SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4m0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 7 PHE A  92
ALA A 113
PHE A 138
PHE A 137
 None
 1.24A 1lqtA-4m0pA:
undetectable		 1lqtA-4m0pA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 7 PHE A  92
ALA A 113
PHE A 138
PHE A 137
 None
 1.24A 1lquA-4m0pA:
undetectable		 1lquA-4m0pA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 6 ILE A 140
PRO A  93
LEU A  70
ILE A  89
 None
 1.00A 2q83B-4m0pA:
undetectable		 2q83B-4m0pA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 8 ALA A 182
ASP A 188
ILE A 247
PRO A 170
 None
 0.75A 3nu9A-4m0pA:
undetectable		 3nu9A-4m0pA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 4 PRO A  90
LEU A  15
ILE A  19
ARG A  22
 None
 1.39A 3w1wA-4m0pA:
3.7		 3w1wA-4m0pA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 5 VAL A 309
LEU A 312
SER A 310
MET A 127
 SO4  A1001 (-3.9A)
None
SO4  A1001 (-2.8A)
None
 1.26A 4e1gA-4m0pA:
undetectable		 4e1gA-4m0pA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 5 VAL A 168
LEU A 236
ILE A 192
LEU A 191
 None
 0.78A 4mghA-4m0pA:
2.6		 4mghA-4m0pA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		6 / 11 LEU A  71
GLY A 120
ALA A 121
ASP A 122
ILE A  55
ILE A  79
 None
 1.41A 4q1xA-4m0pA:
undetectable		 4q1xA-4m0pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		6 / 10 LEU A  71
GLY A 120
ALA A 121
ASP A 122
ILE A  55
ILE A  79
 None
 1.40A 4q1yA-4m0pA:
undetectable		 4q1yA-4m0pA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		4 / 5 ALA A 121
ALA A  87
ILE A  74
LEU A  71
 None
 0.60A 5jncD-4m0pA:
undetectable		 5jncD-4m0pA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AJI_A_AY6A1001_0
(DRUG EXPORTERS OF
THE RND
SUPERFAMILY-LIKE
PROTEIN,ENDOLYSIN)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		5 / 12 LEU A 218
ILE A 247
VAL A 178
VAL A 244
ALA A 216
 None
 1.20A 6ajiA-4m0pA:
undetectable		 6ajiA-4m0pA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1
(Homo
sapiens) 		5 / 11 ALA A 241
LEU A 237
VAL A 244
PHE A 266
ILE A 229
 None
 1.22A 6h1lB-4m0pA:
undetectable		 6h1lB-4m0pA:
24.10