SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A 168
VAL A 170
TRP A 149
 None
 0.84A 1kqeA-4lzhA:
undetectable
1kqeE-4lzhA:
undetectable		 1kqeA-4lzhA:
7.87
1kqeE-4lzhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		3 / 3 ALA A 168
VAL A 170
TRP A 149
 None
 0.84A 1kqeB-4lzhA:
undetectable
1kqeD-4lzhA:
undetectable		 1kqeB-4lzhA:
7.87
1kqeD-4lzhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		3 / 3 TRP A 149
ALA A 168
VAL A 170
 None
 0.84A 1kqeB-4lzhA:
undetectable
1kqeD-4lzhA:
undetectable		 1kqeB-4lzhA:
7.87
1kqeD-4lzhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		3 / 3 TRP A 149
ALA A 168
VAL A 170
 None
 0.82A 1kqeA-4lzhA:
undetectable
1kqeE-4lzhA:
undetectable		 1kqeA-4lzhA:
7.87
1kqeE-4lzhA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		4 / 6 GLU A 249
ILE A 119
TYR A 111
GLY A  98
 None
 0.98A 1maaB-4lzhA:
undetectable
1maaD-4lzhA:
undetectable		 1maaB-4lzhA:
18.64
1maaD-4lzhA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 202
GLY A  61
MET A  65
LEU A  66
ILE A 125
 None
 1.37A 4p6xE-4lzhA:
undetectable		 4p6xE-4lzhA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 271
THR A 279
VAL A 278
VAL A 301
ARG A  33
 None
 1.32A 5v1tA-4lzhA:
undetectable		 5v1tA-4lzhA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 4lzh L,D-TRANSPEPTIDASE
(Klebsiella
pneumoniae) 		4 / 6 VAL A 236
ASN A 252
PRO A 253
GLU A  67
 None
 1.22A 6h7uA-4lzhA:
undetectable		 6h7uA-4lzhA:
20.95