SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 4 THR A 437
LEU A 416
LEU A 368
GLN A 365
 None
 1.00A 1fbmA-4lxrA:
undetectable		 1fbmA-4lxrA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 11 LEU A 295
LEU A 324
VAL A 298
LEU A 314
GLN A 318
 None
 1.37A 1kt7A-4lxrA:
undetectable		 1kt7A-4lxrA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		3 / 3 ASP A 336
LEU A 337
HIS A 262
 None
 0.70A 1qknA-4lxrA:
undetectable		 1qknA-4lxrA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 THR A 113
GLY A 111
HIS A 145
ILE A  77
LEU A  67
 None
 1.14A 1r30B-4lxrA:
undetectable		 1r30B-4lxrA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_A_NDRA1001_0
(PROGESTERONE
RECEPTOR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 445
LEU A 480
LEU A 504
LEU A 475
MET A 496
 None
 1.43A 1sqnA-4lxrA:
undetectable		 1sqnA-4lxrA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 7 PHE A 410
ARG A 396
MET A 421
LEU A 445
 None
 0.98A 2eikA-4lxrA:
undetectable
2eikJ-4lxrA:
undetectable		 2eikA-4lxrA:
20.28
2eikJ-4lxrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 6 PRO A 221
MET A 220
ASP A 172
ASP A 195
 None
 1.38A 2lh8A-4lxrA:
undetectable		 2lh8A-4lxrA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.04A 2oipD-4lxrA:
undetectable		 2oipD-4lxrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_E_MTXE621_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.07A 2oipE-4lxrA:
undetectable		 2oipE-4lxrA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OK6_H_BEZH2001_0
(AROMATIC AMINE
DEHYDROGENASE, LARGE
SUBUNIT
AROMATIC AMINE
DEHYDROGENASE, SMALL
SUBUNIT)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 10 PHE A 241
LEU A 268
GLY A 249
LEU A 226
PHE A 265
 None
 1.24A 2ok6A-4lxrA:
1.1
2ok6H-4lxrA:
undetectable		 2ok6A-4lxrA:
18.19
2ok6H-4lxrA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 PHE A 193
LEU A 199
MET A 220
ILE A 185
SER A 177
 None
 1.27A 2pnjB-4lxrA:
undetectable		 2pnjB-4lxrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 8 ILE A 409
GLY A 404
MET A 421
ILE A 429
 None
 0.83A 2qwxA-4lxrA:
undetectable
2qwxB-4lxrA:
undetectable		 2qwxA-4lxrA:
14.30
2qwxB-4lxrA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 6 GLU A 186
ALA A 183
LEU A 181
THR A 159
 None
 0.97A 2roxB-4lxrA:
undetectable		 2roxB-4lxrA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_B_NDRB1000_0
(PROGESTERONE
RECEPTOR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 445
LEU A 480
LEU A 504
LEU A 475
MET A 496
 None
 1.47A 2w8yB-4lxrA:
undetectable		 2w8yB-4lxrA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 10 LEU A 440
LEU A 480
ILE A 429
PHE A 434
THR A 477
 None
 1.12A 2w9gA-4lxrA:
undetectable		 2w9gA-4lxrA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 5 ILE A 537
ARG A 591
MET A 529
THR A 530
 None
NAG  A2010 (-2.9A)
None
NAG  A2009 (-3.5A)
 1.20A 3abkN-4lxrA:
undetectable
3abkW-4lxrA:
undetectable		 3abkN-4lxrA:
20.28
3abkW-4lxrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI9_X_SAMX501_0
(UPF0217 PROTEIN
MJ1640)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 9 ILE A 250
GLY A 249
SER A 277
LEU A 276
GLU A 297
 None
 1.01A 3ai9X-4lxrA:
undetectable		 3ai9X-4lxrA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 GLY A 735
ILE A 721
LEU A 748
LEU A 716
LEU A 712
 None
 1.08A 3cs8A-4lxrA:
undetectable		 3cs8A-4lxrA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRB_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 11 LEU A 440
LEU A 480
ILE A 429
PHE A 434
THR A 477
 None
 1.09A 3frbX-4lxrA:
undetectable		 3frbX-4lxrA:
11.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.14A 3hj3B-4lxrA:
undetectable		 3hj3B-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_D_MTXD615_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.10A 3hj3D-4lxrA:
undetectable		 3hj3D-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 4 ILE A 459
ARG A 427
ILE A 486
THR A 463
 None
 1.22A 3ia4C-4lxrA:
undetectable		 3ia4C-4lxrA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 THR A 530
SER A 598
ILE A 537
ASP A 557
ARG A 591
 NAG  A2009 (-3.5A)
None
None
NAG  A2009 (-3.8A)
NAG  A2010 (-2.9A)
 1.31A 3iv6D-4lxrA:
undetectable		 3iv6D-4lxrA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 7 VAL A 247
PHE A 217
LEU A 228
ILE A 202
 None
 0.96A 3rfmA-4lxrA:
undetectable		 3rfmA-4lxrA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 8 TYR A  52
