SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
4 / 5 GLU A  44
LEU A  38
LEU A  41
LEU A  39
None
1.08A 1np1A-4m0kA:
undetectable
1np1A-4m0kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 11 ALA A  45
LEU A  47
LEU A 153
ALA A 151
LEU A  68
None
1.28A 1tz8A-4m0kA:
undetectable
1tz8B-4m0kA:
undetectable
1tz8A-4m0kA:
18.81
1tz8B-4m0kA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 9 LEU A 177
GLU A   7
ALA A  12
GLU A  37
LEU A  41
None
1.42A 2azqA-4m0kA:
undetectable
2azqA-4m0kA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
4 / 6 ALA A 135
ILE A  61
VAL A  83
GLU A  62
None
None
None
AMP  A 300 (-4.0A)
0.94A 2cizA-4m0kA:
undetectable
2cizA-4m0kA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 10 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.40A 2cp4A-4m0kA:
undetectable
2cp4A-4m0kA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
4 / 8 GLY A 161
GLY A 131
THR A 132
ALA A 133
None
AMP  A 300 (-3.8A)
AMP  A 300 (-3.6A)
None
0.59A 2ej3A-4m0kA:
undetectable
2ej3A-4m0kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 11 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.28A 3lxiB-4m0kA:
undetectable
3lxiB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 10 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.28A 4c9nB-4m0kA:
undetectable
4c9nB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 10 THR A 173
LEU A 165
GLY A 161
VAL A 126
ASP A 124
None
None
None
AMP  A 300 (-3.9A)
AMP  A 300 (-3.0A)
1.27A 4c9pB-4m0kA:
undetectable
4c9pB-4m0kA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA409_0
(FAD:PROTEIN FMN
TRANSFERASE)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
5 / 5 ILE A 114
VAL A 120
ILE A 122
VAL A 140
THR A 136
None
1.05A 4xdtA-4m0kA:
undetectable
4xdtA-4m0kA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECM_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
4 / 5 THR A 136
ALA A 133
THR A 132
TYR A  98
None
None
AMP  A 300 (-3.6A)
None
1.36A 5ecmA-4m0kA:
4.0
5ecmA-4m0kA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA605_0
(SERUM ALBUMIN)
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus)
4 / 8 HIS A 172
LEU A  68
GLY A  69
LEU A  72
None
0.56A 6mdqA-4m0kA:
undetectable
6mdqA-4m0kA:
17.82