SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		3 / 3 ASN A 519
ALA A 495
ASN A 562
 None
 0.76A 1n4fA-4m02A:
undetectable		 1n4fA-4m02A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 701 ( 4.5A)
None
CA  A 701 (-2.2A)
CA  A 701 (-3.0A)
 1.05A 2g70A-4m02A:
undetectable		 2g70A-4m02A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 GLY A 603
THR A 604
ASP A 601
ASN A 602
 CA  A 701 ( 4.5A)
None
CA  A 701 (-2.2A)
CA  A 701 (-3.0A)
 1.07A 2g70B-4m02A:
undetectable		 2g70B-4m02A:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 SER A 619
ILE A 586
GLY A 617
PRO A 615
 None
 1.05A 3uboB-4m02A:
undetectable		 3uboB-4m02A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		5 / 12 ALA A 548
THR A 550
GLY A 518
ALA A 563
THR A 561
 None
 0.97A 4enhA-4m02A:
undetectable		 4enhA-4m02A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA302_1
(CHITOSANASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.32A 4oltA-4m02A:
undetectable		 4oltA-4m02A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB302_1
(CHITOSANASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.31A 4oltB-4m02A:
undetectable		 4oltB-4m02A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA302_1
(CHITOSANASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.31A 4qwpA-4m02A:
undetectable		 4qwpA-4m02A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB306_1
(CHITOSANASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 5 THR A 505
THR A 506
ASP A 503
TYR A 538
 None
 1.32A 4qwpB-4m02A:
undetectable		 4qwpB-4m02A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		3 / 3 SER A 549
ALA A 548
THR A 497
 None
 0.73A 5n0xB-4m02A:
undetectable		 5n0xB-4m02A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA609_0
(ACETYLCHOLINESTERASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 6 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.46A 5ov9A-4m02A:
undetectable		 5ov9A-4m02A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 4m02 SERINE-RICH ADHESIN
FOR PLATELETS
(Staphylococcus
aureus) 		4 / 7 TYR A 569
TYR A 501
ASP A 544
TYR A 516
 None
 1.40A 5ov9B-4m02A:
undetectable		 5ov9B-4m02A:
16.83