SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4lzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 VAL A  50
TRP A 174
TRP A  76
 None
 1.31A 1c4dA-4lziA:
undetectable
1c4dB-4lziA:
undetectable		 1c4dA-4lziA:
4.69
1c4dB-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E6W_C_ESTC302_1
(SHORT CHAIN
3-HYDROXYACYL-COA
DEHYDROGENASE)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 4 ALA A 211
GLN A 208
TYR A 228
LEU A 232
 None
 1.49A 1e6wC-4lziA:
undetectable		 1e6wC-4lziA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		5 / 10 ALA A 156
LEU A 154
LEU A 138
ILE A 258
LEU A 185
 None
 1.19A 1pcgA-4lziA:
undetectable		 1pcgA-4lziA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_A_ESTA1_1
(ESTROGEN RECEPTOR)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		5 / 10 ALA A 250
LEU A 248
LEU A 232
ILE A 164
LEU A 279
 None
 1.30A 1pcgA-4lziA:
undetectable		 1pcgA-4lziA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 VAL A  51
VAL A  77
TRP A 174
 None
 0.98A 1w5uA-4lziA:
undetectable
1w5uB-4lziA:
undetectable		 1w5uA-4lziA:
4.69
1w5uB-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 5 ALA A 167
TYR A 165
ALA A 120
TYR A 124
 None
 1.09A 1xl6A-4lziA:
undetectable
1xl6B-4lziA:
undetectable		 1xl6A-4lziA:
20.18
1xl6B-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 5 ALA A 261
TYR A 259
ALA A 214
TYR A 218
 None
 0.96A 1xl6A-4lziA:
undetectable
1xl6B-4lziA:
undetectable		 1xl6A-4lziA:
20.18
1xl6B-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 VAL A  77
TRP A 174
VAL A  51
 None
 1.00A 2izqC-4lziA:
undetectable
2izqD-4lziA:
undetectable		 2izqC-4lziA:
4.69
2izqD-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 4 ALA A 120
TYR A 124
ALA A 167
TYR A 165
 None
 1.24A 2wlkA-4lziA:
undetectable
2wlkB-4lziA:
undetectable		 2wlkA-4lziA:
20.18
2wlkB-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 4 ALA A 167
TYR A 165
ALA A 120
TYR A 124
 None
 1.06A 2wlkA-4lziA:
undetectable
2wlkB-4lziA:
undetectable		 2wlkA-4lziA:
20.18
2wlkB-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 4 ALA A 214
TYR A 218
ALA A 261
TYR A 259
 None
 1.25A 2wlkA-4lziA:
undetectable
2wlkB-4lziA:
undetectable		 2wlkA-4lziA:
20.18
2wlkB-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		4 / 4 ALA A 261
TYR A 259
ALA A 214
TYR A 218
 None
 0.93A 2wlkA-4lziA:
undetectable
2wlkB-4lziA:
undetectable		 2wlkA-4lziA:
20.18
2wlkB-4lziA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 TRP A 174
VAL A  50
TRP A  76
 None
 1.31A 3zq8A-4lziA:
undetectable
3zq8B-4lziA:
undetectable		 3zq8A-4lziA:
4.69
3zq8B-4lziA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 ASP A  21
LEU A  22
PHE A  25
 None
 0.66A 4pthA-4lziA:
undetectable		 4pthA-4lziA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		3 / 3 GLU A 267
TYR A 244
GLU A 206
 None
 0.72A 4ryaA-4lziA:
undetectable		 4ryaA-4lziA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		5 / 12 LYS A 161
GLY A 160
GLU A 133
ASN A 125
ALA A 130
 None
 1.18A 5arfA-4lziA:
undetectable		 5arfA-4lziA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ARF_A_SAMA1002_0
(N-LYSINE
METHYLTRANSFERASE
SMYD2)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		5 / 12 LYS A 161
GLY A 160
GLU A 133
ASN A 125
TYR A 165
 None
 1.39A 5arfA-4lziA:
undetectable		 5arfA-4lziA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 4lzi MULTICYSTATIN
(Solanum
tuberosum) 		5 / 11 ALA A 156
LEU A 154
LEU A 138
ILE A 258
LEU A 185
 None
 1.22A 5dxbB-4lziA:
undetectable		 5dxbB-4lziA:
18.47