SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 PHE A 646
LEU A 664
PHE A 117
TRP A 647
LEU A 661
 None
 1.42A 1a8uA-4m0mA:
9.5		 1a8uA-4m0mA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 PHE A 646
LEU A 664
PHE A 117
TRP A 647
LEU A 661
 None
 1.40A 1a8uB-4m0mA:
9.5		 1a8uB-4m0mA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 VAL A 571
ASN A 575
ALA A 578
LEU A 524
ALA A 522
 None
 0.87A 1fk6A-4m0mA:
undetectable		 1fk6A-4m0mA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 VAL A 571
LEU A 574
ASN A 575
LEU A 524
ALA A 522
 None
 0.83A 1fk6A-4m0mA:
undetectable		 1fk6A-4m0mA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 624
LEU A 464
VAL A 467
MET A 486
LEU A 482
 PG4  A 803 (-4.1A)
None
None
None
None
 1.05A 1gseB-4m0mA:
undetectable		 1gseB-4m0mA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_ACTA148_0
(UPF0066 PROTEIN
AF_0241)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 VAL A 734
GLU A 730
GLU A 731
 None
 0.80A 2nv4A-4m0mA:
undetectable		 2nv4A-4m0mA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 345
GLU A 346
GLN A 334
 None
 0.95A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 565
GLU A 566
GLN A 561
 None
 1.03A 2p16A-4m0mA:
undetectable		 2p16A-4m0mA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 ILE A 100
THR A 104
MET A 153
LEU A 160
 None
 0.89A 2xrhA-4m0mA:
undetectable		 2xrhA-4m0mA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 4 GLY A 178
ASP A 182
GLY A 109
THR A  23
 None
 1.04A 3k4vC-4m0mA:
undetectable		 3k4vC-4m0mA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 VAL A 373
LEU A 380
SER A 381
ALA A 394
LEU A 408
 None
 0.85A 3n8yB-4m0mA:
undetectable		 3n8yB-4m0mA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 LYS A 307
GLU A 310
TRP A 311
 None
 1.30A 3v4tH-4m0mA:
undetectable		 3v4tH-4m0mA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 LEU A 199
TYR A 231
LYS A 229
GLU A 196
 None
 1.21A 4f3tA-4m0mA:
3.1		 4f3tA-4m0mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 438
LEU A 463
LEU A 462
ILE A 509
THR A 455
 None
 1.22A 4f4dA-4m0mA:
2.6		 4f4dA-4m0mA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 SER A 197
TYR A 216
MET A 151
ASP A 148
 None
 0.86A 4hxyB-4m0mA:
undetectable		 4hxyB-4m0mA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_J_SASJ804_1
(SEPIAPTERIN
REDUCTASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 LEU A 380
LEU A 303
CYH A 304
TYR A 386
ASP A 335
 None
 1.28A 4j7xJ-4m0mA:
5.3		 4j7xJ-4m0mA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYS_B_VIBB501_1
(THIAMINE
PYRIDINYLASE I)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 TYR A 332
ASP A 331
ILE A 325
SER A 324
THR A 439
 None
None
None
PO4  A 804 (-2.9A)
None
 1.44A 4kysB-4m0mA:
undetectable		 4kysB-4m0mA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 LYS A 563
TYR A 564
GLU A 566
TYR A 516
 None
 1.10A 4lb2A-4m0mA:
undetectable		 4lb2A-4m0mA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 5 LEU A 438
SER A 440
LEU A 464
LEU A 482
 None
 1.31A 4n09D-4m0mA:
4.9		 4n09D-4m0mA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 LEU A 434
ASP A 429
ILE A 441
PRO A 425
 None
 0.99A 4xi3C-4m0mA:
undetectable		 4xi3C-4m0mA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 6 LEU A 199
TYR A 231
LYS A 229
GLU A 196
 None
 1.20A 4z4gA-4m0mA:
3.0		 4z4gA-4m0mA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_B_DESB600_1
(ESTROGEN RECEPTOR)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 11 LEU A 116
ALA A 119
LEU A 140
LEU A  18
LEU A 157
 None
 1.33A 4zn7B-4m0mA:
2.7		 4zn7B-4m0mA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MQT_C_STIC302_1
(DEOXYCYTIDINE KINASE)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 12 GLU A 343
MET A 200
GLU A 234
ARG A 299
GLU A 196
 None
None
PO4  A 805 ( 4.4A)
None
None
 1.46A 5mqtC-4m0mA:
2.1		 5mqtC-4m0mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE A  96
ILE A 100
LEU A 103
ILE A 659
ASN A 655
 None
 1.35A 5vkqA-4m0mA:
4.3
5vkqD-4m0mA:
4.3		 5vkqA-4m0mA:
18.36
5vkqD-4m0mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE A 659
ASN A 655
ILE A  96
ILE A 100
LEU A 103
 None
 1.34A 5vkqA-4m0mA:
4.3
5vkqB-4m0mA:
4.4		 5vkqA-4m0mA:
18.36
5vkqB-4m0mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		5 / 10 ILE A 659
ASN A 655
ILE A  96
ILE A 100
LEU A 103
 None
 1.35A 5vkqC-4m0mA:
4.3
5vkqD-4m0mA:
4.3		 5vkqC-4m0mA:
18.36
5vkqD-4m0mA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		3 / 3 SER A 324
HIS A 212
TYR A 447
 PO4  A 804 (-2.9A)
PO4  A 804 (-3.8A)
None
 0.94A 5y2tA-4m0mA:
undetectable		 5y2tA-4m0mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN
(Legionella
pneumophila) 		4 / 7 ASP A 638
GLU A 678
ASP A 674
GLU A 667
 None
 1.27A 6mn5B-4m0mA:
undetectable		 6mn5B-4m0mA:
6.83