1gm7B-4lxiA:
undetectable		 1gm7A-4lxiA:
23.02
1gm7B-4lxiA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 4 LYS A 201
ALA A 200
MET A 150
 None
None
22J  A 301 ( 3.8A)
 1.06A 1hk3A-4lxiA:
undetectable		 1hk3A-4lxiA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 GLN A 238
LEU A 125
GLY A 103
GLY A 107
ALA A 130
 None
 1.17A 1httC-4lxiA:
2.8		 1httC-4lxiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 4 THR A  84
LEU A  87
VAL A  31
LEU A  30
 None
 0.92A 1mz9D-4lxiA:
undetectable		 1mz9D-4lxiA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 THR A 109
GLY A 107
GLY A  33
GLY A  34
VAL A  31
 None
None
22J  A 301 (-3.4A)
22J  A 301 (-3.7A)
None
 0.88A 1n2xB-4lxiA:
3.2		 1n2xB-4lxiA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 11 PHE A 273
PHE A 272
PHE A  90
LEU A  87
VAL A  31
 None
 1.40A 1q23J-4lxiA:
undetectable		 1q23J-4lxiA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 11 GLY A  33
ALA A 105
ALA A 131
LEU A 205
HIS A 255
 22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
22J  A 301 ( 4.7A)
None
22J  A 301 ( 4.5A)
 0.75A 1ukbA-4lxiA:
37.9		 1ukbA-4lxiA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 11 GLY A  33
ALA A 105
ALA A 131
VAL A 230
HIS A 255
 22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
22J  A 301 ( 4.7A)
None
22J  A 301 ( 4.5A)
 0.81A 1ukbA-4lxiA:
37.9		 1ukbA-4lxiA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 11 GLY A  34
ALA A 105
ALA A 131
LEU A 205
HIS A 255
 22J  A 301 (-3.7A)
22J  A 301 (-2.8A)
22J  A 301 ( 4.7A)
None
22J  A 301 ( 4.5A)
 1.04A 1ukbA-4lxiA:
37.9		 1ukbA-4lxiA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 11 GLY A  34
ALA A 105
ALA A 131
VAL A 230
HIS A 255
 22J  A 301 (-3.7A)
22J  A 301 (-2.8A)
22J  A 301 ( 4.7A)
None
22J  A 301 ( 4.5A)
 1.09A 1ukbA-4lxiA:
37.9		 1ukbA-4lxiA:
34.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 7 LEU A  28
PHE A 273
ILE A 102
PHE A 265
 None
 0.67A 2opxA-4lxiA:
2.5		 2opxA-4lxiA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 LEU A 101
ILE A 102
ALA A 115
PHE A  44
HIS A  32
 None
 1.41A 2qo4A-4lxiA:
undetectable		 2qo4A-4lxiA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 HIS A 255
ASP A 227
ILE A 102
GLY A  33
ALA A 105
 22J  A 301 ( 4.5A)
None
None
22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
 1.11A 3sudB-4lxiA:
undetectable		 3sudB-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 HIS A 255
ASP A 227
ILE A 102
GLY A 107
ALA A 105
 22J  A 301 ( 4.5A)
None
None
None
22J  A 301 (-2.8A)
 0.91A 3sudB-4lxiA:
undetectable		 3sudB-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 HIS A 255
ASP A 227
ILE A 102
GLY A  33
ALA A 105
 22J  A 301 ( 4.5A)
None
None
22J  A 301 (-3.4A)
22J  A 301 (-2.8A)
 0.98A 3sudC-4lxiA:
undetectable		 3sudC-4lxiA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 7 PHE A  90
LEU A  87
VAL A  29
PHE A  44
 None
 1.01A 4wnvD-4lxiA:
undetectable		 4wnvD-4lxiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 7 GLY A  34
GLY A  35
ALA A  38
ILE A 162
 22J  A 301 (-3.7A)
22J  A 301 (-3.1A)
22J  A 301 (-3.4A)
None
 0.74A 4yjiA-4lxiA:
1.4		 4yjiA-4lxiA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 4 ARG A 160
GLY A 158
GLU A 157
