SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_A_FOLA187_0
(DIHYDROFOLATE
REDUCTASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 ILE A  15
ALA A  40
GLN A 263
ILE A  49
PRO A  50
 None
 1.04A 1dhfA-4lxlA:
undetectable		 1dhfA-4lxlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 6 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.33A 1mxdA-4lxlA:
undetectable		 1mxdA-4lxlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 7 ASN A 150
TRP A  54
HIS A 202
TYR A 200
 None
 1.34A 1mxgA-4lxlA:
undetectable		 1mxgA-4lxlA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUA_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 10 ALA A 287
TRP A 209
LEU A 201
GLY A 266
PHE A 268
 None
 1.42A 1ruaH-4lxlA:
undetectable
1ruaL-4lxlA:
undetectable		 1ruaH-4lxlA:
20.38
1ruaL-4lxlA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 5 PRO A 131
GLY A 283
ASN A 281
GLY A 180
 None
 1.12A 1zlqA-4lxlA:
undetectable		 1zlqA-4lxlA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 6 TYR A 254
GLY A 230
PHE A 228
SER A 232
 None
 1.28A 2a3cB-4lxlA:
undetectable		 2a3cB-4lxlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6001_0
(PANTOTHENATE KINASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 11 TYR A 142
GLY A 152
ILE A 198
THR A 156
ARG A 155
 None
 1.17A 2f9wA-4lxlA:
undetectable
2f9wB-4lxlA:
undetectable		 2f9wA-4lxlA:
27.75
2f9wB-4lxlA:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 7 ILE A 261
PHE A 115
ASP A 116
GLU A 119
 None
 1.07A 2qebA-4lxlA:
undetectable		 2qebA-4lxlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_B_HSMB145_1
(D7R4 PROTEIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 7 ILE A 261
PHE A 115
ASP A 116
GLU A 119
 None
 1.07A 2qebB-4lxlA:
undetectable		 2qebB-4lxlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 8 ILE A 151
PHE A  28
LEU A 154
PHE A 292
 None
 0.88A 2vdbA-4lxlA:
undetectable		 2vdbA-4lxlA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 6 ARG A 296
VAL A  32
ILE A  35
TYR A 196
 None
 1.21A 2yfbB-4lxlA:
undetectable		 2yfbB-4lxlA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 5 ASP A  64
ILE A 137
ILE A  63
GLY A  96
 None
 0.86A 3bufA-4lxlA:
undetectable		 3bufA-4lxlA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 4 ILE A 246
PHE A 227
ILE A 250
THR A 244
 None
 0.96A 3ia4A-4lxlA:
undetectable		 3ia4A-4lxlA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		3 / 3 LYS A 242
ILE A 270
PHE A 268
 PD2  A 401 (-2.9A)
None
None
 0.90A 3j7zS-4lxlA:
undetectable
3j7za-4lxlA:
undetectable		 3j7zS-4lxlA:
15.30
3j7za-4lxlA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 ASN A 199
SER A 289
GLU A 191
VAL A 161
GLU A 162
 PD2  A 401 ( 4.5A)
None
NI  A 402 ( 2.6A)
None
None
 1.48A 3jayA-4lxlA:
undetectable		 3jayA-4lxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 ASN A 199
SER A 289
GLU A 191
VAL A 161
GLU A 162
 PD2  A 401 ( 4.5A)
None
NI  A 402 ( 2.6A)
None
None
 1.37A 3jb2A-4lxlA:
undetectable		 3jb2A-4lxlA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 5 GLU A  36
TYR A 196
PHE A 272
TYR A 300
 None
 1.50A 4twdA-4lxlA:
undetectable
4twdE-4lxlA:
undetectable		 4twdA-4lxlA:
20.57
4twdE-4lxlA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 5 TYR A 300
GLU A  36
TYR A 196
PHE A 272
 None
 1.46A 4twdC-4lxlA:
undetectable
4twdD-4lxlA:
undetectable		 4twdC-4lxlA:
20.57
4twdD-4lxlA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 5 TYR A 300
GLU A  36
TYR A 196
PHE A 272
 None
 1.49A 4twdH-4lxlA:
0.0
4twdI-4lxlA:
undetectable		 4twdH-4lxlA:
20.57
4twdI-4lxlA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2O_B_CLQB1079_0
(SAPOSIN-B)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		3 / 3 MET A  93
GLU A  97
LEU A 101
 None
 0.75A 4v2oB-4lxlA:
undetectable		 4v2oB-4lxlA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		3 / 3 ASP A  64
LEU A 141
ARG A  57
 None
 0.91A 5e8qA-4lxlA:
undetectable		 5e8qA-4lxlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZ0_A_ZLDA301_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ETHR)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		5 / 12 GLY A  81
ILE A 246
THR A  84
VAL A  76
LEU A 223
 None
 1.37A 5nz0A-4lxlA:
undetectable		 5nz0A-4lxlA:
21.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		4 / 6 GLU A 221
ALA A 237
LEU A 239
TYR A 276
 None
 0.22A 5phhA-4lxlA:
45.5		 5phhA-4lxlA:
69.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UVM_B_ADNB207_1
(HISTIDINE TRIAD
(HIT) PROTEIN)		 4lxl LYSINE-SPECIFIC
DEMETHYLASE 4B
(Homo
sapiens) 		6 / 12 VAL A  95
PHE A 179
ILE A  68
ILE A 137
LEU A 177
HIS A 202
 None
 1.34A 5uvmB-4lxlA:
undetectable		 5uvmB-4lxlA:
20.89