SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lyp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 11 PRO A 203
TYR A 156
PHE A 211
HIS A 244
LEU A 231
 None
 1.44A 1c3sA-4lypA:
3.1		 1c3sA-4lypA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.05A 1c8lA-4lypA:
undetectable		 1c8lA-4lypA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 5 HIS A 379
TRP A 257
ALA A 305
TRP A 384
 TRS  A 503 (-4.3A)
TRS  A 503 (-3.7A)
None
None
 1.44A 1dy4A-4lypA:
undetectable		 1dy4A-4lypA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ALA A 335
SER A 386
TRP A 261
LEU A 283
 None
 1.22A 1gahA-4lypA:
undetectable		 1gahA-4lypA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.01A 1gfzA-4lypA:
undetectable		 1gfzA-4lypA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 ILE A 194
ILE A  57
ALA A  24
ASN A 352
THR A 112
 None
 1.27A 1jtxA-4lypA:
0.5		 1jtxA-4lypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.02A 1l5qA-4lypA:
undetectable		 1l5qA-4lypA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.01A 1l5qB-4lypA:
undetectable		 1l5qB-4lypA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 0.98A 1l7xA-4lypA:
undetectable		 1l7xA-4lypA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 0.98A 1l7xB-4lypA:
undetectable		 1l7xB-4lypA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4I_A_KANA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 8 ASP A 391
GLY A 375
SER A 362
THR A 363
 None
 0.90A 1m4iA-4lypA:
undetectable		 1m4iA-4lypA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 7 TYR A 319
PRO A 266
GLU A 259
ALA A 305
 None
 1.12A 1oniG-4lypA:
undetectable
1oniI-4lypA:
undetectable		 1oniG-4lypA:
16.19
1oniI-4lypA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_0
(N,N-DIMETHYLGLYCINE
OXIDASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 MET A 195
GLY A  23
ASN A  25
PHE A 348
PHE A 282
 None
 1.17A 1pj7A-4lypA:
undetectable		 1pj7A-4lypA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 LEU A 231
GLU A 202
TRP A 117
THR A 149
 None
GAI  A 501 ( 2.7A)
GAI  A 501 (-3.9A)
None
 1.13A 1qvuA-4lypA:
undetectable		 1qvuA-4lypA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 5 PRO A 266
PRO A 269
GLY A 271
TYR A 264
 None
 1.17A 2jkjD-4lypA:
undetectable		 2jkjD-4lypA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 5 PRO A 266
PRO A 269
GLY A 271
TYR A 264
 None
 1.17A 2jkjF-4lypA:
undetectable		 2jkjF-4lypA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 ASN A 201
GLU A 202
HIS A 255
GLU A 301
TRP A 354
 TRS  A 503 ( 4.6A)
GAI  A 501 ( 2.7A)
None
TRS  A 503 (-2.6A)
TRS  A 503 (-2.9A)
 0.57A 2v3dA-4lypA:
19.6		 2v3dA-4lypA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 8 HIS A 172
PHE A 169
PHE A 123
GLY A 114
 None
 0.97A 2vdbA-4lypA:
undetectable		 2vdbA-4lypA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_D_DVAD8_0
(GRAMICIDIN A)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.33A 2xdcC-4lypA:
undetectable
2xdcD-4lypA:
undetectable		 2xdcC-4lypA:
2.99
2xdcD-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_F_DVAF8_0
(GRAMICIDIN A)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.32A 2xdcE-4lypA:
undetectable
2xdcF-4lypA:
undetectable		 2xdcE-4lypA:
2.99
2xdcF-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 8 GLN A  28
ASP A 376
TYR A 364
SER A 386
 None
 1.04A 2xz5C-4lypA:
undetectable
2xz5D-4lypA:
undetectable		 2xz5C-4lypA:
15.14
2xz5D-4lypA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.32A 2y5mE-4lypA:
undetectable
2y5mF-4lypA:
undetectable		 2y5mE-4lypA:
2.99
2y5mF-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_D_DVAD8_0
(VAL-GRAMICIDIN A)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.30A 2y6nC-4lypA:
undetectable
2y6nD-4lypA:
undetectable		 2y6nC-4lypA:
2.99
2y6nD-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_F_DVAF8_0
(VAL-GRAMICIDIN A)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 TRP A 354
VAL A 387
TRP A  27
 TRS  A 503 (-2.9A)
None
None
 1.31A 2y6nE-4lypA:
undetectable
2y6nF-4lypA:
undetectable		 2y6nE-4lypA:
2.99
2y6nF-4lypA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 5 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.07A 3bcrA-4lypA:
2.8		 3bcrA-4lypA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.01A 3dd1A-4lypA:
undetectable		 3dd1A-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 0.99A 3dd1B-4lypA:
undetectable		 3dd1B-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.02A 3ddsA-4lypA:
undetectable		 3ddsA-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.00A 3ddsB-4lypA:
undetectable		 3ddsB-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 1.01A 3ddwA-4lypA:
undetectable		 3ddwA-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 6 ASN A 166
PHE A 169
ALA A 165
TYR A 126
 None
 0.99A 3ddwB-4lypA:
undetectable		 3ddwB-4lypA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_A_TESA501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 7 TYR A  87
HIS A 172
TYR A 188
TRP A 197
 None
 1.48A 3uzzA-4lypA:
10.1		 3uzzA-4lypA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 ASP A 329
ARG A 306
LYS A 328
 None
 1.21A 3wipG-4lypA:
undetectable		 3wipG-4lypA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 LYS A 220
LYS A 219
PRO A 223
 None
 1.22A 4dv1L-4lypA:
undetectable		 4dv1L-4lypA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		4 / 8 GLY A  11
TYR A 400
LEU A 404
VAL A 407
 GAI  A 502 (-3.2A)
None
None
None
 0.77A 4fgzB-4lypA:
undetectable		 4fgzB-4lypA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 CYH A 256
ASN A 260
LYS A 234
 None
TRS  A 503 ( 3.4A)
None
 1.48A 4k50A-4lypA:
undetectable		 4k50A-4lypA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 TYR A 156
THR A 253
PHE A 116
ALA A 152
ILE A 173
 None
 1.32A 5iwuA-4lypA:
undetectable		 5iwuA-4lypA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KLA_A_ACTA1505_0
(MATERNAL PROTEIN
PUMILIO)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		3 / 3 HIS A 225
LYS A 224
PHE A   2
 None
 1.03A 5klaA-4lypA:
undetectable		 5klaA-4lypA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_0
(CYTOCHROME P450 1A1)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 12 ILE A 218
SER A 228
ASN A 166
PHE A 123
ILE A 249
 None
 1.35A 6dwnB-4lypA:
undetectable		 6dwnB-4lypA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4lyp EXO-BETA-1,4-MANNOSI
DASE
(Rhizomucor
miehei) 		5 / 11 ILE A 173
ALA A 200
TYR A 126
GLY A 122
SER A 120
 None
 1.29A 6ieyA-4lypA:
undetectable
6ieyB-4lypA:
undetectable		 6ieyA-4lypA:
21.62
6ieyB-4lypA:
21.62