 None
 0.63A 4z2dB-4lxiA:
undetectable
4z2dC-4lxiA:
3.0		 4z2dB-4lxiA:
19.84
4z2dC-4lxiA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		6 / 9 LEU A 215
ALA A 115
LEU A 125
ALA A 111
LEU A 127
LEU A 212
 None
 0.91A 4z91F-4lxiA:
undetectable
4z91G-4lxiA:
undetectable
4z91H-4lxiA:
undetectable
4z91I-4lxiA:
undetectable
4z91J-4lxiA:
undetectable		 4z91F-4lxiA:
19.94
4z91G-4lxiA:
19.94
4z91H-4lxiA:
19.94
4z91I-4lxiA:
19.94
4z91J-4lxiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 3 TYR A 193
THR A 189
THR A 196
 None
 0.83A 5aoxB-4lxiA:
undetectable		 5aoxB-4lxiA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CVT_B_ACTB200_0
(N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
MUTASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 3 ASN A  43
ALA A  38
ARG A 180
 22J  A 301 (-2.9A)
22J  A 301 (-3.4A)
22J  A 301 (-2.9A)
 0.74A 5cvtB-4lxiA:
4.1		 5cvtB-4lxiA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 GLY A  35
GLY A  34
ASP A  39
HIS A  32
 22J  A 301 (-3.1A)
22J  A 301 (-3.7A)
None
None
 0.80A 5f8yA-4lxiA:
undetectable		 5f8yA-4lxiA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 12 MET A 258
VAL A 257
GLY A  40
PHE A  65
TYR A 193
 None
 1.24A 5igiA-4lxiA:
undetectable		 5igiA-4lxiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 3 SER A 208
TYR A 207
TYR A 206
 None
 0.58A 5lakA-4lxiA:
0.7
5lakI-4lxiA:
undetectable		 5lakA-4lxiA:
19.41
5lakI-4lxiA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		3 / 3 SER A 208
TYR A 207
TYR A 206
 None
 0.52A 5lakC-4lxiA:
undetectable
5lakJ-4lxiA:
undetectable		 5lakC-4lxiA:
19.41
5lakJ-4lxiA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		5 / 10 LEU A  30
HIS A  32
ILE A 102
GLY A 103
GLY A 107
 None
 0.87A 5o96C-4lxiA:
undetectable
5o96D-4lxiA:
undetectable		 5o96C-4lxiA:
20.00
5o96D-4lxiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA413_0
(AROMATIC
PEROXYGENASE)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 7 GLN A 268
GLY A 129
GLY A 223
VAL A 235
 None
 0.91A 6ekzA-4lxiA:
undetectable		 6ekzA-4lxiA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 ASP A  46
ILE A 259
TRP A 256
TYR A 179
 None
None
22J  A 301 (-4.0A)
None
 1.20A 6hisA-4lxiA:
undetectable
6hisB-4lxiA:
undetectable		 6hisA-4lxiA:
18.59
6hisB-4lxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 ASP A  46
ILE A 259
TRP A 256
TYR A 179
 None
None
22J  A 301 (-4.0A)
None
 1.21A 6hisB-4lxiA:
undetectable
6hisC-4lxiA:
undetectable		 6hisB-4lxiA:
18.59
6hisC-4lxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 ASP A  46
ILE A 259
TRP A 256
TYR A 179
 None
None
22J  A 301 (-4.0A)
None
 1.20A 6hisC-4lxiA:
undetectable
6hisD-4lxiA:
undetectable		 6hisC-4lxiA:
18.59
6hisD-4lxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 ASP A  46
ILE A 259
TRP A 256
TYR A 179
 None
None
22J  A 301 (-4.0A)
None
 1.20A 6hisD-4lxiA:
undetectable
6hisE-4lxiA:
undetectable		 6hisD-4lxiA:
18.59
6hisE-4lxiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 4lxi MCP HYDROLASE
(Sphingomonas
wittichii) 		4 / 8 TYR A 179
ASP A  46
ILE A 259
TRP A 256
 None
None
None
22J  A 301 (-4.0A)
 1.21A 6hisA-4lxiA:
undetectable
6hisE-4lxiA:
undetectable		 6hisA-4lxiA:
18.59
6hisE-4lxiA:
18.59