SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lxy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		4 / 4 ILE A  20
LEU A  48
VAL A  32
ILE A  57
 None
 0.92A 1fm6D-4lxyA:
undetectable		 1fm6D-4lxyA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		4 / 8 LYS A 263
GLU A 240
ILE A 242
ILE A 255
 None
 0.98A 2j9dJ-4lxyA:
undetectable
2j9dK-4lxyA:
undetectable
2j9dL-4lxyA:
undetectable		 2j9dJ-4lxyA:
20.74
2j9dK-4lxyA:
20.74
2j9dL-4lxyA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		4 / 8 ARG A 192
PRO A 112
SER A 120
GLY A 105
 1YA  A 301 (-4.3A)
None
None
None
 1.13A 2qd3A-4lxyA:
2.8		 2qd3A-4lxyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 12 ILE A  65
PHE A  73
ALA A   7
ILE A 169
ILE A 173
 None
 0.95A 2rlcA-4lxyA:
undetectable		 2rlcA-4lxyA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		4 / 8 GLU A  85
ASN A  86
ASN A 129
ILE A 127
 None
None
None
1YA  A 301 (-4.3A)
 1.31A 3kp6A-4lxyA:
undetectable
3kp6B-4lxyA:
undetectable		 3kp6A-4lxyA:
21.66
3kp6B-4lxyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PMZ_E_TUBE220_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		4 / 6 GLN A 139
ILE A 136
SER A 188
SER A 187
 None
 1.34A 3pmzD-4lxyA:
undetectable		 3pmzD-4lxyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DJF_A_C2FA300_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 12 ASN A 202
ASP A 260
GLY A 258
ASN A 245
ILE A 210
 None
 1.49A 4djfA-4lxyA:
undetectable		 4djfA-4lxyA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A   6
ILE A  30
LEU A  21
ILE A  12
ASN A  10
 None
 1.30A 5vkqA-4lxyA:
undetectable
5vkqD-4lxyA:
undetectable		 5vkqA-4lxyA:
10.15
5vkqD-4lxyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  12
ASN A  10
ILE A   6
ILE A  30
LEU A  21
 None
 1.30A 5vkqA-4lxyA:
undetectable
5vkqB-4lxyA:
undetectable		 5vkqA-4lxyA:
10.15
5vkqB-4lxyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 ILE A  12
ASN A  10
ILE A   6
ILE A  30
LEU A  21
 None
 1.29A 5vkqC-4lxyA:
undetectable
5vkqD-4lxyA:
undetectable		 5vkqC-4lxyA:
10.15
5vkqD-4lxyA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A  51
LEU A  62
LEU A  76
GLY A   8
ASN A  35
 None
 1.37A 6r2eB-4lxyA:
undetectable		 6r2eB-4lxyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A  51
LEU A  62
LEU A  76
GLY A   8
ASN A  35
 None
 1.45A 6r2eC-4lxyA:
undetectable		 6r2eC-4lxyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_D_FFOD403_0
(THYMIDYLATE SYNTHASE)		 4lxy WLARD, A SUGAR
3N-FORMYL
TRANSFERASE
(Campylobacter
jejuni) 		5 / 10 PHE A  51
LEU A  62
LEU A  76
GLY A   8
ASN A  35
 None
 1.40A 6r2eD-4lxyA:
undetectable		 6r2eD-4lxyA:
21.87