VAL A  75
ILE A  96
ALA A  33
 None
 0.96A 4eyzA-4lxrA:
undetectable		 4eyzA-4lxrA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 8 TYR A  52
VAL A  75
ILE A  96
ALA A  33
 None
 0.95A 4eyzB-4lxrA:
undetectable		 4eyzB-4lxrA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 349
LEU A 354
ILE A 344
SER A 332
THR A 309
 None
 1.11A 4f4dB-4lxrA:
undetectable		 4f4dB-4lxrA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 MET A 421
LEU A 419
LEU A 392
ILE A 405
ILE A 409
 None
 1.18A 4j24B-4lxrA:
undetectable		 4j24B-4lxrA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.12A 4ky8A-4lxrA:
undetectable		 4ky8A-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.12A 4ky8B-4lxrA:
undetectable		 4ky8B-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.11A 4ky8C-4lxrA:
undetectable		 4ky8C-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.12A 4ky8D-4lxrA:
undetectable		 4ky8D-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.08A 4ky8E-4lxrA:
undetectable		 4ky8E-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 ILE A 274
VAL A 298
LEU A 324
LEU A 295
LEU A 288
 None
 1.38A 4m11A-4lxrA:
undetectable		 4m11A-4lxrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_C_MXMC606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 ILE A 274
VAL A 298
LEU A 324
LEU A 295
LEU A 288
 None
 1.33A 4m11C-4lxrA:
undetectable		 4m11C-4lxrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_D_MXMD606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 ILE A 274
VAL A 298
LEU A 324
LEU A 295
LEU A 288
 None
 1.34A 4m11D-4lxrA:
undetectable		 4m11D-4lxrA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 5 ASN A 702
LEU A 704
SER A 722
LEU A 719
 None
 1.11A 4n09C-4lxrA:
undetectable		 4n09C-4lxrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		3 / 3 SER A 511
ASP A 516
GLN A 462
 None
 0.82A 4oltA-4lxrA:
undetectable
4oltB-4lxrA:
undetectable		 4oltA-4lxrA:
14.34
4oltB-4lxrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.16A 4q0dA-4lxrA:
undetectable		 4q0dA-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.15A 4q0dB-4lxrA:
undetectable		 4q0dB-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
SER A 406
LEU A 445
 None
 1.19A 4q0dC-4lxrA:
undetectable		 4q0dC-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
SER A 406
LEU A 445
 None
 1.19A 4q0dD-4lxrA:
undetectable		 4q0dD-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 LEU A 381
LEU A 397
SER A 422
ILE A 405
LEU A 445
 None
 1.16A 4q0dE-4lxrA:
undetectable		 4q0dE-4lxrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		3 / 3 GLN A 462
SER A 511
ASP A 516
 None
 0.76A 4qwpA-4lxrA:
undetectable
4qwpB-4lxrA:
undetectable		 4qwpA-4lxrA:
14.34
4qwpB-4lxrA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 11 ASP A 451
ARG A 427
ILE A 465
TYR A 489
ILE A 485
 None
 1.15A 5hw8D-4lxrA:
undetectable		 5hw8D-4lxrA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 7 PHE A 410
ARG A 396
MET A 421
LEU A 445
 None
 0.94A 5iy5N-4lxrA:
undetectable
5iy5W-4lxrA:
undetectable		 5iy5N-4lxrA:
20.28
5iy5W-4lxrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 4 ASN A 702
LEU A 704
SER A 722
LEU A 719
 None
 1.08A 5kb5A-4lxrA:
undetectable		 5kb5A-4lxrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 10 ILE A 648
TRP A 723
ILE A 707
LEU A 699
ALA A 700
 None
 1.33A 5zjiB-4lxrA:
undetectable		 5zjiB-4lxrA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 10 LEU A 226
ALA A 244
PRO A 213
GLU A 187
SER A 190
 None
 1.50A 6b89A-4lxrA:
undetectable		 6b89A-4lxrA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 7 TYR A 121
CSS A  56
CSS A  43
LEU A  67
 None
 1.22A 6cnkB-4lxrA:
undetectable
6cnkC-4lxrA:
undetectable		 6cnkB-4lxrA:
8.12
6cnkC-4lxrA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA814_0
(UNCHARACTERIZED
PROTEIN)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		4 / 5 GLN A 322
ASN A 346
THR A 345
LEU A 369
 None
NAG  A2001 (-1.8A)
None
NAG  A2001 ( 4.4A)
 1.22A 6d8pA-4lxrA:
undetectable		 6d8pA-4lxrA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 12 SER A 348
LEU A 402
ASN A 400
ASP A 372
PHE A 386
 None
 1.37A 6dwnB-4lxrA:
undetectable		 6dwnB-4lxrA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 4lxr PROTEIN TOLL
(Drosophila
melanogaster) 		5 / 11 PHE A 155
ILE A 131
LEU A 130
LEU A 179
ILE A 165
 None
 1.47A 6fgcA-4lxrA:
undetectable		 6fgcA-4lxrA:
6.89