SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		4 / 4 ILE A 287
LEU A 265
VAL A 311
ILE A 315
 None
 0.92A 1fm6D-4m0hA:
undetectable		 1fm6D-4m0hA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		5 / 9 ARG A 281
LEU A 312
ILE A 276
GLY A 264
LEU A 265
 None
 1.27A 2v0mB-4m0hA:
undetectable		 2v0mB-4m0hA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		4 / 7 LEU A 289
ILE A 272
ALA A 213
ILE A 239
 None
 0.85A 2xkwA-4m0hA:
undetectable		 2xkwA-4m0hA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		3 / 3 PHE A 175
TYR A 156
LEU A 197
 None
 0.73A 3keeB-4m0hA:
undetectable		 3keeB-4m0hA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		3 / 3 PHE A 175
TYR A 156
LEU A 197
 None
 0.65A 3sueB-4m0hA:
undetectable		 3sueB-4m0hA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3A_A_TACA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		5 / 12 LEU A 261
HIS A 147
PHE A 174
GLN A 262
SER A 200
 None
 1.29A 4b3aA-4m0hA:
undetectable		 4b3aA-4m0hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		4 / 7 ARG A 281
GLY A 171
ASN A 202
GLU A 172
 None
 0.99A 4g0vA-4m0hA:
undetectable		 4g0vA-4m0hA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		4 / 5 ASP A 278
TRP A 260
VAL A 257
ALA A 259
 None
 1.17A 5dl9A-4m0hA:
undetectable		 5dl9A-4m0hA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNX_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		5 / 12 VAL A 203
PHE A 185
LEU A 140
THR A 139
ARG A 217
 None
 1.40A 5hnxB-4m0hA:
undetectable		 5hnxB-4m0hA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 4m0h CONSERVED
HYPOTHETICAL
PROTEIN, PUTATIVE
ANTI-SIGMA FACTOR
(Parabacteroides
distasonis) 		5 / 11 GLY A 171
GLY A 151
LEU A 148
VAL A 130
MET A 169
 None
 1.27A 6i5zD-4m0hA:
undetectable		 6i5zD-4m0hA:
20.96