SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lyl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 7 TYR A 147
VAL A 160
ILE A 173
TYR A 174
GLY A 190
 None
 1.02A 11gsA-4lylA:
undetectable		 11gsA-4lylA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 7 TYR A 147
ILE A 173
TYR A 174
GLY A 190
 None
 0.86A 11gsB-4lylA:
undetectable		 11gsB-4lylA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13GS_A_SASA211_1
(GLUTATHIONE
S-TRANSFERASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 10 TYR A 147
VAL A 160
ILE A 173
TYR A 174
GLY A 190
 None
 1.07A 13gsA-4lylA:
undetectable		 13gsA-4lylA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 9 LEU A 177
ARG A 302
PHE A 184
LEU A 192
ALA A 303
 None
 1.37A 2bxeA-4lylA:
undetectable		 2bxeA-4lylA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 5 ILE A 230
LEU A 233
SER A 234
ARG A 237
 None
 0.75A 2byoA-4lylA:
undetectable		 2byoA-4lylA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 5 LEU A 244
LEU A 233
SER A 234
ARG A 237
 None
 0.99A 2byoA-4lylA:
undetectable		 2byoA-4lylA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 8 TYR A 147
VAL A 160
ILE A 173
GLY A 190
 None
 0.94A 2gssA-4lylA:
undetectable		 2gssA-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 8 TYR A 147
VAL A 160
ILE A 173
GLY A 190
 None
 0.94A 2gssB-4lylA:
undetectable		 2gssB-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 7 TYR A 147
VAL A 160
ILE A 173
GLY A 190
 None
 0.93A 3gssA-4lylA:
undetectable		 3gssA-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 7 VAL A 160
ILE A 173
TYR A 174
GLY A 190
 None
 0.98A 3gssA-4lylA:
undetectable		 3gssA-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 7 TYR A 147
VAL A 160
ILE A 173
GLY A 190
 None
 0.93A 3gssB-4lylA:
undetectable		 3gssB-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 7 VAL A 160
ILE A 173
TYR A 174
GLY A 190
 None
 0.98A 3gssB-4lylA:
undetectable		 3gssB-4lylA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ILE A 141
PHE A 284
HIS A 268
 None
 0.73A 3h0aA-4lylA:
undetectable		 3h0aA-4lylA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 10 ALA A 287
VAL A 200
ILE A 173
LEU A 192
ILE A 141
 None
 1.13A 3jw3A-4lylA:
undetectable		 3jw3A-4lylA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 9 ALA A 287
VAL A 200
ILE A 173
LEU A 192
ILE A 141
 None
 1.10A 3jw3B-4lylA:
undetectable		 3jw3B-4lylA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 11 PRO A 146
LEU A 203
VAL A 229
ALA A 228
ARG A 220
 None
 1.30A 3n23C-4lylA:
undetectable		 3n23C-4lylA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ARG A 237
THR A  88
TRP A  89
 None
 1.16A 4d7hA-4lylA:
undetectable		 4d7hA-4lylA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_A_ACTA603_0
(CHOLINE OXIDASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ARG A 115
HIS A 116
SER A 114
 None
 1.02A 4mjwA-4lylA:
undetectable
4mjwB-4lylA:
undetectable		 4mjwA-4lylA:
16.36
4mjwB-4lylA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJW_B_ACTB603_0
(CHOLINE OXIDASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 SER A 114
ARG A 115
HIS A 116
 None
 0.97A 4mjwA-4lylA:
undetectable
4mjwB-4lylA:
undetectable		 4mjwA-4lylA:
16.36
4mjwB-4lylA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ARG A 237
THR A  88
TRP A  89
 None
 1.16A 4ug5A-4lylA:
undetectable		 4ug5A-4lylA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ARG A 237
THR A  88
TRP A  89
 None
 1.11A 4uglA-4lylA:
undetectable		 4uglA-4lylA:
17.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		6 / 8 GLY A 143
GLN A 144
TYR A 147
PHE A 158
SER A 169
ASN A 204
 None
 1.01A 4wryA-4lylA:
31.3		 4wryA-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		6 / 8 GLY A 143
GLN A 144
TYR A 147
PHE A 158
SER A 169
HIS A 268
 None
 1.04A 4wryA-4lylA:
31.3		 4wryA-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 8 GLN A 144
TYR A 147
PHE A 158
SER A 169
HIS A 268
 None
 0.89A 4wrzA-4lylA:
30.6		 4wrzA-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		6 / 8 GLY A 143
GLN A 144
TYR A 147
PHE A 158
SER A 169
ASN A 204
 None
 1.02A 4wrzA-4lylA:
30.6		 4wrzA-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		5 / 7 GLY A 143
GLN A 144
TYR A 147
PHE A 158
ASN A 204
 None
 0.75A 4ws0A-4lylA:
30.7		 4ws0A-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		6 / 8 GLY A 143
GLN A 144
TYR A 147
PHE A 158
SER A 169
ASN A 204
 None
 0.92A 4ws1A-4lylA:
30.8		 4ws1A-4lylA:
39.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 8 TYR A 147
PHE A 158
SER A 169
HIS A 268
 None
 0.76A 4ws1A-4lylA:
30.8		 4ws1A-4lylA:
39.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ARG A 237
THR A  88
TRP A  89
 None
 1.13A 5g6cA-4lylA:
undetectable		 5g6cA-4lylA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		4 / 5 PHE A 242
THR A 255
ASP A 227
ASN A 204
 None
 1.44A 5ybbA-4lylA:
undetectable		 5ybbA-4lylA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4lyl URACIL-DNA
GLYCOSYLASE
(Gadus
morhua) 		3 / 3 ASN A 204
VAL A 109
HIS A 217
 None
 0.83A 6a5yD-4lylA:
undetectable		 6a5yD-4lylA:
16.30