SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lyk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA
(Escherichia
coli) 		3 / 3 ASP A 263
THR A 234
GLU A 164
 None
 0.86A 1pj7A-4lykA:
undetectable		 1pj7A-4lykA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA
(Escherichia
coli) 		4 / 5 ARG A 246
PHE A 249
LEU A 274
ALA A 276
 None
 1.32A 2e1qD-4lykA:
undetectable		 2e1qD-4lykA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA
(Escherichia
coli) 		3 / 3 ILE A 248
PHE A 211
HIS A 253
 None
 0.68A 3h0aA-4lykA:
undetectable		 3h0aA-4lykA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA
(Escherichia
coli) 		4 / 6 PHE A 206
ILE A 248
ALA A 245
ALA A 276
 None
 1.04A 3mdrB-4lykA:
undetectable		 3mdrB-4lykA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4lyk CYCLIC DI-GMP
PHOSPHODIESTERASE
YAHA
(Escherichia
coli) 		4 / 8 ALA A 116
ALA A 112
ALA A 163
SER A 166
 None
 0.80A 4twdF-4lykA:
undetectable
4twdG-4lykA:
undetectable
4twdH-4lykA:
undetectable
4twdI-4lykA:
undetectable
4twdJ-4lykA:
undetectable		 4twdF-4lykA:
22.12
4twdG-4lykA:
22.12
4twdH-4lykA:
22.12
4twdI-4lykA:
22.12
4twdJ-4lykA:
22.12