SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m01'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 TYR A 446
ASN A 480
HIS A 325
TYR A 322
 None
 1.18A 1mxgA-4m01A:
undetectable		 1mxgA-4m01A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.29A 1p6kB-4m01A:
undetectable		 1p6kB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.21A 1rs6B-4m01A:
undetectable		 1rs6B-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.36A 1zzqA-4m01A:
undetectable		 1zzqA-4m01A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.23A 1zzqB-4m01A:
undetectable		 1zzqB-4m01A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.29A 1zzuB-4m01A:
undetectable		 1zzuB-4m01A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 328
GLY A 329
ASN A 480
ALA A 473
GLY A 319
 None
 1.05A 2pkkA-4m01A:
undetectable		 2pkkA-4m01A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		3 / 3 SER A 309
TYR A 435
HIS A 311
 None
 0.49A 2r2vD-4m01A:
undetectable		 2r2vD-4m01A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELU_A_SAMA4633_0
(METHYLTRANSFERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.98A 3eluA-4m01A:
undetectable		 3eluA-4m01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EMB_A_SAMA4633_0
(METHYLTRANSFERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.99A 3embA-4m01A:
undetectable		 3embA-4m01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.99A 3gczA-4m01A:
undetectable		 3gczA-4m01A:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.32A 3n62B-4m01A:
undetectable		 3n62B-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.28A 3n66B-4m01A:
undetectable		 3n66B-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 6 THR A 479
ASN A 480
GLY A 331
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.16A 3w9tE-4m01A:
undetectable		 3w9tE-4m01A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 ASN A 374
ALA A 376
SER A 375
VAL A 403
 None
 1.07A 4ijiH-4m01A:
undetectable		 4ijiH-4m01A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.25A 4kcnB-4m01A:
undetectable		 4kcnB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 GLN A 289
THR A 288
THR A 475
THR A 424
 None
 1.06A 4mbsA-4m01A:
undetectable		 4mbsA-4m01A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.25A 4oltB-4m01A:
undetectable		 4oltB-4m01A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.26A 4qwpB-4m01A:
undetectable		 4qwpB-4m01A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 479
GLY A 329
HIS A 325
ASP A 290
 None
 1.17A 5c0oH-4m01A:
undetectable		 5c0oH-4m01A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_A_SAMA4001_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.99A 5ehiA-4m01A:
undetectable		 5ehiA-4m01A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.98A 5ehiC-4m01A:
undetectable		 5ehiC-4m01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 1.00A 5eiwA-4m01A:
undetectable		 5eiwA-4m01A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_A_SAMA301_0
(NS5
METHYLTRANSFERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.98A 5ekxA-4m01A:
undetectable		 5ekxA-4m01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 None
 0.94A 5i71A-4m01A:
undetectable		 5i71A-4m01A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 ALA A 349
PHE A 362
GLY A 361
GLY A 354
GLY A 393
 None
 0.98A 5i73A-4m01A:
undetectable		 5i73A-4m01A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		3 / 3 SER A 549
ALA A 548
THR A 497
 None
 0.74A 5n0xB-4m01A:
undetectable		 5n0xB-4m01A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_C_SAMC301_0
(NS5)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 GLY A 331
GLY A 329
GLY A 476
THR A 366
ILE A 332
 None
None
GOL  A 602 (-2.8A)
None
None
 0.93A 5njvC-4m01A:
undetectable		 5njvC-4m01A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 6 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.50A 5ov9A-4m01A:
undetectable		 5ov9A-4m01A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.45A 5ov9B-4m01A:
undetectable		 5ov9B-4m01A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.26A 5vunA-4m01A:
undetectable		 5vunA-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.19A 5vunB-4m01A:
undetectable		 5vunB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.20A 5vuoB-4m01A:
undetectable		 5vuoB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 8 ASN A 275
GLN A 482
ASN A 347
ASP A 330
 None
None
None
GOL  A 602 (-3.3A)
 1.17A 6auuB-4m01A:
undetectable		 6auuB-4m01A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)		 4m01 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		3 / 3 TYR A 446
ALA A 391
LEU A 318
 None
 0.67A 6d9kF-4m01A:
undetectable		 6d9kF-4m01A:
18.34