SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4lxo FIBRONECTIN
(Homo
sapiens) 		4 / 5 ILE A1354
ARG A1403
LEU A1400
ASN A1401
 None
 1.13A 1y0xX-4lxoA:
undetectable		 1y0xX-4lxoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4lxo FIBRONECTIN
(Homo
sapiens) 		4 / 7 ILE A1485
VAL A1425
ALA A1428
THR A1429
 None
 0.93A 6cduC-4lxoA:
undetectable
6cduD-4lxoA:
1.8		 6cduC-4lxoA:
20.91
6cduD-4lxoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4lxo FIBRONECTIN
(Homo
sapiens) 		4 / 7 ALA A1428
THR A1429
ILE A1485
VAL A1425
 None
 0.95A 6cduF-4lxoA:
undetectable
6cduJ-4lxoA:
undetectable		 6cduF-4lxoA:
20.91
6cduJ-4lxoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4lxo FIBRONECTIN
(Homo
sapiens) 		3 / 3 ARG A1508
LYS A1478
TYR A1483
 None
 1.20A 6gnaA-4lxoA:
undetectable		 6gnaA-4lxoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4lxo FIBRONECTIN
(Homo
sapiens) 		3 / 3 ARG A1508
LYS A1478
TYR A1483
 None
 1.20A 6gnbA-4lxoA:
undetectable		 6gnbA-4lxoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN1_B_LLLB302_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE)		 4lxo FIBRONECTIN
(Homo
sapiens) 		5 / 10 ASP A1498
TYR A1393
ASP A1337
THR A1344
THR A1415
 None
 1.21A 6mn1B-4lxoA:
undetectable		 6mn1B-4lxoA:
16.23