SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ILE A   8
PRO A  26
VAL A  73
PHE A  34
 None
 0.88A 2ygnA-4lzaA:
undetectable		 2ygnA-4lzaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ILE A 128
ARG A 157
ASP A 164
VAL A 135
 None
CL  A 201 ( 4.6A)
None
None
 1.17A 4nkxC-4lzaA:
undetectable		 4nkxC-4lzaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 5 ILE A 128
ARG A 157
ASP A 164
VAL A 135
 None
CL  A 201 ( 4.6A)
None
None
 1.19A 4nkxD-4lzaA:
undetectable		 4nkxD-4lzaA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OSR_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		4 / 7 VAL A 115
ILE A 117
VAL A  76
ALA A  54
 None
 0.56A 5osrA-4lzaA:
undetectable		 5osrA-4lzaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 GLY A 139
LEU A 138
VAL A  78
VAL A 115
ALA A  54
 None
 0.84A 6czmA-4lzaA:
undetectable
6czmC-4lzaA:
undetectable		 6czmA-4lzaA:
21.08
6czmC-4lzaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 PHE A 171
LEU A 151
THR A 152
SER A 167
ILE A 169
 None
None
None
CL  A 201 (-4.7A)
None
 1.21A 6ebpB-4lzaA:
undetectable		 6ebpB-4lzaA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 4lza ADENINE
PHOSPHORIBOSYLTRANSF
ERASE
(Thermoanaerobact
er
pseudethanolicus) 		5 / 10 PHE A 171
LEU A 151
THR A 152
SER A 167
ILE A 169
 None
None
None
CL  A 201 (-4.7A)
None
 1.22A 6ebpC-4lzaA:
undetectable		 6ebpC-4lzaA:
19.39