SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		3 / 3 ASP A 139
PHE A  65
VAL A 101
 None
 0.62A 1kijB-4m0dA:
undetectable		 1kijB-4m0dA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 11 ALA A 182
ASP A 183
ILE A 186
ILE A  74
ALA A 171
 None
 1.04A 2b60B-4m0dA:
undetectable		 2b60B-4m0dA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ILE A  24
GLY A 197
THR A 196
THR A  78
LEU A  82
 None
 1.06A 2y7hB-4m0dA:
undetectable		 2y7hB-4m0dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ILE A  24
GLY A 197
THR A 196
THR A  78
LEU A  82
 None
 1.06A 2y7hC-4m0dA:
undetectable		 2y7hC-4m0dA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		3 / 3 GLY A  69
ASP A 139
SER A 136
 None
 0.67A 3brfA-4m0dA:
undetectable		 3brfA-4m0dA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 203
THR A 205
ILE A  47
ALA A  46
ILE A 189
 None
 1.06A 3ddyA-4m0dA:
undetectable		 3ddyA-4m0dA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		4 / 4 PRO A 151
THR A 150
GLY A 197
THR A 196
 None
 1.12A 3ib1A-4m0dA:
undetectable		 3ib1A-4m0dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		4 / 8 ASP A 183
GLY A 143
SER A 169
ILE A 168
 None
 0.75A 3ihzB-4m0dA:
undetectable		 3ihzB-4m0dA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.15A 3k2hA-4m0dA:
undetectable		 3k2hA-4m0dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.15A 3k2hB-4m0dA:
undetectable		 3k2hB-4m0dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.21A 3nrrA-4m0dA:
undetectable		 3nrrA-4m0dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B530_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.22A 3nrrB-4m0dA:
undetectable		 3nrrB-4m0dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 LEU A 290
ILE A 274
ALA A 273
ALA A 235
GLY A  95
 None
 1.08A 3nxuA-4m0dA:
undetectable		 3nxuA-4m0dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ALA A 182
GLY A 143
ILE A  74
ARG A  70
VAL A 140
 None
 1.11A 3o7wA-4m0dA:
3.4		 3o7wA-4m0dA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 VAL A  84
LEU A 211
ILE A  72
VAL A 142
LEU A 141
 None
 1.20A 3w68A-4m0dA:
undetectable		 3w68A-4m0dA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		4 / 6 THR A 123
ASN A 122
GLY A 118
ASP A 121
 None
 1.29A 3w9tE-4m0dA:
undetectable		 3w9tE-4m0dA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		4 / 7 GLY A 103
ILE A  74
GLY A  75
ILE A 144
 None
 0.64A 4eatA-4m0dA:
undetectable		 4eatA-4m0dA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 11 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.22A 4fogA-4m0dA:
undetectable		 4fogA-4m0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 11 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.16A 4fogC-4m0dA:
undetectable		 4fogC-4m0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.18A 4foxB-4m0dA:
undetectable		 4foxB-4m0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.21A 4foxE-4m0dA:
undetectable		 4foxE-4m0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 11 SER A 218
ILE A  61
ASP A 139
GLY A  69
PHE A  65
 None
 1.22A 4foxH-4m0dA:
undetectable		 4foxH-4m0dA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 LEU A 214
VAL A 210
ILE A 170
ILE A 168
ALA A 182
 None
 0.98A 4ltwA-4m0dA:
undetectable		 4ltwA-4m0dA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 LEU A 141
ILE A  74
ILE A 144
GLY A 103
ILE A  61
 None
 1.02A 4nkxA-4m0dA:
undetectable		 4nkxA-4m0dA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ILE A  61
ASN A 138
ARG A  70
VAL A 140
ILE A 168
 None
 1.15A 4rvgA-4m0dA:
2.7		 4rvgA-4m0dA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1F_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ASP A 129
LEU A 130
SER A 132
LEU A 141
ILE A  74
 None
 0.70A 4x1fA-4m0dA:
undetectable		 4x1fA-4m0dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1G_A_3WFA501_1
(NUCLEAR RECEPTOR
SUBFAMILY 1 GROUP I
MEMBER 2)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 12 ASP A 129
LEU A 130
SER A 132
LEU A 141
ILE A  74
 None
 0.70A 4x1gA-4m0dA:
undetectable		 4x1gA-4m0dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQF_A_LCRA612_1
(SERUM ALBUMIN)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		5 / 9 LEU A 272
LEU A 289
LEU A 290
LEU A 297
ALA A 300
 None
 1.03A 5dqfA-4m0dA:
undetectable		 5dqfA-4m0dA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		3 / 3 ALA A 259
GLN A 250
THR A 252
 None
 0.75A 5n0oA-4m0dA:
undetectable		 5n0oA-4m0dA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_1
(HIV-1 PROTEASE)		 4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE
(Haemophilus
influenzae) 		6 / 12 GLY A 107
ALA A 106
ASP A 129
VAL A 153
ILE A  74
GLY A  80
 None
 1.38A 6dj2B-4m0dA:
undetectable		 6dj2B-4m0dA:
19.70